Abstract:
:Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrhosis and hepatocellular carcinoma and on the other hand several extrahepatic diseases including, first, mixed cryoglobulinemia and lymphoma. The association between hepatic (hepatocellular carcinoma) and extrahepatic (lymphoma, thyroid cancer) malignancies has justified the inclusion of HCV among human cancer viruses. The pathogenesis of HCV-related sequelae (hepatic or extrahepatic) is not fully understood representing a challenge of prime importance in light of the optimization of clinico-therapeutic management of these patients. Combined treatment with pegylated interferon plus ribavirin is presently the first-line, gold standard treatment of most HCV-related diseases. However, mainly in the case of extrahepatic manifestations, a cautious approach to the patient, with a case to case accurate tailoring of therapy is frequently requested. The present review will outline the principal aspects of such HCV-induced systemic disease focusing on extrahepatic manifestations.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Craxì A,Laffi G,Zignego ALdoi
10.1016/j.mam.2007.09.017subject
Has Abstractpub_date
2008-02-01 00:00:00pages
85-95issue
1-2eissn
0098-2997issn
1872-9452pii
S0098-2997(07)00101-Xjournal_volume
29pub_type
杂志文章,评审abstract::The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...
journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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