Author Correction: 863 genomes reveal the origin and domestication of chicken.

abstract：:Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapper1 (Dpr1) acts as a critical regulator of the ...

journal_title：Cell research

authors： Ma B,Cao W,Li W,Gao C,Qi Z,Zhao Y,Du J,Xue H,Peng J,Wen J,Chen H,Ning Y,Huang L,Zhang H,Gao X,Yu L,Chen YG

更新日期：2014-08-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the microenvironment contributes to NPC progression and immune evasion remains unclear. Here we performed single-cell RNA sequencing on ~104,000 cells from...

journal_title：Cell research

authors： Jin S,Li R,Chen MY,Yu C,Tang LQ,Liu YM,Li JP,Liu YN,Luo YL,Zhao Y,Zhang Y,Xia TL,Liu SX,Liu Q,Wang GN,You R,Peng JY,Li J,Han F,Wang J,Chen QY,Zhang L,Mai HQ,Gewurz BE,Zhao B,Young LS,Zhong Q,Bai F,

更新日期：2020-11-01 00:00:00

abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...

journal_title：Cell research

authors： Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger

更新日期：2015-02-01 00:00:00

abstract：:Fishes, the biggest and most diverse community in vertebrates are good experimental models for studies of cell and developmental biology by many favorable characteristics. Nuclear transplantation in fish has been thoroughly studied in China since 1960s. Fish nuclei of embryonic cells from different genera were transpl...

journal_title：Cell research

authors： Zhu ZY,Sun YH

更新日期：2000-03-01 00:00:00

abstract：:The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

journal_title：Cell research

authors： Xu H,Yi BA,Chien KR

更新日期：2012-11-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

journal_title：Cell research

authors： Wang C,Chen X,Wang Y,Gong J,Hu G

更新日期：2007-04-01 00:00:00

abstract：:It is well documented that g-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosome reaction induced by GABA and progesterone. GABA transporter I (GAT1) also existed in testis and sperm, bu...

journal_title：Cell research

authors： Hu JH,Zhang JF,Ma YH,Jiang J,Yang N,Li XB,Yu Chi ZG,Fei J,Guo LH

更新日期：2004-02-01 00:00:00

abstract：:Various factors/pathways including hormonal regulation have been suggested to control herpes simplex virus type 1 (HSV-1) latency and reactivation. Our computer analysis identified a DNA repeat containing thyroid hormone-responsive elements (TRE) in the regulatory region of HSV-1 latency-associated transcript (LAT). T...

journal_title：Cell research

authors： Bedadala GR,Pinnoji RC,Palem JR,Hsia SC

更新日期：2010-05-01 00:00:00

abstract：:DNA replication stress, a feature of human cancers, often leads to instability at specific genomic loci, such as the common fragile sites (CFSs). Cells experiencing DNA replication stress may also exhibit mitotic DNA synthesis (MiDAS). To understand the physiological function of MiDAS and its relationship to CFSs, we ...

journal_title：Cell research

authors： Macheret M,Bhowmick R,Sobkowiak K,Padayachy L,Mailler J,Hickson ID,Halazonetis TD

更新日期：2020-11-01 00:00:00

abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...

journal_title：Cell research

authors： Wu FS

更新日期：2005-11-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) was originally recognized for its ability to promote survival of midbrain dopaminergic neurons, but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations, including motor neurons, sympathetic neurons, sensory...

journal_title：Cell research

authors： Jiao L,Zhang Y,Hu C,Wang YG,Huang A,He C

更新日期：2011-02-01 00:00:00

abstract：:Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic ...

journal_title：Cell research

authors： Pan T

更新日期：2018-04-01 00:00:00

abstract：:Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...

journal_title：Cell research

authors： Zhang Q,Meng Y,Zhang L,Chen J,Zhu D

更新日期：2009-03-01 00:00:00

abstract：:The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here we demonstrate that ML...

journal_title：Cell research

authors： Xia B,Fang S,Chen X,Hu H,Chen P,Wang H,Gao Z

更新日期：2016-05-01 00:00:00

abstract：:Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial c...

journal_title：Cell research

authors： Kang Y,Wang F,Feng J,Yang D,Yang X,Yan X

更新日期：2006-03-01 00:00:00

abstract：:Hedgehog (Hh) signaling plays vital roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and several types of cancer. Suppressor of Fused (Su(fu)) is a conserved inhibitory component of the Hh signaling pathway, but how it is regulated remains poorly understood. Here we ...

journal_title：Cell research

authors： Liu C,Zhou Z,Yao X,Chen P,Sun M,Su M,Chang C,Yan J,Jiang J,Zhang Q

更新日期：2014-05-01 00:00:00

abstract：:The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with loca...

journal_title：Cell research

authors： Huang G,Zhang Y,Zhu X,Zeng C,Wang Q,Zhou Q,Tao Q,Liu M,Lei J,Yan C,Shi Y

更新日期：2020-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Guarnerio J,Zhang Y,Cheloni G,Panella R,Katon JM,Simpson M,Matsumoto A,Papa A,Loretelli C,Petri A,Kauppinen S,Garbutt C,Nielsen GP,Deshpande V,Castillo-Martin M,Cordon-Cardo C,Spentzos D,Clohessy JG,Batish M,Pandolf

更新日期：2020-02-01 00:00:00

abstract：:Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an under...

journal_title：Cell research

authors： Figeys D

更新日期：2008-07-01 00:00:00

abstract：:Dysregulation of beta-site APP-cleaving enzyme (BACE) and/or gamma-secretase leads to anomalous production of amyloid-beta peptide (Abeta) and contributes to the etiology of Alzheimer's disease (AD). Since these secretases mediate proteolytic processing of numerous proteins, little success has been achieved to treat A...

journal_title：Cell research

authors： Teng L,Zhao J,Wang F,Ma L,Pei G

更新日期：2010-02-01 00:00:00

abstract：:Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedback loop to promote i...

journal_title：Cell research

authors： Zhou Y,Li M,Xue Y,Li Z,Wen W,Liu X,Ma Y,Zhang L,Shen Z,Cao X

更新日期：2019-08-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00

abstract：:The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...

journal_title：Cell research

authors： Wu AM,Lv SY,Liu JY

更新日期：2007-02-01 00:00:00

abstract：:The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...

journal_title：Cell research

authors： Lv X,Han Z,Chen H,Yang B,Yang X,Xia Y,Pan C,Fu L,Zhang S,Han H,Wu M,Zhou Z,Zhang L,Li L,Wei G,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...

journal_title：Cell research

authors： Ren S,Peng Z,Mao JH,Yu Y,Yin C,Gao X,Cui Z,Zhang J,Yi K,Xu W,Chen C,Wang F,Guo X,Lu J,Yang J,Wei M,Tian Z,Guan Y,Tang L,Xu C,Wang L,Gao X,Tian W,Wang J,Yang H,Wang J,Sun Y

更新日期：2012-05-01 00:00:00

abstract：:While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation...

journal_title：Cell research

authors： Covarrubias A,Byles V,Horng T

更新日期：2013-08-01 00:00:00

abstract：:Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk between tumor and stromal cells. However, how PGE2-mediated signaling modulates t...

journal_title：Cell research

authors： Li P,Shan JX,Chen XH,Zhang D,Su LP,Huang XY,Yu BQ,Zhi QM,Li CL,Wang YQ,Tomei S,Cai Q,Ji J,Li JF,Chouchane L,Yu YY,Sun FZ,Xu ZH,Liu BY,Zhu ZG

更新日期：2015-05-01 00:00:00

abstract：:Macrophages are important innate immune cells with functions in tissue repair and remodeling, induction and resolution of inflammation, as well as elimination of invading pathogens. In a recent study, Schmidt and colleagues describe the open epigenetic landscape of the human inflammatory macrophages, and the transcrip...

journal_title：Cell research

authors： Netea MG,Joosten LA

更新日期：2016-02-01 00:00:00

abstract：:NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the N...

journal_title：Cell research

authors： Zheng C,Yin Q,Wu H

更新日期：2011-01-01 00:00:00