Abstract：
:Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is essential for demand-adapted hematopoiesis. Also of critical importance for HSC function, specific metabolic cues (e.g., associated with changes in energy or O2 levels) can regulate HSC function and fate decisions. In this regard, the metabolic adaptation of HSCs facilitates their switching between different states, namely quiescence, self-renewal, proliferation and differentiation. Specific metabolic alterations in hematopoietic stem and progenitor cells (HSPCs) have been linked with the induction of trained myelopoiesis in the bone marrow as well as with HSPC dysfunction in aging and clonal hematopoiesis of indeterminate potential (CHIP). Thus, HSPC function is regulated by both immunologic/inflammatory and metabolic cues. The immunometabolic control of HSPCs and of hematopoiesis is discussed in this review along with the translational implications thereof, that is, how metabolic pathways can be therapeutically manipulated to prevent or reverse HSPC dysfunction or to enhance or attenuate trained myelopoiesis according to the needs of the host.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Hajishengallis G,Li X,Chavakis Tdoi
10.1016/j.mam.2020.100923subject
Has Abstractpub_date
2020-11-04 00:00:00pages
100923eissn
0098-2997issn
1872-9452pii
S0098-2997(20)30125-4pub_type
杂志文章abstract：:The distribution of intrauterine embryo implantation site(s) in most mammalian species shows remarkably constant patterns: in monotocous species such as humans, an embryo tends to implant in the uterine fundus; in polytocous species such as rodents, embryos implant evenly along the uterine horns. These long-time evolv...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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abstract：:Hepatitis C virus (HCV) infection is a global health problem, being the second most common chronic viral infection in the world with a global prevalence of about 3% (about 180 million people). HCV is both an hepatotropic and a lymphotropic virus; and chronic infection could cause, on one hand, chronic hepatitis, cirrh...
journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2007-10-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
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更新日期：2010-04-01 00:00:00
