Abstract：
:Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms including those controlled by small non-coding RNAs (miRNAs). The impact of epigenetic mechanisms in cardiovascular pathophysiology is now emerging as a major player in the interface between genotype to phenotype variability. This topic of research has strict implications on disease development and progression, and opens up possible novel preventive strategies in cardiovascular disease. An important aspect of epigenetic mechanisms is that they are potentially reversible and may be influenced by nutritional-environmental factors and through gene-environment interactions, all of which have an important role in complex, multifactorial diseases such as those affecting the cardiovascular system. Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored. The study of epigenetic markers is, therefore, a very promising frontier of science which may aid in a deeper understanding of molecular mechanisms underlying the modulation of gene expression in the biomolecule pathways linked to cardiovascular diseases. This review focuses on up-to-date knowledge pertaining to the role of epigenetics, from DNA methylation to miRNAs, in major cardiovascular diseases such as ischemic heart disease, hypertension, heart failure and stroke.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Udali S,Guarini P,Moruzzi S,Choi SW,Friso Sdoi
10.1016/j.mam.2012.08.001subject
Has Abstractpub_date
2013-07-01 00:00:00pages
883-901issue
4eissn
0098-2997issn
1872-9452pii
S0098-2997(12)00113-6journal_volume
34pub_type
杂志文章,评审abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90039-6
更新日期：1994-01-01 00:00:00
abstract：:Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.11.005
更新日期：2018-04-01 00:00:00
abstract：:Reactive oxygen species (ROS) have been frequently implicated in the initiation and promotion phases of carcinogenesis. Antioxidant enzymes, which can antagonize this process, are lowered in a number of malignancies. The enzyme most commonly decreased is the mitochondrial Mn-containing superoxide dismutase (MnSOD) enc...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(93)90012-3
更新日期：1993-01-01 00:00:00
abstract：:Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.01.007
更新日期：2018-06-01 00:00:00
abstract：:About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.012
更新日期：2013-04-01 00:00:00
abstract：:Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.07.013
更新日期：2013-04-01 00:00:00
abstract：:Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(00)00005-4
更新日期：2000-08-01 00:00:00
abstract：:The oxidation of low density lipoprotein (LDL) is now commonly regarded as an important early event in atherogenesis. As such there is considerable interest in the ability of antioxidant supplementation to attenuate LDL oxidation and hence atherosclerosis. A majority of studies on LDL antioxidation have focused on alp...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(97)00031-9
更新日期：1997-01-01 00:00:00
abstract：:The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.10.009
更新日期：2013-04-01 00:00:00
abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(03)00035-9
更新日期：2003-12-01 00:00:00
abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.09.006
更新日期：2010-12-01 00:00:00
abstract：:All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2015.01.004
更新日期：2015-04-01 00:00:00
abstract：:For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.07.001
更新日期：2019-08-01 00:00:00
abstract：:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avast...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.02.005
更新日期：2010-04-01 00:00:00
abstract：:Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.05.003
更新日期：2019-10-01 00:00:00
abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.02.006
更新日期：2010-04-01 00:00:00
abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(94)90018-3
更新日期：1994-01-01 00:00:00
abstract：:The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.02.003
更新日期：2017-12-01 00:00:00
abstract：:Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.12.004
更新日期：2018-12-01 00:00:00
abstract：:Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2018.08.002
更新日期：2018-12-01 00:00:00
abstract：:The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.03.008
更新日期：2012-10-01 00:00:00
abstract：:Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/j.mam.2020.100923
更新日期：2020-11-04 00:00:00
abstract：:Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.02.002
更新日期：2016-08-01 00:00:00
abstract：:There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.04.005
更新日期：2012-08-01 00:00:00
abstract：:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2019.06.005
更新日期：2019-10-01 00:00:00
abstract：:Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2017.09.006
更新日期：2018-04-01 00:00:00
abstract：:RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.004
更新日期：2007-02-01 00:00:00
abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/s0098-2997(97)00021-6
更新日期：1997-01-01 00:00:00
abstract：:The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.07.001
更新日期：2010-10-01 00:00:00
abstract：:This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2. SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance a...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2013.01.002
更新日期：2013-04-01 00:00:00
