Abstract:
:Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial cells. Our data showed that CD146 siRNA specifically blocked the expression of CD146 on both mRNA and protein levels, leading to the significant suppression of HUVEC proliferation, adhesion and migration. These results demonstrate that CD146 plays a key role in vascular endothelial cell activity and angiogenesis, and CD146 siRNA can be used as a new inhibitor for anti-angiogenesis therapy.
journal_name
Cell Resjournal_title
Cell researchauthors
Kang Y,Wang F,Feng J,Yang D,Yang X,Yan Xdoi
10.1038/sj.cr.7310039keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
313-8issue
3eissn
1001-0602issn
1748-7838pii
7310039journal_volume
16pub_type
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