Abstract：
:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after the discovery of lysosomes by de Duve, electron microscopy revealed autophagy as a means of delivering intracellular components to the lysosome. For a long time after the discovery of autophagy, studies failed to yield any significant advances at a molecular level in our understanding of this fundamental pathway of degradation. The first breakthrough was made in the early 1990s, as autophagy was discovered in yeast subjected to starvation by microscopic observation. Next, a genetic effort to address the poorly understood problem of autophagy led to the discovery of many autophagy-defective mutants. Subsequent identification of autophagy-related genes in yeast revealed unique sets of molecules involved in membrane dynamics during autophagy. ATG homologs were subsequently found in various organisms, indicating that the fundamental mechanism of autophagy is well conserved among eukaryotes. These findings brought revolutionary changes to research in this field. For instance, the last 10 years have seen remarkable progress in our understanding of autophagy, not only in terms of the molecular mechanisms of autophagy, but also with regard to its broad physiological roles and relevance to health and disease. Now our knowledge of autophagy is dramatically expanding day by day. Here, the historical landmarks underpinning the explosion of autophagy research are described with a particular focus on the contribution of yeast as a model organism.
journal_name
Cell Resjournal_title
Cell researchauthors
Ohsumi Ydoi
10.1038/cr.2013.169subject
Has Abstractpub_date
2014-01-01 00:00:00pages
9-23issue
1eissn
1001-0602issn
1748-7838pii
cr2013169journal_volume
24pub_type
历史文章,杂志文章,评审相关文献
CELL RESEARCH文献大全abstract：:It was the first time demonstrated by us that the number of newborn neurons was increased after making lesion in forebrain of adult ring dove (Streptopelia risoria) by means of autoradiography and immunohistochemistry. Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrol...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.1998.15
更新日期：1998-06-01 00:00:00
abstract：:Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-019-0153-8
更新日期：2019-04-01 00:00:00
abstract：:We found T-type calcium channel blocker Ni2+ can efficiently induce the formation of cement gland in Xenopus laevis animal cap explants. Another T-type specific calcium channel blocker Amiloride can also induce the formation of cement gland, while L-type specific calcium channel blocker Nifedipine has no inductive eff...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290007
更新日期：1999-03-01 00:00:00
abstract：:There is strong relationship between melanocortin-1 receptor (MC1R) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val6...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290070
更新日期：2001-03-01 00:00:00
abstract：:DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site thr...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2014.13
更新日期：2014-03-01 00:00:00
abstract：:Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, wher...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2011.56
更新日期：2011-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Cell research
pub_type： 已发布勘误
doi：10.1038/s41422-019-0262-4
更新日期：2020-02-01 00:00:00
abstract：:New plant type (NPT) or ideal plant architecture (IPA) is an attractive way of increasing yield potential by promoting high resource use efficiency combined with better lodging resistance. In a recent paper in Cell Research, Wang et al. describe how a QTL they identified could bring about the desired NPT architecture ...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2017.115
更新日期：2017-10-01 00:00:00
abstract：:While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2013.88
更新日期：2013-08-01 00:00:00
abstract：:Cellular biological activities are tightly controlled by intracellular signaling processes initiated by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups from phosphorylated signaling molecules, play equally important tyrosine roles as protein tyrosine kinases in signal transduction. ...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/sj.cr.7290055
更新日期：2000-12-01 00:00:00
abstract：:Leaf morphogenesis requires the establishment of adaxial-abaxial polarity after primordium initiation from the shoot apical meristem (SAM). Several families of transcription factors are known to play critical roles in promoting adaxial or abaxial leaf fate. Recently, post-transcriptional gene silencing pathways have b...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2007.45
更新日期：2007-06-01 00:00:00
abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2008.83
更新日期：2008-08-01 00:00:00
abstract：:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2012.182
更新日期：2013-01-01 00:00:00
abstract：:Human polymorphonuclear leukocytes (PMN) have been reported to completely lack of DNA-dependent protein kinase (DNA-PK) which is composed of Ku protein and the catalytic subunit DNA-PKcs, needed for nonhomologous end-joining (NHEJ) of DNA double-strand breaks. Promyelocytic HL-60 cells express a variant form of Ku res...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290233
更新日期：2004-08-01 00:00:00
abstract：:The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be converted to liver progenitor-like cel...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-018-0103-x
更新日期：2019-01-01 00:00:00
abstract：:The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2016.10
更新日期：2016-03-01 00:00:00
abstract：:The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-019-0208-x
更新日期：2019-09-01 00:00:00
abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2015.3
更新日期：2015-02-01 00:00:00
abstract：:The nucleotide sequence deduced from the amino acid sequence of the scorpion insectotoxin AaIT was chemically synthesized and was expressed in Escherichia coli. The authenticity of this in vitro expressed peptide was confirmed by N-terminal peptide sequencing. Two groups of bioassays, artificial diet incorporation ass...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/sj.cr.7290120
更新日期：2002-06-01 00:00:00
abstract：:Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine c...
journal_title：Cell research
pub_type： 评论,杂志文章
doi：10.1038/cr.2014.110
更新日期：2014-09-01 00:00:00
abstract：:Aging is associated with many complex diseases. Reliable prediction of the aging process is important for assessing the risks of aging-associated diseases. However, despite intense research, so far there is no reliable aging marker. Here we addressed this problem by examining whether human 3D facial imaging features c...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2015.36
更新日期：2015-05-01 00:00:00
abstract：:The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identified in the basal chordate amphioxus, links this pathway to invertebrates. The protein architecture of b...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2011.156
更新日期：2011-10-01 00:00:00
abstract：:Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ porta...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/s41422-020-0363-0
更新日期：2020-10-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) was originally recognized for its ability to promote survival of midbrain dopaminergic neurons, but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations, including motor neurons, sympathetic neurons, sensory...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2010.139
更新日期：2011-02-01 00:00:00
abstract：:Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report ...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2017.139
更新日期：2018-01-01 00:00:00
abstract：:Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors. More recently,...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/cr.2008.273
更新日期：2008-09-01 00:00:00
abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/sj.cr.7290094
更新日期：2001-12-01 00:00:00
abstract：:The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammali...
journal_title：Cell research
pub_type： 杂志文章
doi：10.1038/cr.2011.40
更新日期：2011-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Cell research
pub_type： 已发布勘误
doi：10.1038/s41422-020-0311-z
更新日期：2020-06-01 00:00:00
abstract：:The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insigh...
journal_title：Cell research
pub_type： 杂志文章,评审
doi：10.1038/sj.cr.7290208
更新日期：2004-04-01 00:00:00
