Abstract:
:The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models have also lent mechanistic insights into the biochemical and molecular pathways by which adequate folate exposure conveys these protective effects, and human studies are beginning to confirm the relevance of this mechanistic understanding to human cancer biology. Enhancement of genetic stability appears to be a major mechanism by which folate sufficiency protects against carcinogenesis. To date, the Wnt signaling cascade has been the pathway most examined in this regard. The relationship between folate exposure and colorectal cancer risk is a complex one, in part because a number of extrinsic and intrinsic factors act as effect modifiers. This review discusses how the intake of the other three B-vitamins integral to the 1-carbon pathway acts as one such effect modifier. In addition, two concepts that remain matters of considerable debate are whether parental intake of folate impacts on subsequent cancer risk in the offspring, and whether excessive intakes of folate may have a paradoxical cancer-promoting effect: observations underlying these two concepts are presented as well.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Mason JB,Tang SYdoi
10.1016/j.mam.2016.11.010subject
Has Abstractpub_date
2017-02-01 00:00:00pages
73-79eissn
0098-2997issn
1872-9452pii
S0098-2997(16)30095-4journal_volume
53pub_type
杂志文章,评审abstract::The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.05.002
更新日期:2019-10-01 00:00:00
abstract::When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane st...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.08.004
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abstract::17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.07.001
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.07.001
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abstract::Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/s0098-2997(97)00011-3
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abstract::Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated by two main mechanisms: by adjusting the rates of synthesis and of export from cells. Some of the proteins responsible for GSH exp...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2008.08.004
更新日期:2009-02-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2010.09.006
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.12.008
更新日期:2007-02-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2007.01.003
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2015.01.004
更新日期:2015-04-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.07.002
更新日期:2018-10-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.03.008
更新日期:2012-10-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.02.003
更新日期:2017-12-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/0098-2997(94)90039-6
更新日期:1994-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(00)00005-4
更新日期:2000-08-01 00:00:00
abstract::In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(03)00017-7
更新日期:2003-08-01 00:00:00
abstract::Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.06.005
更新日期:2019-10-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.013
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abstract::RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.12.004
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abstract::Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.03.005
更新日期:2012-08-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2004.02.012
更新日期:2004-02-01 00:00:00
abstract::This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2. SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance a...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2013.01.002
更新日期:2013-04-01 00:00:00
abstract::Carnosine and related dipeptides such as anserine are naturally-occurring histidine-containing compounds. They are found in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. The biological role of these dipeptides are conjectur...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/0098-2997(92)90006-l
更新日期:1992-01-01 00:00:00
abstract::Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.08.001
更新日期:2013-07-01 00:00:00
abstract::Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.08.002
更新日期:2018-12-01 00:00:00
abstract::Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.02.002
更新日期:2016-08-01 00:00:00
abstract::Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(03)00035-9
更新日期:2003-12-01 00:00:00
abstract::Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.11.005
更新日期:2018-04-01 00:00:00