Abstract:
:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipulate stem cell fates is essential to understand the basic mechanisms of stem cell biology, and to translate stem cells into regenerative medicine. Chemical approaches have recently provided a number of small molecules that can be used to control cell self-renewal, lineage differentiation, reprogramming and regeneration. These chemical modulators have been proven to be versatile tools for probing stem cell biology and manipulating cell fates toward desired outcomes. Ultimately, this strategy is promising to be a new frontier for drug development aimed at endogenous stem cell modulation.
journal_name
Cell Resjournal_title
Cell researchauthors
Li W,Jiang K,Wei W,Shi Y,Ding Sdoi
10.1038/cr.2012.182subject
Has Abstractpub_date
2013-01-01 00:00:00pages
81-91issue
1eissn
1001-0602issn
1748-7838pii
cr2012182journal_volume
23pub_type
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