Abstract：
:Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affecting membrane rheology. Aluminum-membrane interactions can also affect signaling cascades. Zinc, at high and low concentrations, increases cell oxidant concentrations, affects AP-1 and NF-kappaB transcription factors and induces neuronal cell death. The capacity of lead to promote oxidative stress, affect cell signals and to induce cell death by apoptosis has been mostly attributed to its effect on different calcium-mediated cellular events. The mentioned mechanisms as well as the contribution of these metals to different neurodegenerative disorders are discussed.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Oteiza PI,Mackenzie GG,Verstraeten SVdoi
10.1016/j.mam.2004.02.012keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
103-15issue
1-2eissn
0098-2997issn
1872-9452pii
S0098299704000135journal_volume
25pub_type
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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更新日期：1997-01-01 00:00:00
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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abstract：:Natural vitamin E consists of four different tocopherol and four different tocotrienol homologues (alpha,beta, gamma, delta) that all have antioxidant activity. However, recent data indicate that the different vitamin E homologues also have biological activity unrelated to their antioxidant activity. In this review, w...
journal_title：Molecular aspects of medicine
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abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...
journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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abstract：:Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...
journal_title：Molecular aspects of medicine
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doi：10.1016/j.mam.2017.09.006
更新日期：2018-04-01 00:00:00
