Abstract:
:Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critical for myofiber formation in early life stages and for sustaining repair in response to muscle damage or trauma. Here we will review the most recent findings on the causes underlying satellite cell functional decline with aging, and will discuss the prevalent view whereby age-associated extrinsic factor alterations impact negatively on satellite cell-intrinsic mechanisms, resulting in deficient muscle regeneration with aging. Further understanding of the interplay between satellite cell extrinsic and intrinsic factors in sarcopenia will facilitate therapies aimed at improving muscle repair in the increasing aging population.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Sousa-Victor P,Muñoz-Cánoves Pdoi
10.1016/j.mam.2016.02.002subject
Has Abstractpub_date
2016-08-01 00:00:00pages
109-17eissn
0098-2997issn
1872-9452pii
S0098-2997(16)30006-1journal_volume
50pub_type
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