Traffic control at the "Gut-GALT crossroads".

abstract：:This article profiles current status of spread and control of HIV/AIDS in China. China has a significant population of MSM (men who have sex with men) and they have been becoming very much alive in many ways since 1990s due to recent social changes. Some surveys indicate that great many of MSM are engaged in high-risk...

journal_title：Cell research

authors： Zhang BC,Chu QS

更新日期：2005-11-01 00:00:00

abstract：:The nucleotide sequence deduced from the amino acid sequence of the scorpion insectotoxin AaIT was chemically synthesized and was expressed in Escherichia coli. The authenticity of this in vitro expressed peptide was confirmed by N-terminal peptide sequencing. Two groups of bioassays, artificial diet incorporation ass...

journal_title：Cell research

authors： Ji SJ,Liu F,Li EQ,Zhu YX

更新日期：2002-06-01 00:00:00

abstract：:Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into a multipotent state without first establishing pluripotency. Here, w...

journal_title：Cell research

authors： Sheng C,Zheng Q,Wu J,Xu Z,Wang L,Li W,Zhang H,Zhao XY,Liu L,Wang Z,Guo C,Wu HJ,Liu Z,Wang L,He S,Wang XJ,Chen Z,Zhou Q

更新日期：2012-01-01 00:00:00

abstract：:Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cel...

journal_title：Cell research

authors： Knapp DJ,Eaves CJ

更新日期：2014-01-01 00:00:00

abstract：:Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon. ...

journal_title：Cell research

authors： Harigaya Y,Parker R

更新日期：2016-12-01 00:00:00

abstract：:Mechanical deformability is known to increase during cancer progression. Now Ma et al. identify a therapeutic strategy that targets deformable cells by microparticle-based drug delivery. ...

journal_title：Cell research

authors： Hamann J,Overholtzer M

更新日期：2016-06-01 00:00:00

abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...

journal_title：Cell research

authors： Wang X,Jiang X

更新日期：2008-08-01 00:00:00

abstract：:Transforming growth factor-beta utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream cellular res...

journal_title：Cell research

authors： Zhang YE

更新日期：2009-01-01 00:00:00

abstract：:The full-length cDNA of Pinellia ternata agglutinin (PTA) was cloned from inflorescences using RACE-PCR. Through comparative analysis of PTA gene (pta) and its deduced amino acid sequence with those of other Araceae species, pta was found to encode a precursor lectin with signal peptide and to have extensive homology ...

journal_title：Cell research

authors： Yao JH,Zhao XY,Liao ZH,Lin J,Chen ZH,Chen F,Song J,Sun XF,Tang KX

更新日期：2003-08-01 00:00:00

abstract：:Macrophages are important innate immune cells with functions in tissue repair and remodeling, induction and resolution of inflammation, as well as elimination of invading pathogens. In a recent study, Schmidt and colleagues describe the open epigenetic landscape of the human inflammatory macrophages, and the transcrip...

journal_title：Cell research

authors： Netea MG,Joosten LA

更新日期：2016-02-01 00:00:00

abstract：:Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis. The former is dependent on the IκB kinase adaptor ...

journal_title：Cell research

authors： Shih VF,Tsui R,Caldwell A,Hoffmann A

更新日期：2011-01-01 00:00:00

abstract：:Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AI...

journal_title：Cell research

authors： Donjerković D,Scott DW

更新日期：2000-09-01 00:00:00

abstract：:Our previous study showed that hydroxyurea (Hu) could induce HEL cells to express human beta-globin gene. However the molecular mechanisms by which the expression of beta-globin gene is activated and regulated are poorly understood. Here we show that the binding patterns between the core DNA sequences (HS2 core sequen...

journal_title：Cell research

authors： Zhang SB,Qian RL

更新日期：2002-12-01 00:00:00

abstract：:Parthenogenetic embryonic stem (pES) cells provide a valuable in vitro model system for studying the molecular mechanisms that underlie genomic imprinting. However, the pluripotency of pES cells and the expression profiles of paternally expressed imprinted genes have not been fully explored. In this study, three mouse...

journal_title：Cell research

authors： Jiang H,Sun B,Wang W,Zhang Z,Gao F,Shi G,Cui B,Kong X,He Z,Ding X,Kuang Y,Fei J,Sun YJ,Feng Y,Jin Y

更新日期：2007-09-01 00:00:00

abstract：:The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insigh...

journal_title：Cell research

authors： Oakley CE,Hambly BD,Curmi PM,Brown LJ

更新日期：2004-04-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) diss...

journal_title：Cell research

authors： Sang QX

更新日期：1998-09-01 00:00:00

abstract：:Leptin is the protein product encoded by the obese (ob) gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic, and diabetic. Since the cloning of leptin in 1994, our knowledge in body ...

journal_title：Cell research

authors： Huang L,Li C

更新日期：2000-06-01 00:00:00

abstract：:In order to analyze the mechanism of immuno-modulation by LPS on murine peritoneal suppressor macrophages, we have, using RNase protection assay, checked the changes of mRNA expression pattern of several cytokine genes during the immuno-modulation. It has been found that, after treating peritoneal suppressor macrophag...

journal_title：Cell research

authors： Feng WG,Chang ZL

更新日期：1998-12-01 00:00:00

abstract：:Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from phosphorylated signaling molecules, play equally important tyrosine roles as protein tyrosine kinases in signal transduction. ...

journal_title：Cell research

authors： Qu CK

更新日期：2000-12-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) carries out tumor suppressor activity in epithelial and lymphoid cells, whereas telomerase is required for most cancers. Although the molecular mechanisms by which TGF-beta acts as a tumor suppressor are yet to be fully established, a link between TGFb and its tumor suppresso...

journal_title：Cell research

authors： Li H,Xu D,Toh BH,Liu JP

更新日期：2006-02-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellul...

journal_title：Cell research

authors： Sengupta A,Banerjee B,Tyagi RK,Datta K

更新日期：2005-03-01 00:00:00

abstract：:In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we d...

journal_title：Cell research

authors： Suzuki K,Yamamoto M,Hernandez-Benitez R,Li Z,Wei C,Soligalla RD,Aizawa E,Hatanaka F,Kurita M,Reddy P,Ocampo A,Hishida T,Sakurai M,Nemeth AN,Nuñez Delicado E,Campistol JM,Magistretti P,Guillen P,Rodriguez Esteban C,G

更新日期：2019-10-01 00:00:00

abstract：:Phosphatidylinositol 3-phosphate (PI3P) plays essential roles in vesicular trafficking, organelle biogenesis and autophagy. Two class III phosphatidylinositol 3-kinase (PI3KC3) complexes have been identified in mammals, the ATG14L complex (PI3KC3-C1) and the UVRAG complex (PI3KC3-C2). PI3KC3-C1 is crucial for autophag...

journal_title：Cell research

authors： Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

更新日期：2017-08-01 00:00:00

abstract：:Neural stem cells (NSCs) constitute the cellular basis for embryonic brain development and neurogenesis. The process is regulated by NSC niche including neighbor cells such as vascular and glial cells. Since both vascular and glial cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth fac...

journal_title：Cell research

authors： Xiao Z,Kong Y,Yang S,Li M,Wen J,Li L

更新日期：2007-01-01 00:00:00

abstract：:The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin...

journal_title：Cell research

authors： Han JD

更新日期：2008-02-01 00:00:00

abstract：:Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy, particularly autophagic degradation of cellular iron storage proteins (a process known as ferritinophagy), in ferroptosis. ...

journal_title：Cell research

authors： Gao M,Monian P,Pan Q,Zhang W,Xiang J,Jiang X

更新日期：2016-09-01 00:00:00

abstract：:Intracellular redox homeostasis plays a critical role in determining tumor cells' sensitivity to drug-induced apoptosis. Here we investigated the role of thioredoxin-1 (TRX1), a key component of redox regulation, in arsenic trioxide (As(2)O(3))-induced apoptosis. Over-expression of wild-type TRX1 in HepG(2) cells led ...

journal_title：Cell research

authors： Tian C,Gao P,Zheng Y,Yue W,Wang X,Jin H,Chen Q

更新日期：2008-04-01 00:00:00

abstract：:Carotenoids, a class of natural pigments found in all photosynthetic organisms, are involved in a variety of physiological processes, including coloration, photoprotection, biosynthesis of abscisic acid (ABA) and chloroplast biogenesis. Although carotenoid biosynthesis has been well studied biochemically, the genetic ...

journal_title：Cell research

authors： Dong H,Deng Y,Mu J,Lu Q,Wang Y,Xu Y,Chu C,Chong K,Lu C,Zuo J

更新日期：2007-05-01 00:00:00

abstract：:T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5 promotes regulatory T cell generation and imm...

journal_title：Cell research

authors： Sheng W,Yang F,Zhou Y,Yang H,Low PY,Kemeny DM,Tan P,Moh A,Kaplan MH,Zhang Y,Fu XY

更新日期：2014-12-01 00:00:00