Abstract:
:Colorectal cancer can be categorized into two major molecular subtypes according to the status of their DNA proofreading and repair machinery. The DNA repair status of tumor cells plays a major role in shaping the immune landscape of tumors and in determining the clinical response of colorectal cancer patients to immune checkpoint blockade therapies. Colorectal cancers that develop in a context of DNA mismatch repair or polymerase proofreading deficiency are generally conspicuously infiltrated by effector memory T cells and are associated with an improved clinical prognosis relative to their replication repair-proficient counterpart. While mismatch repair-deficient colorectal cancers, and most likely POLE and POLD1-mutated cancers, are amenable to immune checkpoint blockade therapies, the promise of immunotherapy still remains unfulfilled for for the majority of colorectal cancer patients. This review focusses on the role of the immune system in the tumorigenesis and clinical behavior of colorectal cancer. Furthermore, we discuss how latest advances in the fields of genomics and oncoimmunology may pave the way to broaden the scope of immunotherapy for this disease.
journal_name
Mol Aspects Medjournal_title
Molecular aspects of medicineauthors
IJsselsteijn ME,Sanz-Pamplona R,Hermitte F,de Miranda NFCCdoi
10.1016/j.mam.2019.05.003subject
Has Abstractpub_date
2019-10-01 00:00:00pages
123-129eissn
0098-2997issn
1872-9452pii
S0098-2997(19)30036-6journal_volume
69pub_type
杂志文章,评审abstract::Heme is critical for a variety of cellular processes, but excess intracellular heme may result in oxidative stress and membrane injury. Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic i...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.013
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abstract::The members of the organic anion transporting polypeptide superfamily (OATPs) are classified within the SLCO solute carrier family. All functionally well characterized members are predicted to have 12 transmembrane domains and are sodium-independent transport systems that mediate the transport of a broad range of endo...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
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abstract::For the past decade, brown adipose tissue (BAT) has been extensively studied as a potential therapy for obesity and metabolic diseases due to its thermogenic and glucose-consuming properties. It is now clear that the function of BAT goes beyond heat production, as it also plays an important endocrine role by secreting...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.07.001
更新日期:2019-08-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2015.05.001
更新日期:2015-11-01 00:00:00
abstract::Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by ag...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/s0098-2997(97)00021-6
更新日期:1997-01-01 00:00:00
abstract::Resveratrol (3,4',5-trihydroxystilbene) is a member of natural, plant-derived chemicals known as polyphenols and is attracting increased attention due to its diverse health benefits especially in case of cardiovascular disease, cancer, diabetes and neurological problems. Despite impressive gains in diagnosis and treat...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2010.09.001
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.10.003
更新日期:2012-02-01 00:00:00
abstract::Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coen...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/0098-2997(94)90039-6
更新日期:1994-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(03)00017-7
更新日期:2003-08-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2011.04.001
更新日期:2011-04-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.10.005
更新日期:2013-02-01 00:00:00
abstract::Vitamin E and carotenoids are known to act as antioxidants both in vitro and in vivo. In this review we present a series of studies in healthy subjects and in patients who exhibit either acute or chronic oxidative stress. In the EU-Commission funded VITAGE project we investigated the status and effects of vitamin E an...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(03)00035-9
更新日期:2003-12-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.04.005
更新日期:2012-08-01 00:00:00
abstract::Regulation of blood flow depends on systemic and local release of vasoactive molecules such as insulin and adenosine. These molecules cause vasodilation by activation of plasma membrane receptors at the vascular endothelium. Adenosine activates at least four subtypes of adenosine receptors (A1AR, A2AAR, A2BAR, A3AR), ...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2016.11.002
更新日期:2017-06-01 00:00:00
abstract::Peroxisomes were long believed to play only a minor role in cellular metabolism but it is now clear that they catalyze a number of important functions. The importance of peroxisomes in humans is stressed by the existence of a group of genetic diseases in man in which one or more peroxisomal functions are impaired. Mos...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(98)00003-x
更新日期:1998-04-01 00:00:00
abstract::The somatic mutation spectrum imprinted in the genome of a tumor represents the mutational processes that have been active in that tumor. Large sequencing efforts in various cancer types have resulted in the identification of multiple mutational signatures, of which several have been linked to specific biological mech...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2019.05.002
更新日期:2019-10-01 00:00:00
abstract::The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular gene expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2010.07.001
更新日期:2010-10-01 00:00:00
abstract::Diabetes mellitus associated with mitochondrial tRNA mutation at position 3243(DM-Mt3243) is a new disease. Patients have a distinctly different picture from MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). During observations at the Saiseikai Central Hospital, the following findings...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(97)00041-1
更新日期:1997-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/0098-2997(93)90012-3
更新日期:1993-01-01 00:00:00
abstract::The vitamin D endocrine system plays a central role in mineral ion homeostasis through the actions of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], on the intestine, bone, parathyroid gland, and kidney. The main function of 1,25(OH)(2)D(3) is to promote the dietary absorption of calcium and phos...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2008.04.001
更新日期:2008-12-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.07.001
更新日期:2006-08-01 00:00:00
abstract::Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2017.09.006
更新日期:2018-04-01 00:00:00
abstract::Epigenetic phenomena are defined as heritable mechanisms that establish and maintain mitotically stable patterns of gene expression without modifying the base sequence of DNA. The major epigenetic features of mammalian cells include DNA methylation, post-translational histone modifications and RNA-based mechanisms inc...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.08.001
更新日期:2013-07-01 00:00:00
abstract::Coenzyme Q10 (CoQ10) is a critical adjuvant therapy for patients with congestive heart failure (CHF), even when traditional medical therapy is successful. Adjunctive therapy with Q10 may allow for a reduction of other pharmacological therapies, improvement in quality of life, and a decrease in the incidence of cardiac...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章
doi:10.1016/s0098-2997(97)00011-3
更新日期:1997-01-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2006.08.004
更新日期:2006-10-01 00:00:00
abstract::About 25% of all solute carriers (SLCs) are likely to transport amino acids as their primary substrate. One of the major phylogenetic clusters of amino acid transporters from the SLC family is the β-family, which is part of the PFAM APC clan. The β-family includes three SLC families, SLC32, SLC36 and SLC38 with one, f...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2012.07.012
更新日期:2013-04-01 00:00:00
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journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2018.06.003
更新日期:2019-02-01 00:00:00
abstract::Oxidant-mediated damage and the triggering of oxidant-sensitive transcription factors could be associated with the neurotoxic actions of aluminum, zinc and lead. Aluminum and lead could induce oxidative stress through their capacity to interact with active oxygen species, increasing their oxidant activity, or by affec...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/j.mam.2004.02.012
更新日期:2004-02-01 00:00:00
abstract::Atherosclerosis is an important source of morbidity and mortality in the developed world. Despite the fact that the association between LDL cholesterol and atherosclerosis has been evident for at least three decades, our understanding of exactly how LDL precipitates atherosclerosis is still in its infancy. At least th...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(00)00005-4
更新日期:2000-08-01 00:00:00
abstract::The oxidation of low density lipoprotein (LDL) is now commonly regarded as an important early event in atherogenesis. As such there is considerable interest in the ability of antioxidant supplementation to attenuate LDL oxidation and hence atherosclerosis. A majority of studies on LDL antioxidation have focused on alp...
journal_title:Molecular aspects of medicine
pub_type: 杂志文章,评审
doi:10.1016/s0098-2997(97)00031-9
更新日期:1997-01-01 00:00:00