Abstract:
:Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, whereas reduced PTRF expression extended the cellular replicative lifespan. Interestingly, we found that PTRF localized primarily to the nuclei of young and quiescent WI-38 human fibroblasts, but translocated to the cytosol and plasma membrane during cellular senescence. Furthermore, electron microscopic analysis demonstrated an increased number of caveolar structures in senescent and PTRF-transfected WI-38 cells. Our data suggest that the role of PTRF in cellular senescence is dependent on its targeting to caveolae and its interaction with caveolin-1, which appeared to be regulated by the phosphorylation of PTRF. Taken together, our findings identify PTRF as a novel regulator of cellular senescence that acts through the p53/p21 and caveolar pathways.
journal_name
Cell Resjournal_title
Cell researchauthors
Bai L,Deng X,Li J,Wang M,Li Q,An W,A D,Cong YSdoi
10.1038/cr.2011.56subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1088-101issue
7eissn
1001-0602issn
1748-7838pii
cr201156journal_volume
21pub_type
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