Refractory congestive heart failure successfully managed with high dose coenzyme Q10 administration.

abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...

journal_title：Molecular aspects of medicine

authors： Winklhofer-Roob BM,Rock E,Ribalta J,Shmerling DH,Roob JM

更新日期：2003-12-01 00:00:00

abstract：:The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...

journal_title：Molecular aspects of medicine

authors： Leite de Oliveira R,Hamm A,Mazzone M

更新日期：2011-04-01 00:00:00

abstract：:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avast...

journal_title：Molecular aspects of medicine

authors： Waldner MJ,Neurath MF

更新日期：2010-04-01 00:00:00

abstract：:The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...

journal_title：Molecular aspects of medicine

authors： Grolleman JE,Díaz-Gay M,Franch-Expósito S,Castellví-Bel S,de Voer RM

更新日期：2019-10-01 00:00:00

abstract：:Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...

journal_title：Molecular aspects of medicine

authors： IJsselsteijn ME,Sanz-Pamplona R,Hermitte F,de Miranda NFCC

更新日期：2019-10-01 00:00:00

abstract：:The Notch receptors are a family of transmembrane proteins that mediate direct cell-cell interactions and control numerous cell-fate specifications in humans. The extracellular domains of mammalian Notch proteins contain 29-36 tandem epidermal growth factor-like (EGF) repeats, most of which have O-linked glycan modifi...

journal_title：Molecular aspects of medicine

authors： Matsumoto K,Luther KB,Haltiwanger RS

更新日期：2020-12-16 00:00:00

abstract：:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...

journal_title：Molecular aspects of medicine

authors： Awasthi YC,Sharma R,Cheng JZ,Yang Y,Sharma A,Singhal SS,Awasthi S

更新日期：2003-08-01 00:00:00

abstract：:Angiogenesis is integral to the growth and metastatic spread of tumours, and its targeting is an effective anti-tumour strategy. Currently hundreds of anti-angiogenic therapeutics exist in varying stages of development, a number of which have recently gained US Food and Drug Administration (FDA) approval for the treat...

journal_title：Molecular aspects of medicine

authors： Park D,Dilda PJ

更新日期：2010-02-01 00:00:00

abstract：:Carnosine and related dipeptides such as anserine are naturally-occurring histidine-containing compounds. They are found in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. The biological role of these dipeptides are conjectur...

journal_title：Molecular aspects of medicine

authors： Quinn PJ,Boldyrev AA,Formazuyk VE

更新日期：1992-01-01 00:00:00

abstract：:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New...

journal_title：Molecular aspects of medicine

authors： Crane FL,Navas P

更新日期：1997-01-01 00:00:00

abstract：:Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...

journal_title：Molecular aspects of medicine

authors： Murphy C,Withrow J,Hunter M,Liu Y,Tang YL,Fulzele S,Hamrick MW

更新日期：2018-04-01 00:00:00

abstract：:The oxidation of low density lipoprotein (LDL) is now commonly regarded as an important early event in atherogenesis. As such there is considerable interest in the ability of antioxidant supplementation to attenuate LDL oxidation and hence atherosclerosis. A majority of studies on LDL antioxidation have focused on alp...

journal_title：Molecular aspects of medicine

authors： Thomas SR,Neuzil J,Stocker R

更新日期：1997-01-01 00:00:00

abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...

journal_title：Molecular aspects of medicine

authors： Weber C,Jakobsen TS,Mortensen SA,Paulsen G,Hølmer G

更新日期：1994-01-01 00:00:00

abstract：:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...

journal_title：Molecular aspects of medicine

authors： Murphy N,Moreno V,Hughes DJ,Vodicka L,Vodicka P,Aglago EK,Gunter MJ,Jenab M

更新日期：2019-10-01 00:00:00

abstract：:Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...

journal_title：Molecular aspects of medicine

authors： O'Reilly S

更新日期：2017-04-01 00:00:00

abstract：:Metastasis is a complex non-stochastic process that is most likely the result of genetic and epigenetic interactions of a wide variety of genes. The search for a single gene which can encompass such a pleiotropic response as to account for the observed phenotypic characteristics of metastatic tumour populations has be...

journal_title：Molecular aspects of medicine

authors： Dear TN,Kefford RF

更新日期：1990-01-01 00:00:00

abstract：:Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...

journal_title：Molecular aspects of medicine

authors： Sousa-Victor P,Muñoz-Cánoves P

更新日期：2016-08-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...

journal_title：Molecular aspects of medicine

authors： Weikel KA,Chiu CJ,Taylor A

更新日期：2012-08-01 00:00:00

abstract：:Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...

journal_title：Molecular aspects of medicine

authors： Silva L,Subiabre M,Araos J,Sáez T,Salsoso R,Pardo F,Leiva A,San Martín R,Toledo F,Sobrevia L

更新日期：2017-06-01 00:00:00

abstract：:Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia or solid tumor...

journal_title：Molecular aspects of medicine

authors： Sivori S,Pende D,Quatrini L,Pietra G,Della Chiesa M,Vacca P,Tumino N,Moretta F,Mingari MC,Locatelli F,Moretta L

更新日期：2020-08-13 00:00:00

abstract：:In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...

journal_title：Molecular aspects of medicine

authors： Altinoz MA,Elmaci İ,Hacimuftuoglu A,Ozpinar A,Hacker E,Ozpinar A

更新日期：2020-07-20 00:00:00

abstract：:Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...

journal_title：Molecular aspects of medicine

authors： Norton RL,Hoffmann PR

更新日期：2012-02-01 00:00:00

abstract：:The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...

journal_title：Molecular aspects of medicine

authors： Benga O,Huber VJ

更新日期：2012-10-01 00:00:00

abstract：:The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...

journal_title：Molecular aspects of medicine

authors： Chen Q,Zhang Y,Elad D,Jaffa AJ,Cao Y,Ye X,Duan E

更新日期：2013-10-01 00:00:00

abstract：:About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...

journal_title：Molecular aspects of medicine

authors： Schiöth HB,Roshanbin S,Hägglund MG,Fredriksson R

更新日期：2013-04-01 00:00:00

abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Galleano M,Verstraeten SV,Oteiza PI

更新日期：2010-12-01 00:00:00

abstract：:Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings...

journal_title：Molecular aspects of medicine

authors： Suzuki Y,Taniyama M,Muramatsu T,Atsumi Y,Hosokawa K,Asahina T,Shimada A,Murata C,Matsuoka K

更新日期：1997-01-01 00:00:00

abstract：:Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host inflammatory cells followed by inhibition of tumor growth. This local effect is often accompanied by systemic protection mediated by the immune system, mainly by CD8(+) T and NK cells. On this basis, cytokine gene-transd...

journal_title：Molecular aspects of medicine

authors： Minuzzo S,Moserle L,Indraccolo S,Amadori A

更新日期：2007-02-01 00:00:00

abstract：:The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...

journal_title：Molecular aspects of medicine

authors： Colon-Gonzalez F,Kim GW,Lin JE,Valentino MA,Waldman SA

更新日期：2013-02-01 00:00:00

abstract：:The aldehyde 4-hydroxynonenal (HNE) is a major end-product of peroxidation of membrane n-6-polyunsaturated fatty acids. Primary reactants for HNE are the amino acids cysteine, histidine and lysine, and quantitatively, proteins and peptides represent the most important group of HNE-targeted biomolecules. HNE-protein ad...

journal_title：Molecular aspects of medicine

authors： Poli G,Biasi F,Leonarduzzi G

更新日期：2008-02-01 00:00:00