解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The Notch receptors are a family of transmembrane proteins that mediate direct cell-cell interactions and control numerous cell-fate specifications in humans. The extracellular domains of mammalian Notch proteins contain 29-36 tandem epidermal growth factor-like (EGF) repeats, most of which have O-linked glycan modifi...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/j.mam.2020.100938
更新日期:2020-12-16 00:00:00
abstract::Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/j.mam.2020.100923
更新日期:2020-11-04 00:00:00
abstract::Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity against tumors, different approaches have been developed for exploiting/harnessing their function in patients with leukemia or solid tumor...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2020.100870
更新日期:2020-08-13 00:00:00
abstract::In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2020.100871
更新日期:2020-07-20 00:00:00
abstract::Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immu...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.05.003
更新日期:2019-10-01 00:00:00
abstract::The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.05.002
更新日期:2019-10-01 00:00:00
abstract::Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.06.005
更新日期:2019-10-01 00:00:00
abstract::For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.07.001
更新日期:2019-08-01 00:00:00
abstract::The global prevalence of diabesity is on the rise, and the clinical, social and economic health burden arising from this epidemic is aggravated by a significant co-morbidity of diabesity with neuropsychiatric disease, particularly depression. Importantly, not only is the prevalence of mood disorders elevated in patien...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.11.003
更新日期:2019-04-01 00:00:00
abstract::Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process det...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.06.003
更新日期:2019-02-01 00:00:00
abstract::ω3 Polyunsaturated fatty acids (ω3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely ω3 PUFAs per se that are biologically active but the non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.03.003
更新日期:2018-12-01 00:00:00
abstract::Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid system (ECS) has emerged as a focal point to...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.10.001
更新日期:2018-12-01 00:00:00
abstract::Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.12.004
更新日期:2018-12-01 00:00:00
abstract::Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.08.002
更新日期:2018-12-01 00:00:00
abstract::Reversible post-translational modifications (PTMs) ensure rapid signal transmission from sensors to effectors. Reversible modification of proteins by the small proteins Ubiquitin and SUMO are involved in virtually all cellular processes and can modify thousands of proteins. Ubiquitination or SUMOylation is the reversi...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.07.002
更新日期:2018-10-01 00:00:00
abstract::Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.01.007
更新日期:2018-06-01 00:00:00
abstract::Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.09.006
更新日期:2018-04-01 00:00:00
abstract::Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular sene...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.11.005
更新日期:2018-04-01 00:00:00
abstract::The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.02.003
更新日期:2017-12-01 00:00:00
abstract::Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.11.002
更新日期:2017-06-01 00:00:00
abstract::Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.10.001
更新日期:2017-04-01 00:00:00
abstract::The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.11.010
更新日期:2017-02-01 00:00:00
abstract::Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.02.002
更新日期:2016-08-01 00:00:00
abstract::Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2015.05.001
更新日期:2015-11-01 00:00:00
abstract::All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2015.01.004
更新日期:2015-04-01 00:00:00
abstract::The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.017
更新日期:2013-10-01 00:00:00
abstract::Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on gen...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.06.006
更新日期:2013-07-01 00:00:00
abstract::Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.08.001
更新日期:2013-07-01 00:00:00
abstract::The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be foun...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.12.009
更新日期:2013-04-01 00:00:00
abstract::This review is focused on the mammalian SLC11 and SLC40 families and their roles in iron homeostasis. The SLC11 family is composed of two members, SLC11A1 and SLC11A2. SLC11A1 is expressed in the lysosomal compartment of macrophages and in the tertiary granules of neutrophils, playing a key role in innate resistance a...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2013.01.002
更新日期:2013-04-01 00:00:00
abstract::The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.10.009
更新日期:2013-04-01 00:00:00
abstract::About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.012
更新日期:2013-04-01 00:00:00
abstract::Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.013
更新日期:2013-04-01 00:00:00
abstract::The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.10.005
更新日期:2013-02-01 00:00:00
abstract::The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.03.008
更新日期:2012-10-01 00:00:00
abstract::Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.03.005
更新日期:2012-08-01 00:00:00
abstract::There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.04.005
更新日期:2012-08-01 00:00:00
abstract::Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.10.003
更新日期:2012-02-01 00:00:00
abstract::Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues. Although its physiological role has not been completely understood yet, many beneficial actions have been attributed to carnosine, such as being an antioxidant, antiglycating and io...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.10.009
更新日期:2011-08-01 00:00:00
abstract::The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.04.001
更新日期:2011-04-01 00:00:00