Abstract：
:UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (a UV-B-specific photoreceptor), COP1 (a WD40-repeat-containing RING finger protein), HY5 (a basic zipper transcription factor), and RUP1/2 (two UVR8-interacting proteins). Here we report that Arabidopsis SALT TOLERANCE (STO/BBX24), a known regulator for light signaling in plants, defines a new signaling component in UV-B-mediated photomorphogenesis. The bbx24 mutant is hypersensitive to UV-B radiation and becomes extremely dwarfed under UV-B treatment. By contrast, BBX24 overexpression transgenic lines respond much more weakly to UV-B than the bbx24 and wild-type plants. BBX24 expression is UV-B-inducible and its accumulation under UV-B requires COP1. Co-immunoprecipitation experiments indicate that BBX24 interacts with COP1 in planta upon UV-B illumination. Moreover, BBX24 interacts with HY5 and acts antagonistically with HY5 in UV-B-induced inhibition of hypocotyl elongation. Furthermore, BBX24 attenuates UV-B-induced HY5 accumulation and suppresses its transcription-activation activity. Taken together, our results reveal a previously uncharacterized function of the light-regulated BBX24 in UV-B responses and demonstrate that BBX24 functions as a negative regulator of photomorphogenic UV-B responses by interacting with both COP1 and HY5. The UV-B-inducible expression pattern and its suppression of HY5 activity suggest that BBX24 could be a new component of the feedback regulatory module of UV-B signaling in plants.
journal_name
Cell Resjournal_title
Cell researchauthors
Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SSdoi
10.1038/cr.2012.34subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1046-57issue
6eissn
1001-0602issn
1748-7838pii
cr201234journal_volume
22pub_type
杂志文章相关文献
CELL RESEARCH文献大全abstract：:Calcium-dependent proteolytic calpains are implicated in a variety of physiological processes, as well as pathologies associated with calcium overload. However, the mechanism by which calpain is activated remains elusive since intracellular calcium levels under physiological conditions do not reach the high concentrat...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-020-0388-4
更新日期：2020-08-26 00:00:00
abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2015.3
更新日期：2015-02-01 00:00:00
abstract：:DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have propos...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2007.110
更新日期：2008-01-01 00:00:00
abstract：:Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory responses. Mechanistically, it involves a cascade of cellular events precisely regulated by temporal and spatial pres...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/sj.cr.7290071
更新日期：2001-06-01 00:00:00
abstract：:Morphologically, caveolae and lipid rafts are two different membrane structures. They are often reported to share similar lipid and protein compositions, and are considered to be two subtypes of membrane lipid microdomains. By modifying sucrose density gradient flotation centrifugation, which is used to isolate lipid ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2009.27
更新日期：2009-04-01 00:00:00
abstract：:Human polymorphonuclear leukocytes (PMN) have been reported to completely lack of DNA-dependent protein kinase (DNA-PK) which is composed of Ku protein and the catalytic subunit DNA-PKcs, needed for nonhomologous end-joining (NHEJ) of DNA double-strand breaks. Promyelocytic HL-60 cells express a variant form of Ku res...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290233
更新日期：2004-08-01 00:00:00
abstract：:The term epigenetics refers to heritable changes not encoded by DNA. The organization of DNA into chromatin fibers affects gene expression in a heritable manner and is therefore one mechanism of epigenetic inheritance. Large parts of eukaryotic genomes consist of constitutively highly condensed heterochromatin, import...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2009.13
更新日期：2009-03-01 00:00:00
abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aerugi...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2017.6
更新日期：2017-02-01 00:00:00
abstract：:Spontaneous Ca2+ oscillations in vascular smooth muscle cells have been modeled using a single Ca2+ pool. This report describes spontaneous Ca2+ oscillations dependent on two separate Ca2+ sources for the nuclear versus cytoplasmic compartments. Changes in free intracellular Ca2+ were monitored with ratiometric Ca2+- ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290238
更新日期：2004-10-01 00:00:00
abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290369
更新日期：2005-11-01 00:00:00
abstract：:The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-019-0208-x
更新日期：2019-09-01 00:00:00
abstract：:Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors. More recently,...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2008.273
更新日期：2008-09-01 00:00:00
abstract：:Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microgl...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-020-0338-1
更新日期：2020-10-01 00:00:00
abstract：:A paracrine regulation was recently proposed in human embryonic stem cells (hESCs) grown in mouse embryonic fibroblast (MEF)-conditioned media (MEF-CM), where hESCs spontaneously differentiate into autologous fibroblast-like cells to maintain culture homeostasis by producing TGF-beta and insulin-like growth factor-II ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2009.35
更新日期：2009-06-01 00:00:00
abstract：:Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Using hepatic-specific transcription factors Foxa3, Hnf1α and Gata4 (3TF) to induce hepatic conversion i...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2017.36
更新日期：2017-05-01 00:00:00
abstract：:The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interaction between Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showed Ese-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by a...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290310
更新日期：2005-06-01 00:00:00
abstract：:A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. We proposed that NF-kappaB transcription factors regulated via the IkappaB kinase (IKK) complex play a critical role in coupling inflammation and cancer and h...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2008.30
更新日期：2008-03-01 00:00:00
abstract：:A wide variety of neurons and glial cells differentiate from common precursor cells in the developing nervous system. During this process, Notch-mediated cell-cell interaction is essential for maintenance of dividing cells and subsequent generation of cell type diversity. Activation of Notch inhibits cellular differen...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/sj.cr.7290016
更新日期：1999-09-01 00:00:00
abstract：:Various factors/pathways including hormonal regulation have been suggested to control herpes simplex virus type 1 (HSV-1) latency and reactivation. Our computer analysis identified a DNA repeat containing thyroid hormone-responsive elements (TRE) in the regulatory region of HSV-1 latency-associated transcript (LAT). T...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2010.50
更新日期：2010-05-01 00:00:00
abstract：:Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290156
更新日期：2003-04-01 00:00:00
abstract：:High sodium consumption has been raising interest as a putative environmental factor linking Western lifestyle to the growing epidemic of autoimmune and inflammatory diseases. Now Zhang and colleagues show that high sodium drives macrophage to acquire a new proinflammatory effector phenotype with a distinct signature,...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2015.91
更新日期：2015-08-01 00:00:00
abstract：:Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2017.70
更新日期：2017-06-01 00:00:00
abstract：:The TGF-beta superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction path...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/sj.cr.7290246
更新日期：2004-12-01 00:00:00
abstract：:Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/s41422-018-0078-7
更新日期：2018-10-01 00:00:00
abstract：:N6-methyladenine (N6-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N6-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation. Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N6-mA in unpairing regions (e.g.,...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-019-0237-5
更新日期：2020-03-01 00:00:00
abstract：:Plant reproduction is initiated by the specification of sporocytes that form haploid spores through meiosis. A new study in Arabidopsis published in Cell Research shows how the product of sporocyteless/nozzle, a key gene in this process, partners with co-repressors and transcription factors to promote spore formation,...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2014.164
更新日期：2015-01-01 00:00:00
abstract：:Heterotrimeric G proteins are known to function as messengers in numerous signal transduction pathways. The null mutation of RGA (rice heterotrimeric G protein alpha subunit), which encodes the alpha subunit of heterotrimeric G protein in rice, causes severe dwarfism and reduced responsiveness to gibberellic acid in r...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7310111
更新日期：2006-12-01 00:00:00
abstract：:Neural stem cells (NSCs) constitute the cellular basis for embryonic brain development and neurogenesis. The process is regulated by NSC niche including neighbor cells such as vascular and glial cells. Since both vascular and glial cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth fac...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7310126
更新日期：2007-01-01 00:00:00
abstract：:The aneuploid with isochromosome or telochromosome is ideal material for exploring the position of centromere in lingkage map. For obtaining these aneuploids in rice, the primary trisomics from triplo-1 to triplo-12 and the aneuploids derived from a triploid of indica rice variety Zhongxian 3037 were carefully investi...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.1997.4
更新日期：1997-06-01 00:00:00
abstract：:Beta adrenergic receptors (βARs) mediate physiologic responses to the catecholamines epinephrine and norepinephrine released by the sympathetic nervous system. While the hormone epinephrine binds β1AR and β2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-020-00424-2
更新日期：2020-10-22 00:00:00
