Brain water channel proteins in health and disease.

abstract：:The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be foun...

journal_title：Molecular aspects of medicine

authors： Hediger MA,Clémençon B,Burrier RE,Bruford EA

更新日期：2013-04-01 00:00:00

abstract：:The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...

journal_title：Molecular aspects of medicine

authors： Mason JB,Tang SY

更新日期：2017-02-01 00:00:00

abstract：:Angiogenesis is integral to the growth and metastatic spread of tumours, and its targeting is an effective anti-tumour strategy. Currently hundreds of anti-angiogenic therapeutics exist in varying stages of development, a number of which have recently gained US Food and Drug Administration (FDA) approval for the treat...

journal_title：Molecular aspects of medicine

authors： Park D,Dilda PJ

更新日期：2010-02-01 00:00:00

abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...

journal_title：Molecular aspects of medicine

authors： Weber C,Jakobsen TS,Mortensen SA,Paulsen G,Hølmer G

更新日期：1994-01-01 00:00:00

abstract：:Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host inflammatory cells followed by inhibition of tumor growth. This local effect is often accompanied by systemic protection mediated by the immune system, mainly by CD8(+) T and NK cells. On this basis, cytokine gene-transd...

journal_title：Molecular aspects of medicine

authors： Minuzzo S,Moserle L,Indraccolo S,Amadori A

更新日期：2007-02-01 00:00:00

abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Galleano M,Verstraeten SV,Oteiza PI

更新日期：2010-12-01 00:00:00

abstract：:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...

journal_title：Molecular aspects of medicine

authors： Bargossi AM,Grossi G,Fiorella PL,Gaddi A,Di Giulio R,Battino M

更新日期：1994-01-01 00:00:00

abstract：:L-Carnitine (L-C) is a naturally occurring quaternary ammonium compound endogenous in all mammalian species and is a vital cofactor for the mitochondrial oxidation of fatty acids. Fatty acids are utilized as an energy substrate in all tissues, and although glucose is the main energetic substrate in adult brain, fatty ...

journal_title：Molecular aspects of medicine

authors： Virmani A,Binienda Z

更新日期：2004-10-01 00:00:00

abstract：:The aldehyde 4-hydroxynonenal (HNE) is a major end-product of peroxidation of membrane n-6-polyunsaturated fatty acids. Primary reactants for HNE are the amino acids cysteine, histidine and lysine, and quantitatively, proteins and peptides represent the most important group of HNE-targeted biomolecules. HNE-protein ad...

journal_title：Molecular aspects of medicine

authors： Poli G,Biasi F,Leonarduzzi G

更新日期：2008-02-01 00:00:00

abstract：:Although colorectal cancer (CRC) is still one of the leading causes of cancer related death in the western hemisphere, new therapeutic options have increased the overall survival rate of advanced disease from 10 to 18-24months during the past decade. The new therapeutics include biological agents as bevacizumab (Avast...

journal_title：Molecular aspects of medicine

authors： Waldner MJ,Neurath MF

更新日期：2010-04-01 00:00:00

abstract：:There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrop...

journal_title：Molecular aspects of medicine

authors： Bhutto I,Lutty G

更新日期：2012-08-01 00:00:00

abstract：:Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...

journal_title：Molecular aspects of medicine

authors： Silva L,Subiabre M,Araos J,Sáez T,Salsoso R,Pardo F,Leiva A,San Martín R,Toledo F,Sobrevia L

更新日期：2017-06-01 00:00:00

abstract：:Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particul...

journal_title：Molecular aspects of medicine

authors： Murphy N,Moreno V,Hughes DJ,Vodicka L,Vodicka P,Aglago EK,Gunter MJ,Jenab M

更新日期：2019-10-01 00:00:00

abstract：:Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to injury in many tissues. Although the extracellular matrix deposition appears unstructured disrupting the normal tissue architecture and subsequently impairing proper organ function, fibrogenesis is a highly orchestrated process det...

journal_title：Molecular aspects of medicine

authors： Weiskirchen R,Weiskirchen S,Tacke F

更新日期：2019-02-01 00:00:00

abstract：:When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane st...

journal_title：Molecular aspects of medicine

authors： Monastyrska I,Klionsky DJ

更新日期：2006-10-01 00:00:00

abstract：:Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...

journal_title：Molecular aspects of medicine

authors： Keaney JF Jr

更新日期：2000-08-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the brain where it serves to regulate several important processes and, in addition, serves as a precursor to bioactive mediators. Given that the capacity of the brain to synthesize DHA locally is appreciably low, the uptake of DHA from c...

journal_title：Molecular aspects of medicine

authors： Lacombe RJS,Chouinard-Watkins R,Bazinet RP

更新日期：2018-12-01 00:00:00

abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...

journal_title：Molecular aspects of medicine

authors： Folkers K,Moesgaard S,Morita M

更新日期：1994-01-01 00:00:00

abstract：:In this mini review we summarize recent studies from our laboratory, which show the involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and caspase-3 activation. Cells exposed to mild, transient, heat ...

journal_title：Molecular aspects of medicine

authors： Awasthi YC,Sharma R,Cheng JZ,Yang Y,Sharma A,Singhal SS,Awasthi S

更新日期：2003-08-01 00:00:00

abstract：:Carnosine and related dipeptides such as anserine are naturally-occurring histidine-containing compounds. They are found in several tissues most notably in muscle where they represent an appreciable fraction of the total water-soluble nitrogen-containing compounds. The biological role of these dipeptides are conjectur...

journal_title：Molecular aspects of medicine

authors： Quinn PJ,Boldyrev AA,Formazuyk VE

更新日期：1992-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...

journal_title：Molecular aspects of medicine

authors： Weikel KA,Chiu CJ,Taylor A

更新日期：2012-08-01 00:00:00

abstract：:Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...

journal_title：Molecular aspects of medicine

authors： Baker EJ,Yusof MH,Yaqoob P,Miles EA,Calder PC

更新日期：2018-12-01 00:00:00

abstract：:Skeletal muscle mass and function decline with aging, a process known as sarcopenia, which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is also linked to a progressive reduction in the regenerative capacity of the skeletal muscle stem cells (satellite cells), which are critica...

journal_title：Molecular aspects of medicine

authors： Sousa-Victor P,Muñoz-Cánoves P

更新日期：2016-08-01 00:00:00

abstract：:Physical activity is an important lifestyle factor for growth, development, and sustained health throughout life. In recent years, the benefits of physical activity have drawn more attention to its physiological effects on the body, including well-being. The endocannabinoid system (ECS) has emerged as a focal point to...

journal_title：Molecular aspects of medicine

authors： Watkins BA

更新日期：2018-12-01 00:00:00

abstract：:Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...

journal_title：Molecular aspects of medicine

authors： McBride M,Rida PC,Aneja R

更新日期：2015-11-01 00:00:00

abstract：:Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...

journal_title：Molecular aspects of medicine

authors： Armeni T,Tomasetti M,Svegliati Baroni S,Saccucci F,Marra M,Pieri C,Littarru GP,Principato G,Battino M

更新日期：1997-01-01 00:00:00

abstract：:The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...

journal_title：Molecular aspects of medicine

authors： Grolleman JE,Díaz-Gay M,Franch-Expósito S,Castellví-Bel S,de Voer RM

更新日期：2019-10-01 00:00:00

abstract：:The establishment of a functional, integrated vascular system is instrumental for tissue growth and homeostasis. Without blood vessels no adequate nutrition and oxygen would be provided to cells, nor could the undesired waste products be efficiently removed. Blood vessels constitute therefore one of the largest and mo...

journal_title：Molecular aspects of medicine

authors： Leite de Oliveira R,Hamm A,Mazzone M

更新日期：2011-04-01 00:00:00

abstract：:The vitamin D endocrine system plays a central role in mineral ion homeostasis through the actions of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], on the intestine, bone, parathyroid gland, and kidney. The main function of 1,25(OH)(2)D(3) is to promote the dietary absorption of calcium and phos...

journal_title：Molecular aspects of medicine

authors： Brown AJ,Slatopolsky E

更新日期：2008-12-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...

journal_title：Molecular aspects of medicine

authors： Sinatra ST

更新日期：1997-01-01 00:00:00