Recombinant scorpion insectotoxin AaIT kills specifically insect cells but not human cells.

abstract：:Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...

journal_title：Cell research

authors： Achilleos A,Trainor PA

更新日期：2012-02-01 00:00:00

abstract：:Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment c...

journal_title：Cell research

authors： Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M

更新日期：2014-11-01 00:00:00

abstract：:The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 years. However, it is becoming increasingly appreciated that memory cells are also capable of mediating th...

journal_title：Cell research

authors： DiSpirito JR,Shen H

更新日期：2010-01-01 00:00:00

abstract：:Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10,236,715 base pairs, is one of the largest prokaryotic genomes ever sequenced so far....

journal_title：Cell research

authors： Zhao W,Zhong Y,Yuan H,Wang J,Zheng H,Wang Y,Cen X,Xu F,Bai J,Han X,Lu G,Zhu Y,Shao Z,Yan H,Li C,Peng N,Zhang Z,Zhang Y,Lin W,Fan Y,Qin Z,Hu Y,Zhu B,Wang S,Ding X,Zhao GP

更新日期：2010-10-01 00:00:00

abstract：:The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

journal_title：Cell research

authors： Xu H,Yi BA,Chien KR

更新日期：2012-11-01 00:00:00

abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...

journal_title：Cell research

authors： Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger

更新日期：2015-02-01 00:00:00

abstract：:α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) (hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination ...

journal_title：Cell research

authors： Liao S,Rajendraprasad G,Wang N,Eibes S,Gao J,Yu H,Wu G,Tu X,Huang H,Barisic M,Xu C

更新日期：2019-07-01 00:00:00

abstract：:Phytohormone abscisic acid (ABA) was critical for many plant growth and developmental processes including seed maturation, germination and response to environmental factors. With the purpose to detect the possible ABA related signal transduction pathways, we tried to isolate ABA-regulated genes through cDNA macroarray...

journal_title：Cell research

authors： Lin F,Xu SL,Ni WM,Chu ZQ,Xu ZH,Xue HW

更新日期：2003-02-01 00:00:00

abstract：:A paracrine regulation was recently proposed in human embryonic stem cells (hESCs) grown in mouse embryonic fibroblast (MEF)-conditioned media (MEF-CM), where hESCs spontaneously differentiate into autologous fibroblast-like cells to maintain culture homeostasis by producing TGF-beta and insulin-like growth factor-II ...

journal_title：Cell research

authors： Montes R,Ligero G,Sanchez L,Catalina P,de la Cueva T,Nieto A,Melen GJ,Rubio R,García-Castro J,Bueno C,Menendez P

更新日期：2009-06-01 00:00:00

abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...

journal_title：Cell research

authors： Wang X,Jiang X

更新日期：2008-08-01 00:00:00

abstract：:KDR (kinase insert domain receptor) phosphorylation induces several effects which lead eventually to cell proliferation and survival. The precise mechanisms by which KDR, once it is activated, communicates with the nucleus are starting to be understood but have not yet been completely unravelled. Two in vitro studies ...

journal_title：Cell research

authors： Blazquez C,Cook N,Micklem K,Harris AL,Gatter KC,Pezzella F

更新日期：2006-01-01 00:00:00

abstract：:The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with loca...

journal_title：Cell research

authors： Huang G,Zhang Y,Zhu X,Zeng C,Wang Q,Zhou Q,Tao Q,Liu M,Lei J,Yan C,Shi Y

更新日期：2020-06-01 00:00:00

abstract：:Hedgehog (Hh) signaling plays vital roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and several types of cancer. Suppressor of Fused (Su(fu)) is a conserved inhibitory component of the Hh signaling pathway, but how it is regulated remains poorly understood. Here we ...

journal_title：Cell research

authors： Liu C,Zhou Z,Yao X,Chen P,Sun M,Su M,Chang C,Yan J,Jiang J,Zhang Q

更新日期：2014-05-01 00:00:00

abstract：:Our previous study showed that hydroxyurea (Hu) could induce HEL cells to express human beta-globin gene. However the molecular mechanisms by which the expression of beta-globin gene is activated and regulated are poorly understood. Here we show that the binding patterns between the core DNA sequences (HS2 core sequen...

journal_title：Cell research

authors： Zhang SB,Qian RL

更新日期：2002-12-01 00:00:00

abstract：:In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we d...

journal_title：Cell research

authors： Suzuki K,Yamamoto M,Hernandez-Benitez R,Li Z,Wei C,Soligalla RD,Aizawa E,Hatanaka F,Kurita M,Reddy P,Ocampo A,Hishida T,Sakurai M,Nemeth AN,Nuñez Delicado E,Campistol JM,Magistretti P,Guillen P,Rodriguez Esteban C,G

更新日期：2019-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive and complex neurodegenerative disease in which the γ-secretase-mediated amyloid-β (Aβ) pathology plays an important role. We found that a multifunctional protein, β-arrestin1, facilitated the formation of NCT/APH-1 (anterior pharynx-defective phenotype 1) precomplex and mature...

journal_title：Cell research

authors： Liu X,Zhao X,Zeng X,Bossers K,Swaab DF,Zhao J,Pei G

更新日期：2013-03-01 00:00:00

abstract：:The non-canonical inflammasome triggers host cell death and inflammation upon recognition of cytosolic LPS. A recent report in Cell now shows that Outer Membrane Vesicles (OMVs) of extracellular Gram-negative bacteria can deliver LPS into the host cell cytosol. ...

journal_title：Cell research

authors： Broz P

更新日期：2016-08-01 00:00:00

abstract：:While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this p...

journal_title：Cell research

authors： Kong LW,Ding XY,Kitani H,Shiurba R,Jing NH

更新日期：1999-12-01 00:00:00

abstract：:The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...

journal_title：Cell research

authors： Lv X,Han Z,Chen H,Yang B,Yang X,Xia Y,Pan C,Fu L,Zhang S,Han H,Wu M,Zhou Z,Zhang L,Li L,Wei G,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this re...

journal_title：Cell research

authors： Zarubin T,Han J

更新日期：2005-01-01 00:00:00

abstract：:NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the N...

journal_title：Cell research

authors： Zheng C,Yin Q,Wu H

更新日期：2011-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinate the functions of the two organelles and are required for multiple cellular processes such as Ca2+ tran...

journal_title：Cell research

authors： Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

更新日期：2018-08-01 00:00:00

abstract：:By screening tobacco cDNA library with MCK1 as a probe, we isolated a cDNA clone NtCPK5 (accession number AY971376), which encodes a typical calcium-dependent protein kinase. Sequence analyses indicated that NtCPK5 is related to both CPKs and CRKs superfamilies and has all of the three conserved domains of CPKs. The b...

journal_title：Cell research

authors： Wang Y,Zhang M,Ke K,Lu YT

更新日期：2005-08-01 00:00:00

abstract：:DNA methylation and demethylation regulate many crucial biological processes in mammals and are linked to many diseases. Active DNA demethylation is believed to be catalyzed by TET proteins and a putative DNA decarboxylase that may share some similarities in sequence, structure and catalytic mechanism with isoorotate ...

journal_title：Cell research

authors： Xu S,Li W,Zhu J,Wang R,Li Z,Xu GL,Ding J

更新日期：2013-11-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00

abstract：:Aging is associated with many complex diseases. Reliable prediction of the aging process is important for assessing the risks of aging-associated diseases. However, despite intense research, so far there is no reliable aging marker. Here we addressed this problem by examining whether human 3D facial imaging features c...

journal_title：Cell research

authors： Chen W,Qian W,Wu G,Chen W,Xian B,Chen X,Cao Y,Green CD,Zhao F,Tang K,Han JD

更新日期：2015-05-01 00:00:00

abstract：:T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5 promotes regulatory T cell generation and imm...

journal_title：Cell research

authors： Sheng W,Yang F,Zhou Y,Yang H,Low PY,Kemeny DM,Tan P,Moh A,Kaplan MH,Zhang Y,Fu XY

更新日期：2014-12-01 00:00:00

abstract：:DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we ...

journal_title：Cell research

authors： Macheret M,Bhowmick R,Sobkowiak K,Padayachy L,Mailler J,Hickson ID,Halazonetis TD

更新日期：2020-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ porta...

journal_title：Cell research

authors： Li Z,Zhang X,Dong L,Pang J,Xu M,Zhong Q,Zeng MS,Yu X

更新日期：2020-10-01 00:00:00

abstract：:Dendritic cells (DCs) play a pivotal role in priming adaptive immunity. However, the involvement of DCs in controlling excessive and deleterious T cell responses remains poorly defined. Moreover, the metabolic dependence and regulation of DC function are unclear. Here we show that LKB1 signaling in DCs functions as a ...

journal_title：Cell research

authors： Wang Y,Du X,Wei J,Long L,Tan H,Guy C,Dhungana Y,Qian C,Neale G,Fu YX,Yu J,Peng J,Chi H

更新日期：2019-05-01 00:00:00