Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27.

abstract：:Macrophages are important innate immune cells with functions in tissue repair and remodeling, induction and resolution of inflammation, as well as elimination of invading pathogens. In a recent study, Schmidt and colleagues describe the open epigenetic landscape of the human inflammatory macrophages, and the transcrip...

journal_title：Cell research

authors： Netea MG,Joosten LA

更新日期：2016-02-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a core component of raptor-mTOR (mTORC1) and rictor-mTOR (mTORC2) complexes that control diverse cellular processes. Both mTORC1 and mTORC2 regulate several elements downstream of type I insulin-like growth factor receptor (IGF-IR) and insulin receptor (InsR). However, it is unk...

journal_title：Cell research

authors： Yin Y,Hua H,Li M,Liu S,Kong Q,Shao T,Wang J,Luo Y,Wang Q,Luo T,Jiang Y

更新日期：2016-01-01 00:00:00

abstract：:Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...

journal_title：Cell research

authors： Achilleos A,Trainor PA

更新日期：2012-02-01 00:00:00

abstract：:Brassinosteroids (BRs) are essential steroid hormones that have crucial roles in plant growth and development. BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1). In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl te...

journal_title：Cell research

authors： Wang J,Jiang J,Wang J,Chen L,Fan SL,Wu JW,Wang X,Wang ZX

更新日期：2014-11-01 00:00:00

abstract：:Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembra...

journal_title：Cell research

authors： Wang Q,Teng J,Shen B,Zhang W,Guo Y,Su X,Zhang C,Yu AC,Chen J

更新日期：2010-06-01 00:00:00

abstract：:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...

journal_title：Cell research

authors： Li W,Jiang K,Wei W,Shi Y,Ding S

更新日期：2013-01-01 00:00:00

abstract：:MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Micr...

journal_title：Cell research

authors： Wang F,Song W,Zhao H,Ma Y,Li Y,Zhai D,Pi J,Si Y,Xu J,Dong L,Su R,Zhang M,Zhu Y,Ren X,Miao F,Liu W,Li F,Zhang J,He A,Shan G,Hui J,Wang L,Yu J

更新日期：2017-03-01 00:00:00

abstract：:While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation...

journal_title：Cell research

authors： Covarrubias A,Byles V,Horng T

更新日期：2013-08-01 00:00:00

abstract：:Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought that the early antivir...

journal_title：Cell research

authors： Fink K,Martin L,Mukawera E,Chartier S,De Deken X,Brochiero E,Miot F,Grandvaux N

更新日期：2013-05-01 00:00:00

abstract：:The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interaction between Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showed Ese-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by a...

journal_title：Cell research

authors： Yaniw D,Hu J

更新日期：2005-06-01 00:00:00

abstract：:DNA methylation and demethylation regulate many crucial biological processes in mammals and are linked to many diseases. Active DNA demethylation is believed to be catalyzed by TET proteins and a putative DNA decarboxylase that may share some similarities in sequence, structure and catalytic mechanism with isoorotate ...

journal_title：Cell research

authors： Xu S,Li W,Zhu J,Wang R,Li Z,Xu GL,Ding J

更新日期：2013-11-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) was originally recognized for its ability to promote survival of midbrain dopaminergic neurons, but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations, including motor neurons, sympathetic neurons, sensory...

journal_title：Cell research

authors： Jiao L,Zhang Y,Hu C,Wang YG,Huang A,He C

更新日期：2011-02-01 00:00:00

abstract：:The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of b...

journal_title：Cell research

authors： Yang M,Yuan S,Huang S,Li J,Xu L,Huang H,Tao X,Peng J,Xu A

更新日期：2011-10-01 00:00:00

abstract：:Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors. More recently,...

journal_title：Cell research

authors： Clément JF,Meloche S,Servant MJ

更新日期：2008-09-01 00:00:00

abstract：:Although VEGFR-3 deficiency disrupts blood vascular development during early embryogenesis, the underlying mechanism was not clear. To characterize its function in angiogenesis and lymphangiogenesis, we employed two genetically modified mouse models in this study, targeting the coding region for the ligand-binding dom...

journal_title：Cell research

authors： Zhang L,Zhou F,Han W,Shen B,Luo J,Shibuya M,He Y

更新日期：2010-12-01 00:00:00

abstract：:The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

journal_title：Cell research

authors： Xu H,Yi BA,Chien KR

更新日期：2012-11-01 00:00:00

abstract：:There is strong relationship between melanocortin-1 receptor (MC1R) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val6...

journal_title：Cell research

authors： Peng S,Lu XM,Luo HR,Xiang-Yu JG,Zhang YP

更新日期：2001-03-01 00:00:00

abstract：:The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...

journal_title：Cell research

authors： Hou T,Zhang R,Jian C,Ding W,Wang Y,Ling S,Ma Q,Hu X,Cheng H,Wang X

更新日期：2019-09-01 00:00:00

abstract：:Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...

journal_title：Cell research

authors： Gan Z,Fu T,Kelly DP,Vega RB

更新日期：2018-10-01 00:00:00

abstract：:The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin...

journal_title：Cell research

authors： Han JD

更新日期：2008-02-01 00:00:00

abstract：:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after ...

journal_title：Cell research

authors： Ohsumi Y

更新日期：2014-01-01 00:00:00

abstract：:The rice Eui (ELONGATED UPPERMOST INTERNODE) gene encodes a cytochrome P450 monooxygenase that deactivates bioactive gibberellins (GAs). In this study, we investigated controlled expression of the Eui gene and its role in plant development. We found that Eui was differentially induced by exogenous GAs and that the Eui...

journal_title：Cell research

authors： Zhang Y,Zhu Y,Peng Y,Yan D,Li Q,Wang J,Wang L,He Z

更新日期：2008-03-01 00:00:00

abstract：:Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial c...

journal_title：Cell research

authors： Kang Y,Wang F,Feng J,Yang D,Yang X,Yan X

更新日期：2006-03-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive oxygen species. In addition, they are commonly generated during V(D)J recombination, an essential aspect of the developing immune system. Failure to effectively repair these DSBs can result in chromosome breakage, cell death, on...

journal_title：Cell research

authors： Weterings E,Chen DJ

更新日期：2008-01-01 00:00:00

abstract：:Human cytosolic NADP-IDH (IDH1) has recently been found to be involved in tumorigenesis. Notably, the tumor-derived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function...

journal_title：Cell research

authors： Yang B,Zhong C,Peng Y,Lai Z,Ding J

更新日期：2010-11-01 00:00:00

abstract：:A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...

journal_title：Cell research

authors： Xia HC,Li F,Li Z,Zhang ZC

更新日期：2003-10-01 00:00:00

abstract：:Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...

journal_title：Cell research

authors： Schneider T,Bindereif A

更新日期：2017-06-01 00:00:00

abstract：:While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this p...

journal_title：Cell research

authors： Kong LW,Ding XY,Kitani H,Shiurba R,Jing NH

更新日期：1999-12-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report ...

journal_title：Cell research

authors： Zhao B,Zhang W,Cun Y,Li J,Liu Y,Gao J,Zhu H,Zhou H,Zhang R,Zheng P

更新日期：2018-01-01 00:00:00

abstract：:The aneuploid with isochromosome or telochromosome is ideal material for exploring the position of centromere in lingkage map. For obtaining these aneuploids in rice, the primary trisomics from triplo-1 to triplo-12 and the aneuploids derived from a triploid of indica rice variety Zhongxian 3037 were carefully investi...

journal_title：Cell research

authors： Cheng ZK,Yu HX,Yan CJ,Zhu LH,Gu MH

更新日期：1997-06-01 00:00:00