Abstract:
:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat or oxidative stress acquire capacity to exclude intracellular 4-HNE at a faster rate by inducing hGST5.8 which conjugate 4-HNE to GSH, and RLIP76 which mediates the ATP-dependent transport of the GSH-conjugate of 4-HNE. The cells preconditioned with mild transient stress acquire resistance to H(2)O(2) and 4-HNE induced apoptosis by excluding intracellular 4-HNE at an accelerated pace. Furthermore, a decrease in intracellular concentration of 4-HNE achieved by transfecting cells with mGSTA4-4 or hGSTA4-4 results in a faster growth rate. These studies strongly suggest a role of 4-HNE in stress mediated signaling.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Awasthi YC,Sharma R,Cheng JZ,Yang Y,Sharma A,Singhal SS,Awasthi Sdoi
10.1016/s0098-2997(03)00017-7keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
219-30issue
4-5eissn
0098-2997issn
1872-9452pii
S0098299703000177journal_volume
24pub_type
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