Anti-inflammatory properties of alpha- and gamma-tocopherol.

abstract：:Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...

journal_title：Molecular aspects of medicine

authors： O'Reilly S

更新日期：2017-04-01 00:00:00

abstract：:The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...

journal_title：Molecular aspects of medicine

authors： Mason JB,Tang SY

更新日期：2017-02-01 00:00:00

abstract：:The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...

journal_title：Molecular aspects of medicine

authors： Colon-Gonzalez F,Kim GW,Lin JE,Valentino MA,Waldman SA

更新日期：2013-02-01 00:00:00

abstract：:All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...

journal_title：Molecular aspects of medicine

authors： Kaufman BA,Li C,Soleimanpour SA

更新日期：2015-04-01 00:00:00

abstract：:This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2. SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance a...

journal_title：Molecular aspects of medicine

authors： Montalbetti N,Simonin A,Kovacs G,Hediger MA

更新日期：2013-04-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been frequently implicated in the initiation and promotion phases of carcinogenesis. Antioxidant enzymes, which can antagonize this process, are lowered in a number of malignancies. The enzyme most commonly decreased is the mitochondrial Mn-containing superoxide dismutase (MnSOD) enc...

journal_title：Molecular aspects of medicine

authors： Borrello S,De Leo ME,Galeotti T

更新日期：1993-01-01 00:00:00

abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...

journal_title：Molecular aspects of medicine

authors： Catalano MG,Poli R,Pugliese M,Fortunati N,Boccuzzi G

更新日期：2010-04-01 00:00:00

abstract：:Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process det...

journal_title：Molecular aspects of medicine

authors： Weiskirchen R,Weiskirchen S,Tacke F

更新日期：2019-02-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...

journal_title：Molecular aspects of medicine

authors： Weikel KA,Chiu CJ,Taylor A

更新日期：2012-08-01 00:00:00

abstract：:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...

journal_title：Molecular aspects of medicine

authors： Awasthi YC,Sharma R,Cheng JZ,Yang Y,Sharma A,Singhal SS,Awasthi S

更新日期：2003-08-01 00:00:00

abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...

journal_title：Molecular aspects of medicine

authors： Winklhofer-Roob BM,Rock E,Ribalta J,Shmerling DH,Roob JM

更新日期：2003-12-01 00:00:00

abstract：:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New...

journal_title：Molecular aspects of medicine

authors： Crane FL,Navas P

更新日期：1997-01-01 00:00:00

abstract：:Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...

journal_title：Molecular aspects of medicine

authors： Sousa-Victor P,Muñoz-Cánoves P

更新日期：2016-08-01 00:00:00

abstract：:Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversi...

journal_title：Molecular aspects of medicine

authors： Stankovic-Valentin N,Melchior F

更新日期：2018-10-01 00:00:00

abstract：:L-Carnitine (L-C) is a naturally occurring quaternary ammonium compound endogenous in all mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty ...

journal_title：Molecular aspects of medicine

authors： Virmani A,Binienda Z

更新日期：2004-10-01 00:00:00

abstract：:Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia or solid tumor...

journal_title：Molecular aspects of medicine

authors： Sivori S,Pende D,Quatrini L,Pietra G,Della Chiesa M,Vacca P,Tumino N,Moretta F,Mingari MC,Locatelli F,Moretta L

更新日期：2020-08-13 00:00:00

abstract：:Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Oteiza PI,Galleano M

更新日期：2018-06-01 00:00:00

abstract：:The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...

journal_title：Molecular aspects of medicine

authors： Van Prooyen N,Andresen V,Gold H,Bialuk I,Pise-Masison C,Franchini G

更新日期：2010-10-01 00:00:00

abstract：:Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...

journal_title：Molecular aspects of medicine

authors： IJsselsteijn ME,Sanz-Pamplona R,Hermitte F,de Miranda NFCC

更新日期：2019-10-01 00:00:00

abstract：:Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated by two main mechanisms: by adjusting the rates of synthesis and of export from cells. Some of the proteins responsible for GSH exp...

journal_title：Molecular aspects of medicine

authors： Ballatori N,Krance SM,Marchan R,Hammond CL

更新日期：2009-02-01 00:00:00

abstract：:Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...

journal_title：Molecular aspects of medicine

authors： McBride M,Rida PC,Aneja R

更新日期：2015-11-01 00:00:00

abstract：:Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...

journal_title：Molecular aspects of medicine

authors： Murphy C,Withrow J,Hunter M,Liu Y,Tang YL,Fulzele S,Hamrick MW

更新日期：2018-04-01 00:00:00

abstract：:The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...

journal_title：Molecular aspects of medicine

authors： Fredman G,Spite M

更新日期：2017-12-01 00:00:00

abstract：:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...

journal_title：Molecular aspects of medicine

authors： Murphy N,Moreno V,Hughes DJ,Vodicka L,Vodicka P,Aglago EK,Gunter MJ,Jenab M

更新日期：2019-10-01 00:00:00

abstract：:Carnosine and related dipeptides such as anserine are naturally-occurring histidine-containing compounds. They are found in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. The biological role of these dipeptides are conjectur...

journal_title：Molecular aspects of medicine

authors： Quinn PJ,Boldyrev AA,Formazuyk VE

更新日期：1992-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrh...

journal_title：Molecular aspects of medicine

authors： Craxì A,Laffi G,Zignego AL

更新日期：2008-02-01 00:00:00

abstract：:Peroxisomes were long believed to play only a minor role in cellular metabolism but it is now clear that they catalyze a number of important functions. The importance of peroxisomes in humans is stressed by the existence of a group of genetic diseases in man in which one or more peroxisomal functions are impaired. Mos...

journal_title：Molecular aspects of medicine

authors： Wanders RJ,Tager JM

更新日期：1998-04-01 00:00:00

abstract：:The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patien...

journal_title：Molecular aspects of medicine

authors： Farzi A,Hassan AM,Zenz G,Holzer P

更新日期：2019-04-01 00:00:00

abstract：:Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...

journal_title：Molecular aspects of medicine

authors： Oteiza PI,Mackenzie GG,Verstraeten SV

更新日期：2004-02-01 00:00:00

abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...

journal_title：Molecular aspects of medicine

authors： Armeni T,Tomasetti M,Svegliati Baroni S,Saccucci F,Marra M,Pieri C,Littarru GP,Principato G,Battino M

更新日期：1997-01-01 00:00:00