Abstract：
:17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about how hormone binding influences ER conformation(s) and how this conformation(s), in turn, influences the interaction of ERs with co-activators or co-repressors and hence determines ER binding to DNA and cellular outcomes. This information has helped to shed light on the connection between E2 and the development or progression of numerous diseases. Current therapeutic strategy in the treatment of E2-related pathologies relies on the modulation of ER trancriptional activity by anti-estrogens; however, data accumulated during the last five years reveal that ER activities are not only restricted to the nucleus. ERs are very mobile proteins continuously shuttling between protein targets located within various cellular compartments (e.g., membrane, nucleus). This allows E2 to generate different and synergic signal transduction pathways (i.e., non-genomic and genomic) which provide plasticity for cell response to E2. Understanding the structural basis and the molecular mechanisms by which ER transduce E2 signals in target cells will allow to create new pharmacologic therapies aimed at the treatment of a variety of human diseases affecting the cardiovascular system, the reproductive system, the skeletal system, the nervous system, the mammary gland, and many others.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Ascenzi P,Bocedi A,Marino Mdoi
10.1016/j.mam.2006.07.001subject
Has Abstractpub_date
2006-08-01 00:00:00pages
299-402issue
4eissn
0098-2997issn
1872-9452pii
S0098-2997(06)00015-Xjournal_volume
27pub_type
杂志文章,评审abstract：:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(97)00016-2
更新日期：1997-01-01 00:00:00
abstract：:The aldehyde 4-hydroxynonenal (HNE) is a major end-product of peroxidation of membrane n-6-polyunsaturated fatty acids. Primary reactants for HNE are the amino acids cysteine, histidine and lysine, and quantitatively, proteins and peptides represent the most important group of HNE-targeted biomolecules. HNE-protein ad...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2007.09.016
更新日期：2008-02-01 00:00:00
abstract：:Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/j.mam.2020.100923
更新日期：2020-11-04 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.02.002
更新日期：2016-08-01 00:00:00
abstract：:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avast...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.02.005
更新日期：2010-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.004
更新日期：2007-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2015.01.004
更新日期：2015-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2011.04.001
更新日期：2011-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.08.002
更新日期：2018-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.012
更新日期：2013-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.09.006
更新日期：2018-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(00)00005-4
更新日期：2000-08-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2004.02.012
更新日期：2004-02-01 00:00:00
abstract：:Reactive oxygen species (ROS) have been frequently implicated in the initiation and promotion phases of carcinogenesis. Antioxidant enzymes, which can antagonize this process, are lowered in a number of malignancies. The enzyme most commonly decreased is the mitochondrial Mn-containing superoxide dismutase (MnSOD) enc...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(93)90012-3
更新日期：1993-01-01 00:00:00
abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90039-6
更新日期：1994-01-01 00:00:00
abstract：:Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.11.005
更新日期：2018-04-01 00:00:00
abstract：:Metastasis is a complex non-stochastic process that is most likely the result of genetic and epigenetic interactions of a wide variety of genes. The search for a single gene which can encompass such a pleiotropic response as to account for the observed phenotypic characteristics of metastatic tumour populations has be...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/0098-2997(90)90005-m
更新日期：1990-01-01 00:00:00
abstract：:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...
journal_title：Molecular aspects of medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0098-2997(94)90028-0
更新日期：1994-01-01 00:00:00
abstract：:Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.11.002
更新日期：2017-06-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.10.001
更新日期：2017-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(97)00031-9
更新日期：1997-01-01 00:00:00
abstract：:Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.013
更新日期：2013-04-01 00:00:00
abstract：:Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2011.10.003
更新日期：2012-02-01 00:00:00
abstract：:ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.03.003
更新日期：2018-12-01 00:00:00
abstract：:The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.10.005
更新日期：2013-02-01 00:00:00
abstract：:The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.07.001
更新日期：2010-10-01 00:00:00
abstract：:For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.07.001
更新日期：2019-08-01 00:00:00
abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.09.006
更新日期：2010-12-01 00:00:00
abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90018-3
更新日期：1994-01-01 00:00:00
abstract：:The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.11.010
更新日期：2017-02-01 00:00:00
