Abstract：
:The biosynthetic pathway of the CoQ polyisoprenoid side chain, starting from acetyl-CoA and proceeding through mevalonate and isopentenylpyrophosphate, is the same as that of cholesterol. We performed this study to evaluate whether vastatins (hypocholesterolemic drugs that inhibit HMG-CoA reductase) modify blood levels of ubiquinone. Thirty-four unrelated outpatients with hypercholesterolemia (IIa phenotype) were treated with 20 mg of simvastatin for a 6-month period (group S) or with 20 mg of simvastatin plus 100 mg CoQ10 (group US). The following parameters were evaluated at time 0, 45, 90, 135 and 180 days: total plasma cholesterol (TC), HDL-cholesterol, LDL-cholesterol (LDL-C), triglycerides (TG), apo A1, apo B and CoQ10 in plasma and platelets. In the S group, there was a marked decrease in TC and LDL-C (from 290.3 mg/dl to 228.7 mg/dl for TC and from 228.7 mg/dl to 167.6 mg/dl for LDL-C) and in plasma CoQ10 levels from 1.08 mg/dl to 0.80 mg/dl. In contrast, in the US group we observed a significant increase of CoQ10 in plasma (from 1.20 to 1.48 mg/dl) while the hypocholesterolemic effect was similar to that observed in the S group. Platelet CoQ10 also decreased in the S group (from 104 to 90 ng/mg) and increased in the US group (from 95 to 145 ng/mg). This study demonstrates that simvastatin lowers both LDL-C and apo B plasma levels together with the plasma and platelet levels of CoQ10, and that CoQ10 therapy prevents both plasma and platelet CoQ10 decrease, without affecting the cholesterol lowering effect of simvastatin.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
Bargossi AM,Grossi G,Fiorella PL,Gaddi A,Di Giulio R,Battino Mdoi
10.1016/0098-2997(94)90028-0subject
Has Abstractpub_date
1994-01-01 00:00:00pages
s187-93eissn
0098-2997issn
1872-9452pii
0098-2997(94)90028-0journal_volume
15 Supplpub_type
临床试验,杂志文章,随机对照试验abstract：:Endothelial cells (ECs) play a role in the optimal function of blood vessels. When endothelial function becomes dysregulated, the risk of developing atherosclerosis increases. Specifically, upregulation of adhesion molecule expression on ECs promotes the movement of leukocytes, particularly monocytes, into the vessel ...
journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2006.12.004
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2018-12-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2008.06.001
更新日期：2008-10-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.08.001
更新日期：2013-07-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/s0098-2997(03)00017-7
更新日期：2003-08-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2013-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-08-13 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：1998-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章
doi：10.1016/0098-2997(93)90012-3
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2012.10.005
更新日期：2013-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2010.02.005
更新日期：2010-04-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2012-08-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
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更新日期：2019-02-01 00:00:00
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journal_title：Molecular aspects of medicine
pub_type： 杂志文章,评审
doi：10.1016/j.mam.2016.02.002
更新日期：2016-08-01 00:00:00
