Abstract：
:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particularly lifestyle and diet. It is established that physical inactivity, obesity and some dietary factors (red/processed meats, alcohol) are positively associated with CRC, while healthy lifestyle habits show inverse associations. Mechanistic evidence shows that lifestyle and dietary components that contribute to energy excess are linked with increased CRC via metabolic dysfunction, inflammation, oxidative stress, bacterial dysbiosis and breakdown of gut barrier integrity while the reverse is apparent for components associated with decreased risk. This chapter will review the available evidence on lifestyle and dietary factors in CRC etiology and their underlying mechanisms in CRC development. This short review will also touch upon available information on potential gene-environment interactions, molecular sub-types of CRC and anatomical sub-sites within the colorectum.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Murphy N,Moreno V,Hughes DJ,Vodicka L,Vodicka P,Aglago EK,Gunter MJ,Jenab Mdoi
10.1016/j.mam.2019.06.005subject
Has Abstractpub_date
2019-10-01 00:00:00pages
2-9eissn
0098-2997issn
1872-9452pii
S0098-2997(19)30033-0journal_volume
69pub_type
杂志文章,评审abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90018-3
更新日期：1994-01-01 00:00:00
abstract：:Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.08.001
更新日期：2013-07-01 00:00:00
abstract：:This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2. SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance a...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2013.01.002
更新日期：2013-04-01 00:00:00
abstract：:Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.05.003
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abstract：:Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues. Although its physiological role has not been completely understood yet, many beneficial actions have been attributed to carnosine, such as being an antioxidant, antiglycating and io...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2011.10.009
更新日期：2011-08-01 00:00:00
abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(03)00035-9
更新日期：2003-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.013
更新日期：2013-04-01 00:00:00
abstract：:Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2004.02.012
更新日期：2004-02-01 00:00:00
abstract：:RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.004
更新日期：2007-02-01 00:00:00
abstract：:ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.03.003
更新日期：2018-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.10.001
更新日期：2018-12-01 00:00:00
abstract：:The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patien...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.11.003
更新日期：2019-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.04.005
更新日期：2012-08-01 00:00:00
abstract：:Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/s0098-2997(97)00011-3
更新日期：1997-01-01 00:00:00
abstract：:L-Carnitine (L-C) is a naturally occurring quaternary ammonium compound endogenous in all mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2004.06.003
更新日期：2004-10-01 00:00:00
abstract：:The Notch receptors are a family of transmembrane proteins that mediate direct cell-cell interactions and control numerous cell-fate specifications in humans. The extracellular domains of mammalian Notch proteins contain 29-36 tandem epidermal growth factor-like (EGF) repeats, most of which have O-linked glycan modifi...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/j.mam.2020.100938
更新日期：2020-12-16 00:00:00
abstract：:Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, w...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2007.01.003
更新日期：2007-10-01 00:00:00
abstract：:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(97)00016-2
更新日期：1997-01-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.07.001
更新日期：2019-08-01 00:00:00
abstract：:In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2020-07-20 00:00:00
abstract：:Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2017-04-01 00:00:00
abstract：:The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.03.008
更新日期：2012-10-01 00:00:00
abstract：:Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2012-02-01 00:00:00
abstract：:The vitamin D endocrine system plays a central role in mineral ion homeostasis through the actions of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], on the intestine, bone, parathyroid gland, and kidney. The main function of 1,25(OH)(2)D(3) is to promote the dietary absorption of calcium and phos...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2008.04.001
更新日期：2008-12-01 00:00:00
abstract：:All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2015.01.004
更新日期：2015-04-01 00:00:00
abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/s0098-2997(97)00021-6
更新日期：1997-01-01 00:00:00
abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90039-6
更新日期：1994-01-01 00:00:00
abstract：:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(03)00017-7
更新日期：2003-08-01 00:00:00
abstract：:Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.12.004
更新日期：2018-12-01 00:00:00
