Abstract:
:Several studies have demonstrated the clonal transmission of distinct differentiation and self-renewal properties in hematopoietic stem cells during the regeneration of blood production in transplanted recipients. A recent publication now identifies Vwf expression as a discriminating marker of a hematopoietic stem cell state that is primed for platelet production in response to thrombopoietin, but also subject to developmental and other, as yet undefined, cues.
journal_name
Cell Resjournal_title
Cell researchauthors
Knapp DJ,Eaves CJdoi
10.1038/cr.2013.139subject
Has Abstractpub_date
2014-01-01 00:00:00pages
3-4issue
1eissn
1001-0602issn
1748-7838pii
cr2013139journal_volume
24pub_type
评论,杂志文章相关文献
CELL RESEARCH文献大全abstract::Differentiation of inflammatory macrophages from monocytes is characterized by an orderly integration of epigenetic and transcriptional regulatory mechanisms guided by lineage-determining transcription factors such as PU.1. Further activation of macrophages leads to a stimulus- or microenvironment-specific signal inte...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2016.1
更新日期:2016-02-01 00:00:00
abstract::Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/s41422-018-0078-7
更新日期:2018-10-01 00:00:00
abstract::The murine skeletal muscle contains hematopoietic stem cells, but this potential has so far not been studied quantitatively or qualitatively in vitro. To quantify the hematopoietic stem cell potential, we have used highly purified SP/CD45(+) cells in long-term culture initiating cell (LTC-IC) assays. The SP/CD45(+) ce...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2007.74
更新日期:2007-09-01 00:00:00
abstract::The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0208-x
更新日期:2019-09-01 00:00:00
abstract::Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1α and Gata4 (3TF) to induce hepatic conversion i...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.36
更新日期:2017-05-01 00:00:00
abstract::In mice treated with antibiotics to deplete commensal microbiota, there is a significant overhaul of host cellular disposition and function with CX3CR1+ mononuclear phagocytic cells carrying pathogenic and non-pathogenic administered bacteria to the (messenteric lymph node) MLN, resulting in T cell stimulation and IgA...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2013.41
更新日期:2013-05-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype 1) precomplex and mature...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2012.167
更新日期:2013-03-01 00:00:00
abstract::Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine c...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2014.110
更新日期:2014-09-01 00:00:00
abstract::The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310119
更新日期:2007-02-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell research
pub_type: 已发布勘误
doi:10.1038/s41422-020-0311-z
更新日期:2020-06-01 00:00:00
abstract::The full-length cDNA of Pinellia ternata agglutinin (PTA) was cloned from inflorescences using RACE-PCR. Through comparative analysis of PTA gene (pta) and its deduced amino acid sequence with those of other Araceae species, pta was found to encode a precursor lectin with signal peptide and to have extensive homology ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290175
更新日期:2003-08-01 00:00:00
abstract::Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.92
更新日期:2011-08-01 00:00:00
abstract::α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) (hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0187-y
更新日期:2019-07-01 00:00:00
abstract::Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in ...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2016.29
更新日期:2016-04-01 00:00:00
abstract::Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aerugi...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2017.6
更新日期:2017-02-01 00:00:00
abstract::There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2012.30
更新日期:2012-05-01 00:00:00
abstract::By screening tobacco cDNA library with MCK1 as a probe, we isolated a cDNA clone NtCPK5 (accession number AY971376), which encodes a typical calcium-dependent protein kinase. Sequence analyses indicated that NtCPK5 is related to both CPKs and CRKs superfamilies and has all of the three conserved domains of CPKs. The b...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290330
更新日期:2005-08-01 00:00:00
abstract::The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2016.33
更新日期:2016-05-01 00:00:00
abstract::Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment c...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2014.138
更新日期:2014-11-01 00:00:00
abstract::circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0192-1
更新日期:2019-08-01 00:00:00
abstract::EKLF is an erythroid-specific, zinc finger-containing transcription factor essential for the activation of the mammalian beta globin gene in erythroid cells of definitive lineage. We have prepared a polyclonal anti-mouse EKLF antibody suitable for Western blotting and immunoprecipitation (IP) qualities, and used it to...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310045
更新日期:2006-04-01 00:00:00
abstract::Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We created the CRISPR-on system, a two-component transcriptional activator consisting of a nuclease-dead Cas9 (dCas9) protein fused with a transcriptional activation ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2013.122
更新日期:2013-10-01 00:00:00
abstract::During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The mechanisms underlying meiotic chromosome synapsis, DSB repair and apoptosis are not fully understood. Here...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2012.2
更新日期:2012-05-01 00:00:00
abstract::Mechanical deformability is known to increase during cancer progression. Now Ma et al. identify a therapeutic strategy that targets deformable cells by microparticle-based drug delivery. ...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2016.54
更新日期:2016-06-01 00:00:00
abstract::High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/sj.cr.7310097
更新日期:2006-10-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell research
pub_type: 已发布勘误
doi:10.1038/s41422-020-0380-z
更新日期:2020-09-01 00:00:00
abstract::NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the N...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2010.171
更新日期:2011-01-01 00:00:00
abstract::Eosinophils (Eos) have been long considered as end-stage effector cells in the hierarchical hematopoietic system. Numerous lines of evidence have suggested that Eos are multifunctional leukocytes with respect to the initiation, propagation and regulation of various inflammatory or immune reactions, especially in aller...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2018.2
更新日期:2018-03-01 00:00:00
abstract::The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crystal structure of the evolutionarily conserved domain (ECD) of Beclin 1 at 1.6 Å resolution. Beclin 1 ECD exhi...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2012.24
更新日期:2012-03-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) carries out tumor suppressor activity in epithelial and lymphoid cells, whereas telomerase is required for most cancers. Although the molecular mechanisms by which TGF-beta acts as a tumor suppressor are yet to be fully established, a link between TGFb and its tumor suppresso...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/sj.cr.7310023
更新日期:2006-02-01 00:00:00