Abstract：
:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in excess of $340 billion US (American-Health-Assistance-Foundation, 2012). The majority of AMD patients in the United States are not eligible for clinical treatments (Biarnes et al., 2011; Klein et al., 2011). Preventive interventions through dietary modulation are attractive strategies because many studies suggest a benefit of micro- and macronutrients with respect to AMD, as well as other age-related debilities, and with few, if any, adverse effects (Chiu, 2011). Preservation of vision would enhance quality of life for millions of elderly people, and alleviate the personal and public health financial burden of AMD (Frick et al., 2007; Wood et al., 2011). Observational studies indicate that maintaining adequate levels of omega-3 fatty acids (i.e. with 2 servings/week of fish) or a low glycemic index diet may be particularly beneficial for early AMD and that higher levels of carotenoids may be protective, most probably, against neovascular AMD. Intervention trials are needed to better understand the full effect of these nutrients and/or combinations of nutrients on retinal health. Analyses that describe effects of a nutrient on onset and/or progress of AMD are valuable because they indicate the value of a nutrient to arrest AMD at the early stages. This comprehensive summary provides essential information about the value of nutrients with regard to diminishing risk for onset or progress of AMD and can serve as a guide until data from ongoing intervention trials are available.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Weikel KA,Chiu CJ,Taylor Adoi
10.1016/j.mam.2012.03.005subject
Has Abstractpub_date
2012-08-01 00:00:00pages
318-75issue
4eissn
0098-2997issn
1872-9452pii
S0098-2997(12)00024-6journal_volume
33pub_type
杂志文章,评审abstract：:The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.017
更新日期：2013-10-01 00:00:00
abstract：:Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.11.005
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abstract：:Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.05.003
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abstract：:Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/s0098-2997(97)00011-3
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.12.004
更新日期：2018-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.02.006
更新日期：2010-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2004.06.003
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.03.003
更新日期：2018-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-08-13 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2007.09.016
更新日期：2008-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2009.12.005
更新日期：2010-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2011.10.003
更新日期：2012-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.01.007
更新日期：2018-06-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.08.001
更新日期：2013-07-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.05.002
更新日期：2019-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0098-2997(94)90018-3
更新日期：1994-01-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2004.02.012
更新日期：2004-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.10.005
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2018-10-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2020-07-20 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2017-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2015.05.001
更新日期：2015-11-01 00:00:00
abstract：:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.06.005
更新日期：2019-10-01 00:00:00
abstract：:RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.004
更新日期：2007-02-01 00:00:00
