A novel in vitro system for gamete fusion in maize.

abstract：:A wide variety of neurons and glial cells differentiate from common precursor cells in the developing nervous system. During this process, Notch-mediated cell-cell interaction is essential for maintenance of dividing cells and subsequent generation of cell type diversity. Activation of Notch inhibits cellular differen...

journal_title：Cell research

authors： Kageyama R,Ohtsuka T

更新日期：1999-09-01 00:00:00

abstract：:The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammali...

journal_title：Cell research

authors： Simonet T,Zaragosi LE,Philippe C,Lebrigand K,Schouteden C,Augereau A,Bauwens S,Ye J,Santagostino M,Giulotto E,Magdinier F,Horard B,Barbry P,Waldmann R,Gilson E

更新日期：2011-07-01 00:00:00

abstract：:The non-canonical inflammasome triggers host cell death and inflammation upon recognition of cytosolic LPS. A recent report in Cell now shows that Outer Membrane Vesicles (OMVs) of extracellular Gram-negative bacteria can deliver LPS into the host cell cytosol. ...

journal_title：Cell research

authors： Broz P

更新日期：2016-08-01 00:00:00

abstract：:Elimination of misfolded proteins of the endoplasmic reticulum (ER) requires their retrotranslocation from the ER to the cytosol via membrane-bound ubiquitin ligase complexes. Baldridge and Rapoport now reconstitute a key step of retrotranslocation, demonstrating a protein conduit gated by ubiquitination. ...

journal_title：Cell research

authors： Zhang T,Ye Y

更新日期：2016-10-01 00:00:00

abstract：:Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further...

journal_title：Cell research

authors： Ma X,Huang J,Yang L,Yang Y,Li W,Xue L

更新日期：2012-02-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00

abstract：:A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...

journal_title：Cell research

authors： Xia HC,Li F,Li Z,Zhang ZC

更新日期：2003-10-01 00:00:00

abstract：:KDR (kinase insert domain receptor) phosphorylation induces several effects which lead eventually to cell proliferation and survival. The precise mechanisms by which KDR, once it is activated, communicates with the nucleus are starting to be understood but have not yet been completely unravelled. Two in vitro studies ...

journal_title：Cell research

authors： Blazquez C,Cook N,Micklem K,Harris AL,Gatter KC,Pezzella F

更新日期：2006-01-01 00:00:00

abstract：:Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here,...

journal_title：Cell research

authors： Zheng Q,Hou J,Zhou Y,Yang Y,Xie B,Cao X

更新日期：2015-10-01 00:00:00

abstract：:Human gastric cancer MKN-45 cells were transfected with pULB 3238, a plasmid carrying MVMp NS-1 gene with its original P4 promoter replaced by the glucocorticoid inducible promoter MMTV-LTR. After the integration and expression of NS-1 gene, some of the transfectants died, while others remained alive, but the growth f...

journal_title：Cell research

authors： Shen XZ,Tsung HC,Yang YW,Yang QH,Xiao SD

更新日期：1997-12-01 00:00:00

abstract：:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after ...

journal_title：Cell research

authors： Ohsumi Y

更新日期：2014-01-01 00:00:00

abstract：:It is well documented that g-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosome reaction induced by GABA and progesterone. GABA transporter I (GAT1) also existed in testis and sperm, bu...

journal_title：Cell research

authors： Hu JH,Zhang JF,Ma YH,Jiang J,Yang N,Li XB,Yu Chi ZG,Fei J,Guo LH

更新日期：2004-02-01 00:00:00

abstract：:Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, wher...

journal_title：Cell research

authors： Bai L,Deng X,Li J,Wang M,Li Q,An W,A D,Cong YS

更新日期：2011-07-01 00:00:00

abstract：:It was the first time demonstrated by us that the number of newborn neurons was increased after making lesion in forebrain of adult ring dove (Streptopelia risoria) by means of autoradiography and immunohistochemistry. Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrol...

journal_title：Cell research

authors： Zuo MX

更新日期：1998-06-01 00:00:00

abstract：:The nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR). Here we present a single-particle cryo-electron microscopy (cryo-EM) structure of the CR from Xenopus laevis NPC at average resolutions of 5.5-7.9 Å, with loca...

journal_title：Cell research

authors： Huang G,Zhang Y,Zhu X,Zeng C,Wang Q,Zhou Q,Tao Q,Liu M,Lei J,Yan C,Shi Y

更新日期：2020-06-01 00:00:00

abstract：:A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin....

journal_title：Cell research

authors： Odoardi F,Neuhuber W,Flügel A

更新日期：2014-09-01 00:00:00

abstract：:Leptin is the protein product encoded by the obese (ob) gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic, and diabetic. Since the cloning of leptin in 1994, our knowledge in body ...

journal_title：Cell research

authors： Huang L,Li C

更新日期：2000-06-01 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aerugi...

journal_title：Cell research

authors： Wiedenheft B,Bondy-Denomy J

更新日期：2017-02-01 00:00:00

abstract：:Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellul...

journal_title：Cell research

authors： Sengupta A,Banerjee B,Tyagi RK,Datta K

更新日期：2005-03-01 00:00:00

abstract：:Cotton fibers elongate rapidly after initiation of elongation, eventually leading to the deposit of a large amount of cellulose. To reveal features of cotton fiber cells at the fast elongation and the secondary cell wall synthesis stages, we compared the respective transcriptomes and metabolite profiles. Comparative a...

journal_title：Cell research

authors： Gou JY,Wang LJ,Chen SP,Hu WL,Chen XY

更新日期：2007-05-01 00:00:00

abstract：:During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The mechanisms underlying meiotic chromosome synapsis, DSB repair and apoptosis are not fully understood. Here...

journal_title：Cell research

authors： Xu J,Sun X,Jing Y,Wang M,Liu K,Jian Y,Yang M,Cheng Z,Yang C

更新日期：2012-05-01 00:00:00

abstract：:In quorum sensing (QS) process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 (AI-2), a QS signaling molecule proposed to be involved in interspecies communication, is produced by many species of gram-negative ...

journal_title：Cell research

authors： Xue T,Zhao L,Sun H,Zhou X,Sun B

更新日期：2009-11-01 00:00:00

abstract：:α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) (hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination ...

journal_title：Cell research

authors： Liao S,Rajendraprasad G,Wang N,Eibes S,Gao J,Yu H,Wu G,Tu X,Huang H,Barisic M,Xu C

更新日期：2019-07-01 00:00:00

abstract：:Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an under...

journal_title：Cell research

authors： Figeys D

更新日期：2008-07-01 00:00:00

abstract：:Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feedin...

journal_title：Cell research

authors： Zhou Z,Li X,Liu J,Dong L,Chen Q,Liu J,Kong H,Zhang Q,Qi X,Hou D,Zhang L,Zhang G,Liu Y,Zhang Y,Li J,Wang J,Chen X,Wang H,Zhang J,Chen H,Zen K,Zhang CY

更新日期：2015-01-01 00:00:00

abstract：:Our previous study showed that hydroxyurea (Hu) could induce HEL cells to express human beta-globin gene. However the molecular mechanisms by which the expression of beta-globin gene is activated and regulated are poorly understood. Here we show that the binding patterns between the core DNA sequences (HS2 core sequen...

journal_title：Cell research

authors： Zhang SB,Qian RL

更新日期：2002-12-01 00:00:00

abstract：:Heterotrimeric G proteins are known to function as messengers in numerous signal transduction pathways. The null mutation of RGA (rice heterotrimeric G protein alpha subunit), which encodes the alpha subunit of heterotrimeric G protein in rice, causes severe dwarfism and reduced responsiveness to gibberellic acid in r...

journal_title：Cell research

authors： Wang L,Xu YY,Ma QB,Li D,Xu ZH,Chong K

更新日期：2006-12-01 00:00:00

abstract：:Leaf morphogenesis requires the establishment of adaxial-abaxial polarity after primordium initiation from the shoot apical meristem (SAM). Several families of transcription factors are known to play critical roles in promoting adaxial or abaxial leaf fate. Recently, post-transcriptional gene silencing pathways have b...

journal_title：Cell research

authors： Xu L,Yang L,Huang H

更新日期：2007-06-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant innate immune responses. In a genetic screen to search for mutants with constitutive defense responses, we identified multiple alleles of mpk4 and mekk1 that exhibit cell death and constitutive defense responses. Bimolecular fluo...

journal_title：Cell research

authors： Gao M,Liu J,Bi D,Zhang Z,Cheng F,Chen S,Zhang Y

更新日期：2008-12-01 00:00:00