Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis.

abstract：:When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane st...

journal_title：Molecular aspects of medicine

authors： Monastyrska I,Klionsky DJ

更新日期：2006-10-01 00:00:00

abstract：:Peroxisomes were long believed to play only a minor role in cellular metabolism but it is now clear that they catalyze a number of important functions. The importance of peroxisomes in humans is stressed by the existence of a group of genetic diseases in man in which one or more peroxisomal functions are impaired. Mos...

journal_title：Molecular aspects of medicine

authors： Wanders RJ,Tager JM

更新日期：1998-04-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30-50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries (Gehrs et al., 2006). Costs associated with AMD are in exces...

journal_title：Molecular aspects of medicine

authors： Weikel KA,Chiu CJ,Taylor A

更新日期：2012-08-01 00:00:00

abstract：:The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...

journal_title：Molecular aspects of medicine

authors： Grolleman JE,Díaz-Gay M,Franch-Expósito S,Castellví-Bel S,de Voer RM

更新日期：2019-10-01 00:00:00

abstract：:A human study including 22 volunteers was conducted to investigate the antioxidative effect in blood of dietary coenzyme Q10 supplementation. The levels of alpha-tocopherol, ascorbic acid, lipid peroxidation (measured as TBARS) and the redox status of CoQ10 (reduced CoQ10/total CoQ10) were measured in plasma as marker...

journal_title：Molecular aspects of medicine

authors： Weber C,Jakobsen TS,Mortensen SA,Paulsen G,Hølmer G

更新日期：1994-01-01 00:00:00

abstract：:Se is a potent nutritional antioxidant important for various aspects of human health. Because asthma has been demonstrated to involve increased oxidative stress, levels of Se intake have been hypothesized to play an important role in the pathogenesis of asthma. However, significant associations between Se status and p...

journal_title：Molecular aspects of medicine

authors： Norton RL,Hoffmann PR

更新日期：2012-02-01 00:00:00

abstract：:Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on gen...

journal_title：Molecular aspects of medicine

authors： Huidobro C,Fernandez AF,Fraga MF

更新日期：2013-07-01 00:00:00

abstract：:Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...

journal_title：Molecular aspects of medicine

authors： Oteiza PI,Mackenzie GG,Verstraeten SV

更新日期：2004-02-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...

journal_title：Molecular aspects of medicine

authors： Sinatra ST

更新日期：1997-01-01 00:00:00

abstract：:The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be foun...

journal_title：Molecular aspects of medicine

authors： Hediger MA,Clémençon B,Burrier RE,Bruford EA

更新日期：2013-04-01 00:00:00

abstract：:Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...

journal_title：Molecular aspects of medicine

authors： Folkers K,Moesgaard S,Morita M

更新日期：1994-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSC) lie at the center of the hematopoiesis process, as they bear capacity to self-renew and generate all hematopoietic lineages, hence, all mature blood cells. The ability of HSCs to recognize systemic infection or inflammation or other forms of peripheral stress, such as blood loss, is esse...

journal_title：Molecular aspects of medicine

authors： Hajishengallis G,Li X,Chavakis T

更新日期：2020-11-04 00:00:00

abstract：:Although the existence of intratumoral heterogeneity (ITH) in the expression of common biomarkers has been described by pathologists since the late 1890s, we have only recently begun to fathom the staggering extent and near ubiquity of this phenomenon. From the tumor's perspective, ITH provides a stabilizing diversity...

journal_title：Molecular aspects of medicine

authors： McBride M,Rida PC,Aneja R

更新日期：2015-11-01 00:00:00

abstract：:The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of pro-inflammatory mediators, diminish the recru...

journal_title：Molecular aspects of medicine

authors： Fredman G,Spite M

更新日期：2017-12-01 00:00:00

abstract：:The consensus of epidemiologic evidence indicates that an abundant intake of foodstuffs rich in folate conveys protection against the development of colorectal cancer, and perhaps some other common cancers as well. Pre-clinical models substantiate that the relationship is a genuinely causal one. Pre-clinical models ha...

journal_title：Molecular aspects of medicine

authors： Mason JB,Tang SY

更新日期：2017-02-01 00:00:00

abstract：:Polyphenols are bioactives claimed to be responsible for some of the health benefits provided by fruit and vegetables. It is currently accepted that the bioactivities of polyphenols can be mostly ascribed to their interactions with proteins and lipids. Such interactions can affect cell oxidant production and cell sign...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Oteiza PI,Galleano M

更新日期：2018-06-01 00:00:00

abstract：:Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings...

journal_title：Molecular aspects of medicine

authors： Suzuki Y,Taniyama M,Muramatsu T,Atsumi Y,Hosokawa K,Asahina T,Shimada A,Murata C,Matsuoka K

更新日期：1997-01-01 00:00:00

abstract：:Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...

journal_title：Molecular aspects of medicine

authors： Winklhofer-Roob BM,Rock E,Ribalta J,Shmerling DH,Roob JM

更新日期：2003-12-01 00:00:00

abstract：:Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...

journal_title：Molecular aspects of medicine

authors： Murphy C,Withrow J,Hunter M,Liu Y,Tang YL,Fulzele S,Hamrick MW

更新日期：2018-04-01 00:00:00

abstract：:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood level...

journal_title：Molecular aspects of medicine

authors： Bargossi AM,Grossi G,Fiorella PL,Gaddi A,Di Giulio R,Battino M

更新日期：1994-01-01 00:00:00

abstract：:Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibilit...

journal_title：Molecular aspects of medicine

authors： Fraga CG,Galleano M,Verstraeten SV,Oteiza PI

更新日期：2010-12-01 00:00:00

abstract：:Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional therapies and do not respond to radioiodine and comprises metastatic or recurrent differentiated cancers, poorly differentiated and anaplastic tumors. Progress in the knowledge of genetic/epigenetic alterations in thyroid cancer cells...

journal_title：Molecular aspects of medicine

authors： Catalano MG,Poli R,Pugliese M,Fortunati N,Boccuzzi G

更新日期：2010-04-01 00:00:00

abstract：:Coenzyme Q is uniquely designed as an electron and proton carrier within the lipid phase of membranes. It now appears that this unique chemistry has diverse application to important functions in all cellular membranes. The first function of coenzyme Q was defined in the energy transduction process in mitochondria. New...

journal_title：Molecular aspects of medicine

authors： Crane FL,Navas P

更新日期：1997-01-01 00:00:00

abstract：:For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...

journal_title：Molecular aspects of medicine

authors： Klepac K,Georgiadi A,Tschöp M,Herzig S

更新日期：2019-08-01 00:00:00

abstract：:Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...

journal_title：Molecular aspects of medicine

authors： Das M,Das DK

更新日期：2010-12-01 00:00:00

abstract：:Delivery of cytokine genes at the tumor site in pre-clinical models has been shown to recruit host inflammatory cells followed by inhibition of tumor growth. This local effect is often accompanied by systemic protection mediated by the immune system, mainly by CD8(+) T and NK cells. On this basis, cytokine gene-transd...

journal_title：Molecular aspects of medicine

authors： Minuzzo S,Moserle L,Indraccolo S,Amadori A

更新日期：2007-02-01 00:00:00

abstract：:In this review study, we focus on potential benefits of the transcription factor PPARδ and its ligand erucic acid (EA) in management of neuroectodermal tumors and Parkinson's Disease. PPARδ is a nuclear receptor and transcription factor that induces myelination, promotes oligodendroglial and neuronal differentiation, ...

journal_title：Molecular aspects of medicine

authors： Altinoz MA,Elmaci İ,Hacimuftuoglu A,Ozpinar A,Hacker E,Ozpinar A

更新日期：2020-07-20 00:00:00

abstract：:Metastasis is a complex non-stochastic process that is most likely the result of genetic and epigenetic interactions of a wide variety of genes. The search for a single gene which can encompass such a pleiotropic response as to account for the observed phenotypic characteristics of metastatic tumour populations has be...

journal_title：Molecular aspects of medicine

authors： Dear TN,Kefford RF

更新日期：1990-01-01 00:00:00

abstract：:The increase in obesity in the Unites States and around the world in the last decade is overwhelming. The number of overweight adults in the world surpassed 1 billion in 2008. Health hazards associated with obesity are serious and include heart disease, sleep apnea, diabetes, and cancer. Although lifestyle modificatio...

journal_title：Molecular aspects of medicine

authors： Colon-Gonzalez F,Kim GW,Lin JE,Valentino MA,Waldman SA

更新日期：2013-02-01 00:00:00

abstract：:The Notch receptors are a family of transmembrane proteins that mediate direct cell-cell interactions and control numerous cell-fate specifications in humans. The extracellular domains of mammalian Notch proteins contain 29-36 tandem epidermal growth factor-like (EGF) repeats, most of which have O-linked glycan modifi...

journal_title：Molecular aspects of medicine

authors： Matsumoto K,Luther KB,Haltiwanger RS

更新日期：2020-12-16 00:00:00