Abstract：
OBJECTIVE:This systematic literature review sought to determine the effects of carotid atherosclerotic plaque on local arterial stiffness. METHODS:MedLine, EMBASE, and grey literature were searched with the following term: ("atherosclerosis" or "carotid atherosclerosis" or "carotid artery disease" or "carotid plaque") AND ("distensibility" or "elasticity" or "stiffness" or "compliance") NOT ("pulse wave velocity" or "PWV" or "carotid-ankle" or "ankle-brachial" or "augmentation index" or "cardio-ankle" or "CAVI" or "flow mediated dilation" or "FMD"). Results were restricted to English language articles reporting local arterial stiffness in human subjects with carotid atherosclerosis. RESULTS:Of the 1466 search results, 1085 abstracts were screened and 191 full-text articles were reviewed for relevance. The results of the 50 studies that assessed some measure of carotid arterial elasticity or stiffness in patients with carotid plaque were synthesized and reviewed. DISCUSSION:A number of different measures of carotid elasticity were found in the literature. Regardless of which metric was used, the majority of studies found increased carotid stiffness (or decreased distensibility) to be associated with carotid plaque presence, the degree of atherosclerosis, and incident stroke. CONCLUSION:Carotid artery mechanics are influenced by the presence of atherosclerotic plaque. The clinical applicability of carotid elasticity measures may be limited by the lack of reference values and standardized techniques.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Boesen ME,Singh D,Menon BK,Frayne Rdoi
10.1016/j.atherosclerosis.2015.09.008subject
Has Abstractpub_date
2015-11-01 00:00:00pages
211-22issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(15)30119-2journal_volume
243pub_type
杂志文章,评审相关文献
ATHEROSCLEROSIS文献大全abstract：:Role of enterohepatic cholesterol metabolism in obesity-induced increase of cholesterol synthesis was studied in healthy lean (BMI <24) and overweight (BMI >31) subjects by measuring serum lipids (including plant sterols, cholestanol and cholesterol precursors), cholesterol absorption % (double-label method), sterol b...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00404-4
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:Genetic variation in CC-chemokine receptor-2 (CCR2) and -5 (CCR5), and their common haplotypes, acting through inflammatory responses, may affect atherosclerosis and risk of coronary heart disease (CHD). METHOD AND RESULTS:We examined seven common variants in the CCR2 and CCR5 loci and risk of CHD among wome...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2005.06.041
更新日期：2006-05-01 00:00:00
abstract：:The fatty acid patterns of serum triglycerides and FFA in SHR and in normotensive controls aged 4, 8 and 26 weeks were estimated by gas-liquid chromatography. In serum triglycerides of SHR, the percentage of linoleic acid (C18:2) was lower and the content of arachidonic acid (C20:4) higher than in age-matched control ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(79)90119-9
更新日期：1979-06-01 00:00:00
abstract：:We have used discoidal reconstituted high density lipoproteins (rHDL) containing apolipoprotein (apo) A-I and dimyristoyl phosphatidylcholine (DMPC) as a tool to investigate the time sequence of the HDL-mediated inhibition of vascular cell adhesion molecule (VCAM)-1 and E-selectin expression in cytokine-activated huma...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00659-6
更新日期：2001-07-01 00:00:00
abstract：:Adhesion molecules and cytokines are involved in the pathogenesis of intimal injury in atherosclerosis but their relationship with endothelial function remains unclear. The objectives of this study were to examine the effects of atorvastatin on soluble adhesion molecules, interleukin-6 (IL-6) and brachial artery endot...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章
doi：10.1016/s0021-9150(03)00193-x
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND AND AIMS:We aimed at developing a novel risk prediction model for death from cardiovascular disease (CVD) for Chinese individuals, based upon a large cohort from Taiwan. METHODS:This Chinese cohort came from Taiwan, with 381,963 individuals free from CVD, recruited from a private health surveillance program...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2017.07.016
更新日期：2017-09-01 00:00:00
abstract：:We investigated the possibility that established atherosclerosis and xanthomas in mature WHHL rabbits could be suppressed or even regressed when their serum cholesterol levels were kept extremely low. Ten-month-old WHHL rabbits were divided into 3 groups, i.e. control rabbits, sacrificed at age 10 months, and placebo ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(90)90132-3
更新日期：1990-07-01 00:00:00
abstract：SUMMARY:A type of spontaneous arteriosclerosis, described as medial sclerosis and quite distinct from atherosclerosis, was found in the aortas, coronary arteries and aortic branch arteries of free-living elephants (Loxodonta africana) in Uganda and Kenya. The lesions took the form of calcified fibrotic plaques in the i...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(75)90093-3
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVE:We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness. METHODS:The case-control st...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.08.006
更新日期：2011-12-01 00:00:00
abstract：:Twelve subjects (6 women, 6 men) were given 120 g fat orally for 2 h to study its effect on serum high density lipoproteins (HDL), HDL subfractions and apoproteins A-I and A-II. In addition, we measured the fasting activity of adipose tissue lipoprotein lipase (LPL). The HDL2 mass concentration increased significantly...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(86)90040-7
更新日期：1986-02-01 00:00:00
abstract：:The current epidemic of obesity with the associated increasing incidence of insulin resistance, diabetes mellitus and atherosclerosis affecting a large proportion of the North American and Western populations, has generated a strong interest in the potential role of visceral adipose tissue in the development of athero...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2013.12.023
更新日期：2014-03-01 00:00:00
abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(91)90015-u
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVE:Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including atherosclerosis. We investigated the regulation of arginase...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2009.10.031
更新日期：2010-05-01 00:00:00
abstract：:Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53+/-1 yea...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.03.017
更新日期：2008-03-01 00:00:00
abstract：:Endothelial cells (EC) were harvested by 0.1% collagenase treatment for adult human thoracic aortas obtained 1-3 h after sudden death. At least 35-70% of EC were removed from the intimal surface of aorta, 90-95% of them being viable. Plating efficiency was 70-80%. Monolayer formation was achieved at a seeding density ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(86)90027-4
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:To summarize the evidence with respect to sugar sweetened beverages (SSBs) consumption and risk of coronary heart disease (CHD) and to recommend field standards for future analysis on this topic. METHODS:We searched for articles published up to February 2013 through PubMed, EMbase, and Cochrane Library Datab...
journal_title：Atherosclerosis
pub_type： 杂志文章,meta分析
doi：10.1016/j.atherosclerosis.2014.01.037
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:We examined the use of lipid lowering medications and control of dyslipidemia among US adults in 1999-2006. METHODS:Data were extracted from the National Health and Nutrition Examination Survey 1999-2006. RESULTS:The mean low-density lipoprotein-cholesterol (LDL-C) level significantly decreased from 3.25+/-...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2009.08.001
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-cholestero...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.atherosclerosis.2012.09.001
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Moderate red wine has been shown to reduce cardiovascular disease (CVD) risk, however the effects on certain CVD risk factors are unclear. In this study we have investigated the effects of dealcoholised red wine (DRW) and full-complement red wine (RW) on several cardiovascular risk factors in mildly hypercho...
journal_title：Atherosclerosis
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.atherosclerosis.2005.06.027
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:The aim of this study is to identify which factors influence limb salvage after bone marrow mononuclear cell implantation (BMI) in patients with chronic critical limb ischemia (CLI). METHODS:Thirteen no-option CLI patients treated with BMI were enrolled in the present study. Limb ischemia was assessed using ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2009.08.028
更新日期：2010-03-01 00:00:00
abstract：AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.06.018
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Calcific aortic valve disease is an active and progressive condition. Data indicate that aortic valve calcification (AVC) is associated with endothelial dysfunction and accepted as a manifestation of atherosclerosis. Coronary flow reserve (CFR) determined by transthoracic echocardiography has been introduced...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.07.036
更新日期：2008-04-01 00:00:00
abstract：:The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2020.05.022
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Diabetic patients are at high risk of stroke and coronary artery disease. Recent data suggest that arachidonic acid metabolism is altered in diabetic conditions and that these alterations contribute to accelerated atherosclerosis. Little is known about how these alterations affect the metabolism and...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.05.004
更新日期：2016-08-01 00:00:00
abstract：:We investigated the effects of fenofibrate, peroxisome proliferator-activated receptors (PPARs) agonist, on endothelial function in patients with hypertriglyceridemia. We administered placebo or fenofibrate 200 mg daily to 25 patients with hypertriglyceridemia for 8 weeks. This study was randomized, double-blind, plac...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.atherosclerosis.2004.01.033
更新日期：2004-06-01 00:00:00
abstract：:To test if the prevalence of genetic risk factors for coronary heart disease (CHD) is low in individuals who have reached an extremely old age, the allele frequencies of apolipoprotein E (apo E) and B (apo B) polymorphisms and plasma lipoprotein(a) levels were investigated in nonagenarians and in younger control group...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(94)90011-6
更新日期：1994-01-01 00:00:00
abstract：:Hyperlipidemic patients often have an accelerated esterified cholesterol transfer (ECT) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL). We investigated the effect of simvastatin on ECT in twelve normolipidemic subjects. After 6 weeks of simvastatin administration, ECT was de...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(93)90024-o
更新日期：1993-03-01 00:00:00
abstract：:Primary Biliary Cirrhosis (PBC) is a chronic, progressive liver disease associated with markedly elevated serum lipids, but it is not clear if PBC is associated with accelerated atherosclerosis. The present systematic review examined the relationship of PBC to atherosclerotic risk. The lipid abnormalities in PBC are c...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2006.11.036
更新日期：2007-10-01 00:00:00
abstract：:Apolipoprotein E (apo E) is a component of all the classes of lipoproteins and can be distributed among apo B- (LpB) and non apo B-containing lipoproteins (Lp-non-B). Using a new electroimmunoassay kit, plasma apo E, apo E in Lp-non-B (apo E-Lp-non-B) and apo E in LpB (apo E-LpB) levels were measured in healthy contro...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究
doi：10.1016/s0021-9150(97)00053-1
更新日期：1997-06-01 00:00:00
abstract：:Reactive oxygen species (ROS) contribute to neointimal smooth muscle proliferation by yet to be defined mechanisms. We examined the effects of a novel isoflavone 3,7-dihydroxy-isoflav-3-ene (DHIF) on development of neointimal lesions in relation to ROS elevations and cell signaling in injured arteries. Carotid arterie...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2008.09.005
更新日期：2009-05-01 00:00:00
