Abstract:
:Two ketoreductases from Candida glabrata were used for the asymmetric reduction of prochiral substituted acetophenones displayed different enantiopreference toward para-, meta-substituted and ortho-halogen substituted acetophenones with excellent enantioselectivity. Homology modeling and docking analysis were in conformity with this interested enantiopreference obtained from experimental tests. The reduction of a series of other substituted aryl ketones was also investigated using the two ketoreductases.
journal_name
Biotechnol Lettjournal_title
Biotechnology lettersauthors
Liang P,Qin B,Mu M,Zhang X,Jia X,You Sdoi
10.1007/s10529-013-1228-0subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1469-73issue
9eissn
0141-5492issn
1573-6776journal_volume
35pub_type
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更新日期:2016-05-01 00:00:00
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更新日期:2004-10-01 00:00:00
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更新日期:2008-10-01 00:00:00
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