Abstract：
:Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on genetic and environmental factors and, when it takes place in adult stem cells, it could play an important role in aging, although the underlying molecular mechanisms are still largely unknown.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Huidobro C,Fernandez AF,Fraga MFdoi
10.1016/j.mam.2012.06.006subject
Has Abstractpub_date
2013-07-01 00:00:00pages
765-81issue
4eissn
0098-2997issn
1872-9452pii
S0098-2997(12)00078-7journal_volume
34pub_type
杂志文章,评审abstract：:The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...
journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2000-08-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
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journal_title：Molecular aspects of medicine
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doi：10.1016/j.mam.2004.06.003
更新日期：2004-10-01 00:00:00
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.03.008
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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abstract：:Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2018-04-01 00:00:00
abstract：:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.08.002
更新日期：2018-12-01 00:00:00
