NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly.

abstract：:Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive ...

journal_title：Cell research

authors： Gao R,Liang X,Cheedipudi S,Cordero J,Jiang X,Zhang Q,Caputo L,Günther S,Kuenne C,Ren Y,Bhattacharya S,Yuan X,Barreto G,Chen Y,Braun T,Evans SM,Sun Y,Dobreva G

更新日期：2019-06-01 00:00:00

abstract：:A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...

journal_title：Cell research

authors： Xia HC,Li F,Li Z,Zhang ZC

更新日期：2003-10-01 00:00:00

abstract：:A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. We proposed that NF-kappaB transcription factors regulated via the IkappaB kinase (IKK) complex play a critical role in coupling inflammation and cancer and h...

journal_title：Cell research

authors： Karin M

更新日期：2008-03-01 00:00:00

abstract：:Cotton fibers elongate rapidly after initiation of elongation, eventually leading to the deposit of a large amount of cellulose. To reveal features of cotton fiber cells at the fast elongation and the secondary cell wall synthesis stages, we compared the respective transcriptomes and metabolite profiles. Comparative a...

journal_title：Cell research

authors： Gou JY,Wang LJ,Chen SP,Hu WL,Chen XY

更新日期：2007-05-01 00:00:00

abstract：:UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (...

journal_title：Cell research

authors： Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SS

更新日期：2012-06-01 00:00:00

abstract：:Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable individuals, pSNMs have never been identified at whole-genome scale largely due to technical difficulties an...

journal_title：Cell research

authors： Huang AY,Xu X,Ye AY,Wu Q,Yan L,Zhao B,Yang X,He Y,Wang S,Zhang Z,Gu B,Zhao HQ,Wang M,Gao H,Gao G,Zhang Z,Yang X,Wu X,Zhang Y,Wei L

更新日期：2014-11-01 00:00:00

abstract：:Human carcinomas are comprised of complex mixtures of tumor cells that are known to compete indirectly for nutrients and growth factors. Whether tumor cells could also compete directly, for example by elimination of rivals, is not known. Here we show that human cells can directly compete by a mechanism of engulfment c...

journal_title：Cell research

authors： Sun Q,Luo T,Ren Y,Florey O,Shirasawa S,Sasazuki T,Robinson DN,Overholtzer M

更新日期：2014-11-01 00:00:00

abstract：:Differentiation of inflammatory macrophages from monocytes is characterized by an orderly integration of epigenetic and transcriptional regulatory mechanisms guided by lineage-determining transcription factors such as PU.1. Further activation of macrophages leads to a stimulus- or microenvironment-specific signal inte...

journal_title：Cell research

authors： Schmidt SV,Krebs W,Ulas T,Xue J,Baßler K,Günther P,Hardt AL,Schultze H,Sander J,Klee K,Theis H,Kraut M,Beyer M,Schultze JL

更新日期：2016-02-01 00:00:00

abstract：:Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of the central nervous system. It is known that neural cells can regulate brain vascular integrity. However, due to the high complexity of neurovascular interactions involved, understanding o...

journal_title：Cell research

authors： Xu B,Zhang Y,Du XF,Li J,Zi HX,Bu JW,Yan Y,Han H,Du JL

更新日期：2017-07-01 00:00:00

abstract：:MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabditis elegans. In this paper, we show that a mutant Arabidopsis plant carrying the putative disrupted AtMSH5...

journal_title：Cell research

authors： Lu X,Liu X,An L,Zhang W,Sun J,Pei H,Meng H,Fan Y,Zhang C

更新日期：2008-05-01 00:00:00

abstract：:Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited a...

journal_title：Cell research

authors： Hennersdorf F,Florian S,Jakob A,Baumgärtner K,Sonneck K,Nordheim A,Biedermann T,Valent P,Bühring HJ

更新日期：2005-05-01 00:00:00

abstract：:DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site thr...

journal_title：Cell research

authors： Lai F,Shiekhattar R

更新日期：2014-03-01 00:00:00

abstract：:All known subtypes of influenza A viruses are maintained in wild waterfowl, the natural reservoir of these viruses. Influenza A viruses are isolated from a variety of animal species with varying morbidity and mortality rates. More importantly, influenza A viruses cause respiratory disease in humans with potentially fa...

journal_title：Cell research

authors： Neumann G,Chen H,Gao GF,Shu Y,Kawaoka Y

更新日期：2010-01-01 00:00:00

abstract：:Mitochondria have long been considered to be the powerhouse of the living cell, generating energy in the form of the molecule ATP via the process of oxidative phosphorylation. In the past 20 years, it has been recognised that they also play an important role in the implementation of apoptosis, or programmed cell death...

journal_title：Cell research

authors： Xu W,Charles IG,Moncada S

更新日期：2005-01-01 00:00:00

abstract：:The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...

journal_title：Cell research

authors： Zhang Z,Wang M,Xie D,Huang Z,Zhang L,Yang Y,Ma D,Li W,Zhou Q,Yang YG,Wang XJ

更新日期：2018-11-01 00:00:00

abstract：:During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The mechanisms underlying meiotic chromosome synapsis, DSB repair and apoptosis are not fully understood. Here...

journal_title：Cell research

authors： Xu J,Sun X,Jing Y,Wang M,Liu K,Jian Y,Yang M,Cheng Z,Yang C

更新日期：2012-05-01 00:00:00

abstract：:Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...

journal_title：Cell research

authors： Schneider T,Bindereif A

更新日期：2017-06-01 00:00:00

abstract：:Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease. The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen. In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH) levels become el...

journal_title：Cell research

authors： Guo Y,Zhao M,Bo T,Ma S,Yuan Z,Chen W,He Z,Hou X,Liu J,Zhang Z,Zhu Q,Wang Q,Lin X,Yang Z,Cui M,Liu L,Li Y,Yu C,Qi X,Wang Q,Zhang H,Guan Q,Zhao L,Xuan S,Yan H,Lin Y,Wang L,Li Q,Song Y,Gao L,Zhao

更新日期：2019-02-01 00:00:00

abstract：:High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...

journal_title：Cell research

authors： Cutri BA,Hime NJ,Nicholls SJ

更新日期：2006-10-01 00:00:00

abstract：:We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive eff...

journal_title：Cell research

authors： Huang Y,Ding XY

更新日期：1999-03-01 00:00:00

abstract：:The authors apologized for the spelling mistake of author name for Zhengyu Ju. The correct form is Zhenyu Ju. We apologize for any hassle that may have been caused by our mistake. ...

journal_title：Cell research

authors： Li Y,Zhao H,Huang X,Tang J,Zhang S,Li Y,Liu X,He L,Ju Z,Lui KO,Zhou B

更新日期：2018-08-01 00:00:00

abstract：:Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellul...

journal_title：Cell research

authors： Sengupta A,Banerjee B,Tyagi RK,Datta K

更新日期：2005-03-01 00:00:00

abstract：:The non-canonical inflammasome triggers host cell death and inflammation upon recognition of cytosolic LPS. A recent report in Cell now shows that Outer Membrane Vesicles (OMVs) of extracellular Gram-negative bacteria can deliver LPS into the host cell cytosol. ...

journal_title：Cell research

authors： Broz P

更新日期：2016-08-01 00:00:00

abstract：:By screening tobacco cDNA library with MCK1 as a probe, we isolated a cDNA clone NtCPK5 (accession number AY971376), which encodes a typical calcium-dependent protein kinase. Sequence analyses indicated that NtCPK5 is related to both CPKs and CRKs superfamilies and has all of the three conserved domains of CPKs. The b...

journal_title：Cell research

authors： Wang Y,Zhang M,Ke K,Lu YT

更新日期：2005-08-01 00:00:00

abstract：:Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here,...

journal_title：Cell research

authors： Zheng Q,Hou J,Zhou Y,Yang Y,Xie B,Cao X

更新日期：2015-10-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant innate immune responses. In a genetic screen to search for mutants with constitutive defense responses, we identified multiple alleles of mpk4 and mekk1 that exhibit cell death and constitutive defense responses. Bimolecular fluo...

journal_title：Cell research

authors： Gao M,Liu J,Bi D,Zhang Z,Cheng F,Chen S,Zhang Y

更新日期：2008-12-01 00:00:00

abstract：:Amyloid-beta (Abeta) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated by beta-secretase- and gamma-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic protease, beta -site APP cleavage enzyme (BACE), has been identified as the main ...

journal_title：Cell research

authors： Zou L,Wang Z,Shen L,Bao GB,Wang T,Kang JH,Pei G

更新日期：2007-05-01 00:00:00

abstract：:The nucleotide sequence deduced from the amino acid sequence of the scorpion insectotoxin AaIT was chemically synthesized and was expressed in Escherichia coli. The authenticity of this in vitro expressed peptide was confirmed by N-terminal peptide sequencing. Two groups of bioassays, artificial diet incorporation ass...

journal_title：Cell research

authors： Ji SJ,Liu F,Li EQ,Zhu YX

更新日期：2002-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the microenvironment contributes to NPC progression and immune evasion remains unclear. Here we performed single-cell RNA sequencing on ~104,000 cells from...

journal_title：Cell research

authors： Jin S,Li R,Chen MY,Yu C,Tang LQ,Liu YM,Li JP,Liu YN,Luo YL,Zhao Y,Zhang Y,Xia TL,Liu SX,Liu Q,Wang GN,You R,Peng JY,Li J,Han F,Wang J,Chen QY,Zhang L,Mai HQ,Gewurz BE,Zhao B,Young LS,Zhong Q,Bai F,

更新日期：2020-11-01 00:00:00

abstract：:Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feedin...

journal_title：Cell research

authors： Zhou Z,Li X,Liu J,Dong L,Chen Q,Liu J,Kong H,Zhang Q,Qi X,Hou D,Zhang L,Zhang G,Liu Y,Zhang Y,Li J,Wang J,Chen X,Wang H,Zhang J,Chen H,Zen K,Zhang CY

更新日期：2015-01-01 00:00:00