Abstract:
:While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.
journal_name
Cell Resjournal_title
Cell researchauthors
Covarrubias A,Byles V,Horng Tdoi
10.1038/cr.2013.88subject
Has Abstractpub_date
2013-08-01 00:00:00pages
984-5issue
8eissn
1001-0602issn
1748-7838pii
cr201388journal_volume
23pub_type
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