解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0362-1
更新日期:2021-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the microenvironment contributes to NPC progression and immune evasion remains unclear. Here we performed single-cell RNA sequencing on ~104,000 cells from...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-00402-8
更新日期:2020-11-01 00:00:00
abstract::DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0358-x
更新日期:2020-11-01 00:00:00
abstract::Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system. While the hormone epinephrine binds β1AR and β2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-00424-2
更新日期:2020-10-22 00:00:00
abstract::Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ porta...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0363-0
更新日期:2020-10-01 00:00:00
abstract::Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microgl...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0338-1
更新日期:2020-10-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell research
pub_type: 已发布勘误
doi:10.1038/s41422-020-0380-z
更新日期:2020-09-01 00:00:00
abstract::Calcium-dependent proteolytic calpains are implicated in a variety of physiological processes, as well as pathologies associated with calcium overload. However, the mechanism by which calpain is activated remains elusive since intracellular calcium levels under physiological conditions do not reach the high concentrat...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0388-4
更新日期:2020-08-26 00:00:00
abstract::The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with loca...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0319-4
更新日期:2020-06-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell research
pub_type: 已发布勘误
doi:10.1038/s41422-020-0311-z
更新日期:2020-06-01 00:00:00
abstract::The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to mi...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0280-2
更新日期:2020-05-01 00:00:00
abstract::Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage. A number of innate immune receptors have been reported to serve as inflammasome sensors. Activation of these sensors leads to the proteolytic activation of ca...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0295-8
更新日期:2020-04-01 00:00:00
abstract::N6-methyladenine (N6-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N6-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation. Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N6-mA in unpairing regions (e.g.,...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0237-5
更新日期:2020-03-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell research
pub_type: 已发布勘误
doi:10.1038/s41422-019-0262-4
更新日期:2020-02-01 00:00:00
abstract::In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we d...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0213-0
更新日期:2019-10-01 00:00:00
abstract::Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC) comprises various molecular subgroups with unclear identities and currently has few targeted treatment options. Our previous study identified protein C receptor (Procr) as a surface marker on mammary stem cells (MaSCs) locate...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0225-9
更新日期:2019-10-01 00:00:00
abstract::The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0208-x
更新日期:2019-09-01 00:00:00
abstract::circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0192-1
更新日期:2019-08-01 00:00:00
abstract::Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedback loop to promote i...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0193-0
更新日期:2019-08-01 00:00:00
abstract::α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) (hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0187-y
更新日期:2019-07-01 00:00:00
abstract::Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0168-1
更新日期:2019-06-01 00:00:00
abstract::Dendritic cells (DCs) play a pivotal role in priming adaptive immunity. However, the involvement of DCs in controlling excessive and deleterious T cell responses remains poorly defined. Moreover, the metabolic dependence and regulation of DC function are unclear. Here we show that LKB1 signaling in DCs functions as a ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0157-4
更新日期:2019-05-01 00:00:00
abstract::Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-019-0153-8
更新日期:2019-04-01 00:00:00
abstract::Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease. The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen. In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH) levels become el...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0123-6
更新日期:2019-02-01 00:00:00
abstract::The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be converted to liver progenitor-like cel...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0103-x
更新日期:2019-01-01 00:00:00
abstract::While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0113-8
更新日期:2019-01-01 00:00:00
abstract::The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0092-9
更新日期:2018-11-01 00:00:00
abstract::Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/s41422-018-0078-7
更新日期:2018-10-01 00:00:00
abstract::The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinate the functions of the two organelles and are required for multiple cellular processes such as Ca2+ tran...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0065-z
更新日期:2018-08-01 00:00:00
abstract::The authors apologized for the spelling mistake of author name for Zhengyu Ju. The correct form is Zhenyu Ju. We apologize for any hassle that may have been caused by our mistake. ...
journal_title:Cell research
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41422-018-0063-1
更新日期:2018-08-01 00:00:00
abstract::Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic ...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/s41422-018-0013-y
更新日期:2018-04-01 00:00:00
abstract::Eosinophils (Eos) have been long considered as end-stage effector cells in the hierarchical hematopoietic system. Numerous lines of evidence have suggested that Eos are multifunctional leukocytes with respect to the initiation, propagation and regulation of various inflammatory or immune reactions, especially in aller...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2018.2
更新日期:2018-03-01 00:00:00
abstract::Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that t...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2018.1
更新日期:2018-02-01 00:00:00
abstract::Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually considered a non-inflammatory process while necrosis triggers inflammation. Recent studies on necroptosis and pyroptosis, two types of programmed necrosis, reve...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2017.133
更新日期:2018-01-01 00:00:00
abstract::Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.139
更新日期:2018-01-01 00:00:00
abstract::A recent study led by Professor Rob Martienssen in Cell showed that 3'-tRNA-derived small RNAs can suppress long terminal repeat retrotransposon activity in mammalian cells by mechanisms independent of DNA-associated epigenetic marks, suggesting how the genome may defend itself from retrotransposon invasion during epi...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2017.109
更新日期:2017-11-01 00:00:00
abstract::Intermittent fasting (IF) has been shown to promote metabolic health in several organisms. Two recent papers show that IF induces white adipose tissue beiging and increases thermogenesis, which improves metabolic health in mice. ...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2017.130
更新日期:2017-11-01 00:00:00
abstract::New plant type (NPT) or ideal plant architecture (IPA) is an attractive way of increasing yield potential by promoting high resource use efficiency combined with better lodging resistance. In a recent paper in Cell Research, Wang et al. describe how a QTL they identified could bring about the desired NPT architecture ...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2017.115
更新日期:2017-10-01 00:00:00
abstract::Achieving increased grain productivity has long been the overriding focus of cereal breeding programs. The ideotype approach has been used to improve rice yield potential at the International Rice Research Institute and in China. However, the genetic basis of yield-related traits in rice remains unclear. Here, we show...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.98
更新日期:2017-09-01 00:00:00
abstract::Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive drug target. Here, we developed a split luciferase complementation-based high-throughput screening assay to id...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.88
更新日期:2017-08-01 00:00:00