Abstract：
:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treatment, cardiovascular disease (CVD) remains a serious clinical problem and threat to public health. Resveratrol possesses potent antioxidant properties and has been shown to decrease low-density lipoprotein-cholesterol oxidation and platelet aggregation. This compound also possesses a range of additional cardioprotective and vasoprotective properties including antiatherosclerotic and vasorelaxation action. Resveratrol also has the capacity to interact with multiple molecular targets, which involve diverse intracellular pathways. Most well-known is the ability of resveratrol to activate sirtuins, a class of NAD(+)-dependent deacetylase that affect multiple transcription factors and other protein targets. Recently, resveratrol was found to induce autophagy and regenerate myocardial ischemic tissue treated with stem cells. Overall observation indicates that resveratrol has a high therapeutic potentials for the treatment of cardiovascular diseases.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Das M,Das DKdoi
10.1016/j.mam.2010.09.001subject
Has Abstractpub_date
2010-12-01 00:00:00pages
503-12issue
6eissn
0098-2997issn
1872-9452pii
S0098-2997(10)00070-1journal_volume
31pub_type
杂志文章,评审abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...
journal_title：Molecular aspects of medicine
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更新日期：2019-10-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/0098-2997(92)90006-l
更新日期：1992-01-01 00:00:00
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
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