Molecular oncogenetics of metastasis.

abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...

journal_title：Molecular aspects of medicine

authors： Armeni T,Tomasetti M,Svegliati Baroni S,Saccucci F,Marra M,Pieri C,Littarru GP,Principato G,Battino M

更新日期：1997-01-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been frequently implicated in the initiation and promotion phases of carcinogenesis. Antioxidant enzymes, which can antagonize this process, are lowered in a number of malignancies. The enzyme most commonly decreased is the mitochondrial Mn-containing superoxide dismutase (MnSOD) enc...

journal_title：Molecular aspects of medicine

authors： Borrello S,De Leo ME,Galeotti T

更新日期：1993-01-01 00:00:00

abstract：:Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...

journal_title：Molecular aspects of medicine

authors： Khan AA,Quigley JG

更新日期：2013-04-01 00:00:00

abstract：:17Beta-estradiol (E2) controls many aspects of human physiology, including development, reproduction and homeostasis, through regulation of the transcriptional activity of its cognate receptors (ERs). The crystal structures of ERs with agonists and antagonists and the use of transgenic animals have revealed much about...

journal_title：Molecular aspects of medicine

authors： Ascenzi P,Bocedi A,Marino M

更新日期：2006-08-01 00:00:00

abstract：:There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...

journal_title：Molecular aspects of medicine

authors： Bhutto I,Lutty G

更新日期：2012-08-01 00:00:00

abstract：:RNA interference (RNAi) has emerged as one of the most important discoveries of the last years in the field of molecular biology. Following clarification of this highly conserved endogenous gene silencing mechanism, RNAi has largely been exploited as a powerful tool to uncover the function of specific genes and to und...

journal_title：Molecular aspects of medicine

authors： Masiero M,Nardo G,Indraccolo S,Favaro E

更新日期：2007-02-01 00:00:00

abstract：:L-Carnitine (L-C) is a naturally occurring quaternary ammonium compound endogenous in all mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty ...

journal_title：Molecular aspects of medicine

authors： Virmani A,Binienda Z

更新日期：2004-10-01 00:00:00

abstract：:Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process det...

journal_title：Molecular aspects of medicine

authors： Weiskirchen R,Weiskirchen S,Tacke F

更新日期：2019-02-01 00:00:00

abstract：:Angiogenesis is integral to the growth and metastatic spread of tumours, and its targeting is an effective anti-tumour strategy. Currently hundreds of anti-angiogenic therapeutics exist in varying stages of development, a number of which have recently gained US Food and Drug Administration (FDA) approval for the treat...

journal_title：Molecular aspects of medicine

authors： Park D,Dilda PJ

更新日期：2010-02-01 00:00:00

abstract：:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avast...

journal_title：Molecular aspects of medicine

authors： Waldner MJ,Neurath MF

更新日期：2010-04-01 00:00:00

abstract：:The aldehyde 4-hydroxynonenal (HNE) is a major end-product of peroxidation of membrane n-6-polyunsaturated fatty acids. Primary reactants for HNE are the amino acids cysteine, histidine and lysine, and quantitatively, proteins and peptides represent the most important group of HNE-targeted biomolecules. HNE-protein ad...

journal_title：Molecular aspects of medicine

authors： Poli G,Biasi F,Leonarduzzi G

更新日期：2008-02-01 00:00:00

abstract：:Reduced glutathione (GSH) is critical for many cellular processes, and both its intracellular and extracellular concentrations are tightly regulated. Intracellular GSH levels are regulated by two main mechanisms: by adjusting the rates of synthesis and of export from cells. Some of the proteins responsible for GSH exp...

journal_title：Molecular aspects of medicine

authors： Ballatori N,Krance SM,Marchan R,Hammond CL

更新日期：2009-02-01 00:00:00

abstract：:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...

journal_title：Molecular aspects of medicine

authors： Das M,Das DK

更新日期：2010-12-01 00:00:00

abstract：:Fibrosis is a common and important disease. It is a pathological state due to excessive scar formation mediated by an increase in activated fibroblasts that express alpha smooth muscle actin and copious amounts of extracellular matrix molecules. Epigenetics is an area of research that encompasses three main mechanisms...

journal_title：Molecular aspects of medicine

authors： O'Reilly S

更新日期：2017-04-01 00:00:00

abstract：:Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...

journal_title：Molecular aspects of medicine

authors： Udali S,Guarini P,Moruzzi S,Choi SW,Friso S

更新日期：2013-07-01 00:00:00

abstract：:Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Oteiza PI,Galleano M

更新日期：2018-06-01 00:00:00

abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Galleano M,Verstraeten SV,Oteiza PI

更新日期：2010-12-01 00:00:00

abstract：:The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...

journal_title：Molecular aspects of medicine

authors： Van Prooyen N,Andresen V,Gold H,Bialuk I,Pise-Masison C,Franchini G

更新日期：2010-10-01 00:00:00

abstract：:Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...

journal_title：Molecular aspects of medicine

authors： Hajishengallis G,Li X,Chavakis T

更新日期：2020-11-04 00:00:00

abstract：:Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...

journal_title：Molecular aspects of medicine

authors： Keaney JF Jr

更新日期：2000-08-01 00:00:00

abstract：:In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...

journal_title：Molecular aspects of medicine

authors： Altinoz MA,Elmaci İ,Hacimuftuoglu A,Ozpinar A,Hacker E,Ozpinar A

更新日期：2020-07-20 00:00:00

abstract：:All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the metabolism of exogenous nutrients into energy output, which ultimately leads to insulin release. As such, mitochondrial dysfunction un...

journal_title：Molecular aspects of medicine

authors： Kaufman BA,Li C,Soleimanpour SA

更新日期：2015-04-01 00:00:00

abstract：:Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on gen...

journal_title：Molecular aspects of medicine

authors： Huidobro C,Fernandez AF,Fraga MF

更新日期：2013-07-01 00:00:00

abstract：:The aim of this article is to describe the roles of water channel proteins (WCPs) in brain functionality. The fluid compartments of the brain, which include the brain parenchyma (with intracellular and extracellular spaces), the intravascular and the cerebrospinal fluid compartments are presented. Then the localizatio...

journal_title：Molecular aspects of medicine

authors： Benga O,Huber VJ

更新日期：2012-10-01 00:00:00

abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...

journal_title：Molecular aspects of medicine

authors： Catalano MG,Poli R,Pugliese M,Fortunati N,Boccuzzi G

更新日期：2010-04-01 00:00:00

abstract：:Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...

journal_title：Molecular aspects of medicine

authors： Baker EJ,Yusof MH,Yaqoob P,Miles EA,Calder PC

更新日期：2018-12-01 00:00:00

abstract：:Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...

journal_title：Molecular aspects of medicine

authors： McBride M,Rida PC,Aneja R

更新日期：2015-11-01 00:00:00

abstract：:Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues. Although its physiological role has not been completely understood yet, many beneficial actions have been attributed to carnosine, such as being an antioxidant, antiglycating and io...

journal_title：Molecular aspects of medicine

authors： Bellia F,Vecchio G,Cuzzocrea S,Calabrese V,Rizzarelli E

更新日期：2011-08-01 00:00:00

abstract：:Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...

journal_title：Molecular aspects of medicine

authors： Silva L,Subiabre M,Araos J,Sáez T,Salsoso R,Pardo F,Leiva A,San Martín R,Toledo F,Sobrevia L

更新日期：2017-06-01 00:00:00

abstract：:The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...

journal_title：Molecular aspects of medicine

authors： Chen Q,Zhang Y,Elad D,Jaffa AJ,Cao Y,Ye X,Duan E

更新日期：2013-10-01 00:00:00