Evidence for a mouse brain-specific variant of alpha-tubulin.

abstract：:A monoclonal antibody, LC-1, recognizing lung cancer associated common antigens was obtained in authors' laboratory. Its single chain Fv fragment (ScFv) named LC-1 ScFv was constructed based on recombinant phage displayed techniques. For expression on cell membrane, LC-1 ScFv was cloned into pDisplay vector, which dir...

journal_title：Cell research

authors： Chen L,Li G,Tang L,Wang J,Ge XR

更新日期：2002-03-01 00:00:00

abstract：:Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes. Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA methylation in pre-implantation rhesus monkey embryos as well as male and female gametes studied using an optimized tagmentation-based whole-geno...

journal_title：Cell research

authors： Gao F,Niu Y,Sun YE,Lu H,Chen Y,Li S,Kang Y,Luo Y,Si C,Yu J,Li C,Sun N,Si W,Wang H,Ji W,Tan T

更新日期：2017-04-01 00:00:00

abstract：:The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein)-retinoic acid receptor alpha. The PML protein localises to a subnuclear structure called the PML nuclear domain (PML-ND), of which PML is the...

journal_title：Cell research

authors： Salomoni P,Ferguson BJ,Wyllie AH,Rich T

更新日期：2008-06-01 00:00:00

abstract：:The authors apologized for the spelling mistake of author name for Zhengyu Ju. The correct form is Zhenyu Ju. We apologize for any hassle that may have been caused by our mistake. ...

journal_title：Cell research

authors： Li Y,Zhao H,Huang X,Tang J,Zhang S,Li Y,Liu X,He L,Ju Z,Lui KO,Zhou B

更新日期：2018-08-01 00:00:00

abstract：:Previously, mouse bone marrow-derived stem cells (MSC) treated with the unspecific DNA methyltransferase inhibitor 5-azacytidine were reported to differentiate into cardiomyocytes. The aim of the present study was to investigate the efficiency of a similar differentiation strategy in human mononuclear cells obtained f...

journal_title：Cell research

authors： Balana B,Nicoletti C,Zahanich I,Graf EM,Christ T,Boxberger S,Ravens U

更新日期：2006-12-01 00:00:00

abstract：:A paracrine regulation was recently proposed in human embryonic stem cells (hESCs) grown in mouse embryonic fibroblast (MEF)-conditioned media (MEF-CM), where hESCs spontaneously differentiate into autologous fibroblast-like cells to maintain culture homeostasis by producing TGF-beta and insulin-like growth factor-II ...

journal_title：Cell research

authors： Montes R,Ligero G,Sanchez L,Catalina P,de la Cueva T,Nieto A,Melen GJ,Rubio R,García-Castro J,Bueno C,Menendez P

更新日期：2009-06-01 00:00:00

abstract：:Naïve CD4 T cells can differentiate into at least two different types of T helpers, Th1 and Th2 cells. Th2 cells, capable of producing IL-4, IL-5 and IL-13, are involved in humoral immunity against extracellular pathogens and in the induction of asthma and other allergic diseases. In this review, we summarize recent r...

journal_title：Cell research

authors： Zhu J,Yamane H,Cote-Sierra J,Guo L,Paul WE

更新日期：2006-01-01 00:00:00

abstract：:Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing a...

journal_title：Cell research

authors： Fan XQ,Guo YJ

更新日期：2001-03-01 00:00:00

abstract：:Achieving increased grain productivity has long been the overriding focus of cereal breeding programs. The ideotype approach has been used to improve rice yield potential at the International Rice Research Institute and in China. However, the genetic basis of yield-related traits in rice remains unclear. Here, we show...

journal_title：Cell research

authors： Wang S,Wu K,Qian Q,Liu Q,Li Q,Pan Y,Ye Y,Liu X,Wang J,Zhang J,Li S,Wu Y,Fu X

更新日期：2017-09-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinate the functions of the two organelles and are required for multiple cellular processes such as Ca2+ tran...

journal_title：Cell research

authors： Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

更新日期：2018-08-01 00:00:00

abstract：:circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic...

journal_title：Cell research

authors： Guarnerio J,Zhang Y,Cheloni G,Panella R,Mae Katon J,Simpson M,Matsumoto A,Papa A,Loretelli C,Petri A,Kauppinen S,Garbutt C,Nielsen GP,Deshpande V,Castillo-Martin M,Cordon-Cardo C,Dimitrios S,Clohessy JG,Batish M,Pan

更新日期：2019-08-01 00:00:00

abstract：:The rice Eui (ELONGATED UPPERMOST INTERNODE) gene encodes a cytochrome P450 monooxygenase that deactivates bioactive gibberellins (GAs). In this study, we investigated controlled expression of the Eui gene and its role in plant development. We found that Eui was differentially induced by exogenous GAs and that the Eui...

journal_title：Cell research

authors： Zhang Y,Zhu Y,Peng Y,Yan D,Li Q,Wang J,Wang L,He Z

更新日期：2008-03-01 00:00:00

abstract：:Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...

journal_title：Cell research

authors： He XB,Yan YC,Li YP,Koide SS

更新日期：2003-04-01 00:00:00

abstract：:The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...

journal_title：Cell research

authors： Wu AM,Lv SY,Liu JY

更新日期：2007-02-01 00:00:00

abstract：:One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al...

journal_title：Cell research

authors： Bach I

更新日期：2012-11-01 00:00:00

abstract：:Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards this direction. Here w...

journal_title：Cell research

authors： Yi F,Qu J,Liu GH,Izpisua Belmonte JC

更新日期：2013-01-01 00:00:00

abstract：:Exosome-mediated intercellular communication has become an emerging field of human health and diseases. A recent study published by Cell Research reports that in zebrafish neurons can remotely regulate blood-brain barrier integrity by delivering miR-132 through secretion of exosomes. ...

journal_title：Cell research

authors： Zhao Z,Zlokovic BV

更新日期：2017-07-01 00:00:00

abstract：:Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial c...

journal_title：Cell research

authors： Kang Y,Wang F,Feng J,Yang D,Yang X,Yan X

更新日期：2006-03-01 00:00:00

abstract：:In 2006, the "wall came down" that limited the experimental conversion of differentiated cells into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a handful of transcription factors (Oct4, Sox2, Klf4 and c-Myc) can convert a differentiated cell back to pluripotency over the course ...

journal_title：Cell research

authors： Papp B,Plath K

更新日期：2011-03-01 00:00:00

abstract：:MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Micr...

journal_title：Cell research

authors： Wang F,Song W,Zhao H,Ma Y,Li Y,Zhai D,Pi J,Si Y,Xu J,Dong L,Su R,Zhang M,Zhu Y,Ren X,Miao F,Liu W,Li F,Zhang J,He A,Shan G,Hui J,Wang L,Yu J

更新日期：2017-03-01 00:00:00

abstract：:The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...

journal_title：Cell research

authors： Zhang Z,Wang M,Xie D,Huang Z,Zhang L,Yang Y,Ma D,Li W,Zhou Q,Yang YG,Wang XJ

更新日期：2018-11-01 00:00:00

abstract：:The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

journal_title：Cell research

authors： Xu H,Yi BA,Chien KR

更新日期：2012-11-01 00:00:00

abstract：:DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have propos...

journal_title：Cell research

authors： Borges HL,Linden R,Wang JY

更新日期：2008-01-01 00:00:00

abstract：:Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microgl...

journal_title：Cell research

authors： Tang M,Xie Q,Gimple RC,Zhong Z,Tam T,Tian J,Kidwell RL,Wu Q,Prager BC,Qiu Z,Yu A,Zhu Z,Mesci P,Jing H,Schimelman J,Wang P,Lee D,Lorenzini MH,Dixit D,Zhao L,Bhargava S,Miller TE,Wan X,Tang J,Sun B,Cravatt

更新日期：2020-10-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:Eosinophils (Eos) have been long considered as end-stage effector cells in the hierarchical hematopoietic system. Numerous lines of evidence have suggested that Eos are multifunctional leukocytes with respect to the initiation, propagation and regulation of various inflammatory or immune reactions, especially in aller...

journal_title：Cell research

authors： Zhang C,Yi W,Li F,Du X,Wang H,Wu P,Peng C,Luo M,Hua W,Wong CC,Lee JJ,Li W,Chen Z,Ying S,Ju Z,Shen H

更新日期：2018-03-01 00:00:00

abstract：:Phytohormone abscisic acid (ABA) was critical for many plant growth and developmental processes including seed maturation, germination and response to environmental factors. With the purpose to detect the possible ABA related signal transduction pathways, we tried to isolate ABA-regulated genes through cDNA macroarray...

journal_title：Cell research

authors： Lin F,Xu SL,Ni WM,Chu ZQ,Xu ZH,Xue HW

更新日期：2003-02-01 00:00:00

abstract：:Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedback loop to promote i...

journal_title：Cell research

authors： Zhou Y,Li M,Xue Y,Li Z,Wen W,Liu X,Ma Y,Zhang L,Shen Z,Cao X

更新日期：2019-08-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder often considered to be the third most common muscular dystrophy. Deletions reducing the copy number of the D4Z4 repeat in the distal end of the 4q arm are the main genetic cause of the disease. The recently highlighted research has identified a ...

journal_title：Cell research

authors： Vizoso M,Esteller M

更新日期：2012-10-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00