听力与言语-语言病理学

行为科学

医学伦理学

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  • Diseases related to Notch glycosylation.

    abstract::The Notch receptors are a family of transmembrane proteins that mediate direct cell-cell interactions and control numerous cell-fate specifications in humans. The extracellular domains of mammalian Notch proteins contain 29-36 tandem epidermal growth factor-like (EGF) repeats, most of which have O-linked glycan modifi...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章

    doi:10.1016/j.mam.2020.100938

    authors: Matsumoto K,Luther KB,Haltiwanger RS

    更新日期:2020-12-16 00:00:00

  • Immunometabolic control of hematopoiesis.

    abstract::Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章

    doi:10.1016/j.mam.2020.100923

    authors: Hajishengallis G,Li X,Chavakis T

    更新日期:2020-11-04 00:00:00

  • NK cells and ILCs in tumor immunotherapy.

    abstract::Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia or solid tumor...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2020.100870

    authors: Sivori S,Pende D,Quatrini L,Pietra G,Della Chiesa M,Vacca P,Tumino N,Moretta F,Mingari MC,Locatelli F,Moretta L

    更新日期:2020-08-13 00:00:00

  • PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson's disease.

    abstract::In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2020.100871

    authors: Altinoz MA,Elmaci İ,Hacimuftuoglu A,Ozpinar A,Hacker E,Ozpinar A

    更新日期:2020-07-20 00:00:00

  • Colorectal cancer: A paradigmatic model for cancer immunology and immunotherapy.

    abstract::Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2019.05.003

    authors: IJsselsteijn ME,Sanz-Pamplona R,Hermitte F,de Miranda NFCC

    更新日期:2019-10-01 00:00:00

  • Somatic mutational signatures in polyposis and colorectal cancer.

    abstract::The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2019.05.002

    authors: Grolleman JE,Díaz-Gay M,Franch-Expósito S,Castellví-Bel S,de Voer RM

    更新日期:2019-10-01 00:00:00

  • Lifestyle and dietary environmental factors in colorectal cancer susceptibility.

    abstract::Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2019.06.005

    authors: Murphy N,Moreno V,Hughes DJ,Vodicka L,Vodicka P,Aglago EK,Gunter MJ,Jenab M

    更新日期:2019-10-01 00:00:00

  • The role of brown and beige adipose tissue in glycaemic control.

    abstract::For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2019.07.001

    authors: Klepac K,Georgiadi A,Tschöp M,Herzig S

    更新日期:2019-08-01 00:00:00

  • Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.

    abstract::The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patien...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.11.003

    authors: Farzi A,Hassan AM,Zenz G,Holzer P

    更新日期:2019-04-01 00:00:00

  • Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications.

    abstract::Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process det...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.06.003

    authors: Weiskirchen R,Weiskirchen S,Tacke F

    更新日期:2019-02-01 00:00:00

  • Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?

    abstract::ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes ...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.03.003

    authors: Galano JM,Roy J,Durand T,Lee JC,Le Guennec JY,Oger C,Demion M

    更新日期:2018-12-01 00:00:00

  • Endocannabinoids, exercise, pain, and a path to health with aging.

    abstract::Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid system (ECS) has emerged as a focal point to...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.10.001

    authors: Watkins BA

    更新日期:2018-12-01 00:00:00

  • Brain docosahexaenoic acid uptake and metabolism.

    abstract::Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2017.12.004

    authors: Lacombe RJS,Chouinard-Watkins R,Bazinet RP

    更新日期:2018-12-01 00:00:00

  • Omega-3 fatty acids and leukocyte-endothelium adhesion: Novel anti-atherosclerotic actions.

    abstract::Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.08.002

    authors: Baker EJ,Yusof MH,Yaqoob P,Miles EA,Calder PC

    更新日期:2018-12-01 00:00:00

  • Control of SUMO and Ubiquitin by ROS: Signaling and disease implications.

    abstract::Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversi...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.07.002

    authors: Stankovic-Valentin N,Melchior F

    更新日期:2018-10-01 00:00:00

  • Plant bioactives and redox signaling: (-)-Epicatechin as a paradigm.

    abstract::Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2018.01.007

    authors: Fraga CG,Oteiza PI,Galleano M

    更新日期:2018-06-01 00:00:00

  • Emerging role of extracellular vesicles in musculoskeletal diseases.

    abstract::Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2017.09.006

    authors: Murphy C,Withrow J,Hunter M,Liu Y,Tang YL,Fulzele S,Hamrick MW

    更新日期:2018-04-01 00:00:00

  • Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases.

    abstract::Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2017.11.005

    authors: Kadota T,Fujita Y,Yoshioka Y,Araya J,Kuwano K,Ochiya T

    更新日期:2018-04-01 00:00:00

  • Specialized pro-resolving mediators in cardiovascular diseases.

    abstract::The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2017.02.003

    authors: Fredman G,Spite M

    更新日期:2017-12-01 00:00:00

  • Insulin/adenosine axis linked signalling.

    abstract::Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2016.11.002

    authors: Silva L,Subiabre M,Araos J,Sáez T,Salsoso R,Pardo F,Leiva A,San Martín R,Toledo F,Sobrevia L

    更新日期:2017-06-01 00:00:00

  • Epigenetics in fibrosis.

    abstract::Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2016.10.001

    authors: O'Reilly S

    更新日期:2017-04-01 00:00:00

  • Folate status and colorectal cancer risk: A 2016 update.

    abstract::The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2016.11.010

    authors: Mason JB,Tang SY

    更新日期:2017-02-01 00:00:00

  • Regenerative decline of stem cells in sarcopenia.

    abstract::Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2016.02.002

    authors: Sousa-Victor P,Muñoz-Cánoves P

    更新日期:2016-08-01 00:00:00

  • Turning the headlights on novel cancer biomarkers: Inspection of mechanics underlying intratumor heterogeneity.

    abstract::Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2015.05.001

    authors: McBride M,Rida PC,Aneja R

    更新日期:2015-11-01 00:00:00

  • Mitochondrial regulation of β-cell function: maintaining the momentum for insulin release.

    abstract::All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2015.01.004

    authors: Kaufman BA,Li C,Soleimanpour SA

    更新日期:2015-04-01 00:00:00

  • Navigating the site for embryo implantation: biomechanical and molecular regulation of intrauterine embryo distribution.

    abstract::The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.07.017

    authors: Chen Q,Zhang Y,Elad D,Jaffa AJ,Cao Y,Ye X,Duan E

    更新日期:2013-10-01 00:00:00

  • Aging epigenetics: causes and consequences.

    abstract::Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on gen...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.06.006

    authors: Huidobro C,Fernandez AF,Fraga MF

    更新日期:2013-07-01 00:00:00

  • Cardiovascular epigenetics: from DNA methylation to microRNAs.

    abstract::Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.08.001

    authors: Udali S,Guarini P,Moruzzi S,Choi SW,Friso S

    更新日期:2013-07-01 00:00:00

  • The ABCs of membrane transporters in health and disease (SLC series): introduction.

    abstract::The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be foun...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.12.009

    authors: Hediger MA,Clémençon B,Burrier RE,Bruford EA

    更新日期:2013-04-01 00:00:00

  • Mammalian iron transporters: families SLC11 and SLC40.

    abstract::This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2. SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance a...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2013.01.002

    authors: Montalbetti N,Simonin A,Kovacs G,Hediger MA

    更新日期:2013-04-01 00:00:00

  • The SLCO (former SLC21) superfamily of transporters.

    abstract::The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.10.009

    authors: Hagenbuch B,Stieger B

    更新日期:2013-04-01 00:00:00

  • Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.

    abstract::About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.07.012

    authors: Schiöth HB,Roshanbin S,Hägglund MG,Fredriksson R

    更新日期:2013-04-01 00:00:00

  • Heme and FLVCR-related transporter families SLC48 and SLC49.

    abstract::Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.07.013

    authors: Khan AA,Quigley JG

    更新日期:2013-04-01 00:00:00

  • Obesity pharmacotherapy: what is next?

    abstract::The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.10.005

    authors: Colon-Gonzalez F,Kim GW,Lin JE,Valentino MA,Waldman SA

    更新日期:2013-02-01 00:00:00

  • Brain water channel proteins in health and disease.

    abstract::The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.03.008

    authors: Benga O,Huber VJ

    更新日期:2012-10-01 00:00:00

  • Nutritional modulation of age-related macular degeneration.

    abstract::Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.03.005

    authors: Weikel KA,Chiu CJ,Taylor A

    更新日期:2012-08-01 00:00:00

  • Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex.

    abstract::There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2012.04.005

    authors: Bhutto I,Lutty G

    更新日期:2012-08-01 00:00:00

  • Selenium and asthma.

    abstract::Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2011.10.003

    authors: Norton RL,Hoffmann PR

    更新日期:2012-02-01 00:00:00

  • Neuroprotective features of carnosine in oxidative driven diseases.

    abstract::Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues. Although its physiological role has not been completely understood yet, many beneficial actions have been attributed to carnosine, such as being an antioxidant, antiglycating and io...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2011.10.009

    authors: Bellia F,Vecchio G,Cuzzocrea S,Calabrese V,Rizzarelli E

    更新日期:2011-08-01 00:00:00

  • Growing tumor vessels: more than one way to skin a cat - implications for angiogenesis targeted cancer therapies.

    abstract::The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...

    journal_title:Molecular aspects of medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.mam.2011.04.001

    authors: Leite de Oliveira R,Hamm A,Mazzone M

    更新日期:2011-04-01 00:00:00

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