Abstract:
:For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting the so-called batokines to communicate with other metabolic tissues and regulate systemic energy homeostasis. However, despite numerous studies showing the benefits of BAT in rodents, it is still not clear whether recruitment of BAT can be utilized to treat human patients. Here, we review the advances on understanding the role of BAT in metabolism and its benefits on glucose and lipid homeostasis in both humans and rodents. Moreover, we discuss the latest methodological approaches to assess the contribution of BAT to human metabolism as well as the possibility to target BAT, pharmacologically or by lifestyle adaptations, to treat metabolic disorders.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Klepac K,Georgiadi A,Tschöp M,Herzig Sdoi
10.1016/j.mam.2019.07.001subject
Has Abstractpub_date
2019-08-01 00:00:00pages
90-100eissn
0098-2997issn
1872-9452pii
S0098-2997(19)30022-6journal_volume
68pub_type
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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journal_title:Molecular aspects of medicine
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