Hepatitis C virus (HCV) infection: a systemic disease.


:Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrhosis and hepatocellular carcinoma and on the other hand several extrahepatic diseases including, first, mixed cryoglobulinemia and lymphoma. The association between hepatic (hepatocellular carcinoma) and extrahepatic (lymphoma, thyroid cancer) malignancies has justified the inclusion of HCV among human cancer viruses. The pathogenesis of HCV-related sequelae (hepatic or extrahepatic) is not fully understood representing a challenge of prime importance in light of the optimization of clinico-therapeutic management of these patients. Combined treatment with pegylated interferon plus ribavirin is presently the first-line, gold standard treatment of most HCV-related diseases. However, mainly in the case of extrahepatic manifestations, a cautious approach to the patient, with a case to case accurate tailoring of therapy is frequently requested. The present review will outline the principal aspects of such HCV-induced systemic disease focusing on extrahepatic manifestations.


Mol Aspects Med


Craxì A,Laffi G,Zignego AL




Has Abstract


2008-02-01 00:00:00














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    abstract::In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Altinoz MA,Elmaci İ,Hacimuftuoglu A,Ozpinar A,Hacker E,Ozpinar A

    更新日期:2020-07-20 00:00:00

  • Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

    abstract::Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversi...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Stankovic-Valentin N,Melchior F

    更新日期:2018-10-01 00:00:00

  • Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration.

    abstract::Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章


    authors: Sinatra ST

    更新日期:1997-01-01 00:00:00

  • Folate status and colorectal cancer risk: A 2016 update.

    abstract::The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Mason JB,Tang SY

    更新日期:2017-02-01 00:00:00

  • Obesity pharmacotherapy: what is next?

    abstract::The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Colon-Gonzalez F,Kim GW,Lin JE,Valentino MA,Waldman SA

    更新日期:2013-02-01 00:00:00

  • Growing tumor vessels: more than one way to skin a cat - implications for angiogenesis targeted cancer therapies.

    abstract::The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Leite de Oliveira R,Hamm A,Mazzone M

    更新日期:2011-04-01 00:00:00

  • Angiogenesis meets immunology: cytokine gene therapy of cancer.

    abstract::Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host inflammatory cells followed by inhibition of tumor growth. This local effect is often accompanied by systemic protection mediated by the immune system, mainly by CD8(+) T and NK cells. On this basis, cytokine gene-transd...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Minuzzo S,Moserle L,Indraccolo S,Amadori A

    更新日期:2007-02-01 00:00:00

  • Brain water channel proteins in health and disease.

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Benga O,Huber VJ

    更新日期:2012-10-01 00:00:00

  • Carnosine: its properties, functions and potential therapeutic applications.

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    pub_type: 杂志文章,评审


    authors: Quinn PJ,Boldyrev AA,Formazuyk VE

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Watkins BA

    更新日期:2018-12-01 00:00:00

  • Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release.

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Kaufman BA,Li C,Soleimanpour SA

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Sousa-Victor P,Muñoz-Cánoves P

    更新日期:2016-08-01 00:00:00

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Winklhofer-Roob BM,Rock E,Ribalta J,Shmerling DH,Roob JM

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    abstract::17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Ascenzi P,Bocedi A,Marino M

    更新日期:2006-08-01 00:00:00

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Murphy C,Withrow J,Hunter M,Liu Y,Tang YL,Fulzele S,Hamrick MW

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    abstract::Metastasis is a complex non-stochastic process that is most likely the result of genetic and epigenetic interactions of a wide variety of genes. The search for a single gene which can encompass such a pleiotropic response as to account for the observed phenotypic characteristics of metastatic tumour populations has be...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Weiskirchen R,Weiskirchen S,Tacke F

    更新日期:2019-02-01 00:00:00

  • Epigenetics in fibrosis.

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: O'Reilly S

    更新日期:2017-04-01 00:00:00

  • Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors.

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Oteiza PI,Mackenzie GG,Verstraeten SV

    更新日期:2004-02-01 00:00:00

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Van Prooyen N,Andresen V,Gold H,Bialuk I,Pise-Masison C,Franchini G

    更新日期:2010-10-01 00:00:00

  • The SLCO (former SLC21) superfamily of transporters.

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Hagenbuch B,Stieger B

    更新日期:2013-04-01 00:00:00

  • Lipid metabolism in peroxisomes in relation to human disease.

    abstract::Peroxisomes were long believed to play only a minor role in cellular metabolism but it is now clear that they catalyze a number of important functions. The importance of peroxisomes in humans is stressed by the existence of a group of genetic diseases in man in which one or more peroxisomal functions are impaired. Mos...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Wanders RJ,Tager JM

    更新日期:1998-04-01 00:00:00

  • Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing.

    abstract::Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章


    authors: Armeni T,Tomasetti M,Svegliati Baroni S,Saccucci F,Marra M,Pieri C,Littarru GP,Principato G,Battino M

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  • Navigating the site for embryo implantation: biomechanical and molecular regulation of intrauterine embryo distribution.

    abstract::The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Chen Q,Zhang Y,Elad D,Jaffa AJ,Cao Y,Ye X,Duan E

    更新日期:2013-10-01 00:00:00

  • Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.

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    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Ballatori N,Krance SM,Marchan R,Hammond CL

    更新日期:2009-02-01 00:00:00

  • Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?

    abstract::ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes ...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Galano JM,Roy J,Durand T,Lee JC,Le Guennec JY,Oger C,Demion M

    更新日期:2018-12-01 00:00:00

  • The ABCs of membrane transporters in health and disease (SLC series): introduction.

    abstract::The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be foun...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Hediger MA,Clémençon B,Burrier RE,Bruford EA

    更新日期:2013-04-01 00:00:00

  • The role of brown and beige adipose tissue in glycaemic control.

    abstract::For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Klepac K,Georgiadi A,Tschöp M,Herzig S

    更新日期:2019-08-01 00:00:00

  • Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex.

    abstract::There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Bhutto I,Lutty G

    更新日期:2012-08-01 00:00:00

  • Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.

    abstract::The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patien...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审


    authors: Farzi A,Hassan AM,Zenz G,Holzer P

    更新日期:2019-04-01 00:00:00