Hepatitis C virus (HCV) infection: a systemic disease.

abstract：:The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...

journal_title：Molecular aspects of medicine

authors： Hagenbuch B,Stieger B

更新日期：2013-04-01 00:00:00

abstract：:Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...

journal_title：Molecular aspects of medicine

authors： McBride M,Rida PC,Aneja R

更新日期：2015-11-01 00:00:00

abstract：:Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Oteiza PI,Galleano M

更新日期：2018-06-01 00:00:00

abstract：:Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...

journal_title：Molecular aspects of medicine

authors： Silva L,Subiabre M,Araos J,Sáez T,Salsoso R,Pardo F,Leiva A,San Martín R,Toledo F,Sobrevia L

更新日期：2017-06-01 00:00:00

abstract：:The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...

journal_title：Molecular aspects of medicine

authors： Mason JB,Tang SY

更新日期：2017-02-01 00:00:00

abstract：:Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...

journal_title：Molecular aspects of medicine

authors： O'Reilly S

更新日期：2017-04-01 00:00:00

abstract：:Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid system (ECS) has emerged as a focal point to...

journal_title：Molecular aspects of medicine

authors： Watkins BA

更新日期：2018-12-01 00:00:00

abstract：:The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...

journal_title：Molecular aspects of medicine

authors： Van Prooyen N,Andresen V,Gold H,Bialuk I,Pise-Masison C,Franchini G

更新日期：2010-10-01 00:00:00

abstract：:The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...

journal_title：Molecular aspects of medicine

authors： Fredman G,Spite M

更新日期：2017-12-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...

journal_title：Molecular aspects of medicine

authors： Weikel KA,Chiu CJ,Taylor A

更新日期：2012-08-01 00:00:00

abstract：:ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes ...

journal_title：Molecular aspects of medicine

authors： Galano JM,Roy J,Durand T,Lee JC,Le Guennec JY,Oger C,Demion M

更新日期：2018-12-01 00:00:00

abstract：:The involvement of many zinc metalloproteinases belonging to the metzincin family with a variety of pathological states raises the possibility of therapeutic intervention using synthetic inhibitors with appropriate selectivity. Knowledge of the catalytic domain 3D-structures for various members of the metzincin family...

journal_title：Molecular aspects of medicine

authors： Yiotakis A,Dive V

更新日期：2008-10-01 00:00:00

abstract：:Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...

journal_title：Molecular aspects of medicine

authors： Udali S,Guarini P,Moruzzi S,Choi SW,Friso S

更新日期：2013-07-01 00:00:00

abstract：:Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...

journal_title：Molecular aspects of medicine

authors： Keaney JF Jr

更新日期：2000-08-01 00:00:00

abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...

journal_title：Molecular aspects of medicine

authors： Winklhofer-Roob BM,Rock E,Ribalta J,Shmerling DH,Roob JM

更新日期：2003-12-01 00:00:00

abstract：:Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversi...

journal_title：Molecular aspects of medicine

authors： Stankovic-Valentin N,Melchior F

更新日期：2018-10-01 00:00:00

abstract：:Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...

journal_title：Molecular aspects of medicine

authors： Oteiza PI,Mackenzie GG,Verstraeten SV

更新日期：2004-02-01 00:00:00

abstract：:Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings...

journal_title：Molecular aspects of medicine

authors： Suzuki Y,Taniyama M,Muramatsu T,Atsumi Y,Hosokawa K,Asahina T,Shimada A,Murata C,Matsuoka K

更新日期：1997-01-01 00:00:00

abstract：:The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...

journal_title：Molecular aspects of medicine

authors： Grolleman JE,Díaz-Gay M,Franch-Expósito S,Castellví-Bel S,de Voer RM

更新日期：2019-10-01 00:00:00

abstract：:When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane st...

journal_title：Molecular aspects of medicine

authors： Monastyrska I,Klionsky DJ

更新日期：2006-10-01 00:00:00

abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...

journal_title：Molecular aspects of medicine

authors： Armeni T,Tomasetti M,Svegliati Baroni S,Saccucci F,Marra M,Pieri C,Littarru GP,Principato G,Battino M

更新日期：1997-01-01 00:00:00

abstract：:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...

journal_title：Molecular aspects of medicine

authors： Das M,Das DK

更新日期：2010-12-01 00:00:00

abstract：:The oxidation of low density lipoprotein (LDL) is now commonly regarded as an important early event in atherogenesis. As such there is considerable interest in the ability of antioxidant supplementation to attenuate LDL oxidation and hence atherosclerosis. A majority of studies on LDL antioxidation have focused on alp...

journal_title：Molecular aspects of medicine

authors： Thomas SR,Neuzil J,Stocker R

更新日期：1997-01-01 00:00:00

abstract：:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...

journal_title：Molecular aspects of medicine

authors： Bargossi AM,Grossi G,Fiorella PL,Gaddi A,Di Giulio R,Battino M

更新日期：1994-01-01 00:00:00

abstract：:Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, w...

journal_title：Molecular aspects of medicine

authors： Reiter E,Jiang Q,Christen S

更新日期：2007-10-01 00:00:00

abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...

journal_title：Molecular aspects of medicine

authors： Catalano MG,Poli R,Pugliese M,Fortunati N,Boccuzzi G

更新日期：2010-04-01 00:00:00

abstract：:About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...

journal_title：Molecular aspects of medicine

authors： Schiöth HB,Roshanbin S,Hägglund MG,Fredriksson R

更新日期：2013-04-01 00:00:00

abstract：:Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...

journal_title：Molecular aspects of medicine

authors： Norton RL,Hoffmann PR

更新日期：2012-02-01 00:00:00

abstract：:Metastasis is a complex non-stochastic process that is most likely the result of genetic and epigenetic interactions of a wide variety of genes. The search for a single gene which can encompass such a pleiotropic response as to account for the observed phenotypic characteristics of metastatic tumour populations has be...

journal_title：Molecular aspects of medicine

authors： Dear TN,Kefford RF

更新日期：1990-01-01 00:00:00

abstract：:Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...

journal_title：Molecular aspects of medicine

authors： Murphy C,Withrow J,Hunter M,Liu Y,Tang YL,Fulzele S,Hamrick MW

更新日期：2018-04-01 00:00:00