Abstract：
:When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane structure within the cell, which encloses the material to be degraded into a vesicle called an autophagosome. The autophagosome subsequently fuses with a lysosome/vacuole whose hydrolytic enzymes degrade the sequestered organelle. Degradation of peroxisomes is a specific type of autophagy, which occurs in a selective manner and has been mostly studied in yeast. Recently, it was reported that a similar selective process of autophagy occurs in mammalian cells with proliferated peroxisomes. Here we discuss characteristics of the autophagy of peroxisomes in mammalian cells and present a comprehensive model of their likely mechanism of degradation on the basis of known and common elements from other systems.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Monastyrska I,Klionsky DJdoi
10.1016/j.mam.2006.08.004subject
Has Abstractpub_date
2006-10-01 00:00:00pages
483-94issue
5-6eissn
0098-2997issn
1872-9452pii
S0098-2997(06)00022-7journal_volume
27pub_type
杂志文章,评审abstract：:The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.02.003
更新日期：2017-12-01 00:00:00
abstract：:For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.07.001
更新日期：2019-08-01 00:00:00
abstract：:Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2015.05.001
更新日期：2015-11-01 00:00:00
abstract：:Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.12.004
更新日期：2018-12-01 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrh...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2007.09.017
更新日期：2008-02-01 00:00:00
abstract：:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(03)00017-7
更新日期：2003-08-01 00:00:00
abstract：:17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.07.001
更新日期：2006-08-01 00:00:00
abstract：:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.09.001
更新日期：2010-12-01 00:00:00
abstract：:All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2015.01.004
更新日期：2015-04-01 00:00:00
abstract：:The vitamin D endocrine system plays a central role in mineral ion homeostasis through the actions of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], on the intestine, bone, parathyroid gland, and kidney. The main function of 1,25(OH)(2)D(3) is to promote the dietary absorption of calcium and phos...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2008.04.001
更新日期：2008-12-01 00:00:00
abstract：:Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia or solid tumor...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2020.100870
更新日期：2020-08-13 00:00:00
abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.02.006
更新日期：2010-04-01 00:00:00
abstract：:Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.013
更新日期：2013-04-01 00:00:00
abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90039-6
更新日期：1994-01-01 00:00:00
abstract：:Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.08.002
更新日期：2018-12-01 00:00:00
abstract：:About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.012
更新日期：2013-04-01 00:00:00
abstract：:RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.004
更新日期：2007-02-01 00:00:00
abstract：:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.06.005
更新日期：2019-10-01 00:00:00
abstract：:Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.11.002
更新日期：2017-06-01 00:00:00
abstract：:The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.10.009
更新日期：2013-04-01 00:00:00
abstract：:The involvement of many zinc metalloproteinases belonging to the metzincin family with a variety of pathological states raises the possibility of therapeutic intervention using synthetic inhibitors with appropriate selectivity. Knowledge of the catalytic domain 3D-structures for various members of the metzincin family...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2008.06.001
更新日期：2008-10-01 00:00:00
abstract：:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...
journal_title：Molecular aspects of medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0098-2997(94)90028-0
更新日期：1994-01-01 00:00:00
abstract：:Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid system (ECS) has emerged as a focal point to...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：:Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host inflammatory cells followed by inhibition of tumor growth. This local effect is often accompanied by systemic protection mediated by the immune system, mainly by CD8(+) T and NK cells. On this basis, cytokine gene-transd...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.008
更新日期：2007-02-01 00:00:00
abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/s0098-2997(97)00021-6
更新日期：1997-01-01 00:00:00
abstract：:Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.11.005
更新日期：2018-04-01 00:00:00
abstract：:The oxidation of low density lipoprotein (LDL) is now commonly regarded as an important early event in atherogenesis. As such there is considerable interest in the ability of antioxidant supplementation to attenuate LDL oxidation and hence atherosclerosis. A majority of studies on LDL antioxidation have focused on alp...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(97)00031-9
更新日期：1997-01-01 00:00:00
abstract：:Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(00)00005-4
更新日期：2000-08-01 00:00:00
abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.09.006
更新日期：2010-12-01 00:00:00
abstract：:Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2011.10.003
更新日期：2012-02-01 00:00:00
