Abstract:
:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor (VEGF), and cetuximab (Erbitux), an inhibitor of epithelial growth factor receptor (EGFR). Although these biologicals have entered clinical routine due to their encouraging results, their effect has been shown to be limited due to adaptation or previously existing resistance of tumor cells. This has been clearly shown in the case of patients with mutations of K-ras, which lead to resistance against cetuximab. Therefore, several new pathways are currently investigated for therapeutic targeting in CRC. These include WNT-signaling, downstream mediators of EGFR as the mitogen-activated protein kinase (MAPK)- or the phosphatidylinositol 3-kinase (PI3K)-pathway, the hypoxia response system involving hypoxia inducible factor-1 (HIF-1), mechanisms of tumor development following chronic inflammation, and many others. This article will review new molecular targets for the treatment of CRC and discuss possible implications for clinical therapy.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Waldner MJ,Neurath MFdoi
10.1016/j.mam.2010.02.005subject
Has Abstractpub_date
2010-04-01 00:00:00pages
171-8issue
2eissn
0098-2997issn
1872-9452pii
S0098-2997(10)00006-3journal_volume
31pub_type
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journal_title:Molecular aspects of medicine
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doi:10.1016/j.mam.2018.01.007
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2013.01.002
更新日期:2013-04-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2015.05.001
更新日期:2015-11-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.12.004
更新日期:2007-02-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/0098-2997(93)90012-3
更新日期:1993-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.017
更新日期:2013-10-01 00:00:00
abstract::Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(97)00041-1
更新日期:1997-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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abstract::The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.10.005
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2008.08.004
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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abstract::Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
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abstract::Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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abstract::Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...
journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.09.006
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journal_title:Molecular aspects of medicine
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abstract::Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...
journal_title:Molecular aspects of medicine
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abstract::Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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