Abstract:
:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New studies show that the presence of coenzyme Q in other cellular membranes has dynamic rather than passive significance. Coenzyme Q functions in the plasma membrane electron transport involved in activation of signalling protein kinases related to gene activation for cellular proliferation. Furthermore, the antioxidant potential of the reduced coenzyme Q is now taken on a new significance in the evidence that the reduced quinone can act to maintain tocopherol in the reduced state in membranes and ascorbate reduced both inside and outside the cell.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Crane FL,Navas Pdoi
10.1016/s0098-2997(97)00016-2subject
Has Abstractpub_date
1997-01-01 00:00:00pages
S1-6eissn
0098-2997issn
1872-9452pii
S0098-2997(97)00016-2journal_volume
18 Supplpub_type
杂志文章,评审abstract::Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrh...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2007.09.017
更新日期:2008-02-01 00:00:00
abstract::Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, w...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2007.01.003
更新日期:2007-10-01 00:00:00
abstract::Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.11.002
更新日期:2017-06-01 00:00:00
abstract::There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.04.005
更新日期:2012-08-01 00:00:00
abstract::Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.08.001
更新日期:2013-07-01 00:00:00
abstract::Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(00)00005-4
更新日期:2000-08-01 00:00:00
abstract::Reactive oxygen species (ROS) have been frequently implicated in the initiation and promotion phases of carcinogenesis. Antioxidant enzymes, which can antagonize this process, are lowered in a number of malignancies. The enzyme most commonly decreased is the mitochondrial Mn-containing superoxide dismutase (MnSOD) enc...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/0098-2997(93)90012-3
更新日期:1993-01-01 00:00:00
abstract::The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...
journal_title:Molecular aspects of medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0098-2997(94)90028-0
更新日期:1994-01-01 00:00:00
abstract::The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be foun...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.12.009
更新日期:2013-04-01 00:00:00
abstract::Carnosine and related dipeptides such as anserine are naturally-occurring histidine-containing compounds. They are found in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. The biological role of these dipeptides are conjectur...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/0098-2997(92)90006-l
更新日期:1992-01-01 00:00:00
abstract::RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.12.004
更新日期:2007-02-01 00:00:00
abstract::Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/j.mam.2020.100923
更新日期:2020-11-04 00:00:00
abstract::The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patien...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.11.003
更新日期:2019-04-01 00:00:00
abstract::For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.07.001
更新日期:2019-08-01 00:00:00
abstract::The vitamin D endocrine system plays a central role in mineral ion homeostasis through the actions of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], on the intestine, bone, parathyroid gland, and kidney. The main function of 1,25(OH)(2)D(3) is to promote the dietary absorption of calcium and phos...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2008.04.001
更新日期:2008-12-01 00:00:00
abstract::The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.10.009
更新日期:2013-04-01 00:00:00
abstract::The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.03.008
更新日期:2012-10-01 00:00:00
abstract::Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2010.09.001
更新日期:2010-12-01 00:00:00
abstract::Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversi...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.07.002
更新日期:2018-10-01 00:00:00
abstract::Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated by two main mechanisms: by adjusting the rates of synthesis and of export from cells. Some of the proteins responsible for GSH exp...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2008.08.004
更新日期:2009-02-01 00:00:00
abstract::Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.05.003
更新日期:2019-10-01 00:00:00
abstract::The Notch receptors are a family of transmembrane proteins that mediate direct cell-cell interactions and control numerous cell-fate specifications in humans. The extracellular domains of mammalian Notch proteins contain 29-36 tandem epidermal growth factor-like (EGF) repeats, most of which have O-linked glycan modifi...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/j.mam.2020.100938
更新日期:2020-12-16 00:00:00
abstract::Angiogenesis is integral to the growth and metastatic spread of tumours, and its targeting is an effective anti-tumour strategy. Currently hundreds of anti-angiogenic therapeutics exist in varying stages of development, a number of which have recently gained US Food and Drug Administration (FDA) approval for the treat...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2009.12.005
更新日期:2010-02-01 00:00:00
abstract::The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.04.001
更新日期:2011-04-01 00:00:00
abstract::Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.02.002
更新日期:2016-08-01 00:00:00
abstract::Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues. Although its physiological role has not been completely understood yet, many beneficial actions have been attributed to carnosine, such as being an antioxidant, antiglycating and io...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.10.009
更新日期:2011-08-01 00:00:00
abstract::Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.12.004
更新日期:2018-12-01 00:00:00
abstract::The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.05.002
更新日期:2019-10-01 00:00:00
abstract::Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(03)00035-9
更新日期:2003-12-01 00:00:00
abstract::Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.11.005
更新日期:2018-04-01 00:00:00