A preliminary analysis of antineoplastic activity of parvovirus MVMp NS-1 proteins.

abstract：:In the present article, we report that DR4 or DR5 overexpression dramatically activates the release of the inflammatory cytokines IL-8, TNF-alpha, CCL20, MIP-2 and MIP-1beta in an NF-kappaB-dependent manner in 293T, MDA-MB-231 and HCT-116 cells. We showed that death receptor-mediated signals were extracellular domain-...

journal_title：Cell research

authors： Tang W,Wang W,Zhang Y,Liu S,Liu Y,Zheng D

更新日期：2009-06-01 00:00:00

abstract：:The full-length cDNA of Pinellia ternata agglutinin (PTA) was cloned from inflorescences using RACE-PCR. Through comparative analysis of PTA gene (pta) and its deduced amino acid sequence with those of other Araceae species, pta was found to encode a precursor lectin with signal peptide and to have extensive homology ...

journal_title：Cell research

authors： Yao JH,Zhao XY,Liao ZH,Lin J,Chen ZH,Chen F,Song J,Sun XF,Tang KX

更新日期：2003-08-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00

abstract：:It was the first time demonstrated by us that the number of newborn neurons was increased after making lesion in forebrain of adult ring dove (Streptopelia risoria) by means of autoradiography and immunohistochemistry. Neurogenesis in the adult avian is restricted to the telencephalon. In doves with bilateral electrol...

journal_title：Cell research

authors： Zuo MX

更新日期：1998-06-01 00:00:00

abstract：:MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Micr...

journal_title：Cell research

authors： Wang F,Song W,Zhao H,Ma Y,Li Y,Zhai D,Pi J,Si Y,Xu J,Dong L,Su R,Zhang M,Zhu Y,Ren X,Miao F,Liu W,Li F,Zhang J,He A,Shan G,Hui J,Wang L,Yu J

更新日期：2017-03-01 00:00:00

abstract：:Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here,...

journal_title：Cell research

authors： Zheng Q,Hou J,Zhou Y,Yang Y,Xie B,Cao X

更新日期：2015-10-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) participate in the processes of postnatal neovascularization and re-endothelialization in response to tissue ischemia and endothelial injury. The level of EPCs present has been found to be directly associated with the outcome of cardiovascular diseases, and could be regulated by sti...

journal_title：Cell research

authors： Yin T,Ma X,Zhao L,Cheng K,Wang H

更新日期：2008-07-01 00:00:00

abstract：:α-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) (hereafter denoted as SVBP-VASH1) that catalyzes the detyrosination ...

journal_title：Cell research

authors： Liao S,Rajendraprasad G,Wang N,Eibes S,Gao J,Yu H,Wu G,Tu X,Huang H,Barisic M,Xu C

更新日期：2019-07-01 00:00:00

abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...

journal_title：Cell research

authors： Wu FS

更新日期：2005-11-01 00:00:00

abstract：:In 2006, the "wall came down" that limited the experimental conversion of differentiated cells into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a handful of transcription factors (Oct4, Sox2, Klf4 and c-Myc) can convert a differentiated cell back to pluripotency over the course ...

journal_title：Cell research

authors： Papp B,Plath K

更新日期：2011-03-01 00:00:00

abstract：:Amyloid-beta (Abeta) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated by beta-secretase- and gamma-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic protease, beta -site APP cleavage enzyme (BACE), has been identified as the main ...

journal_title：Cell research

authors： Zou L,Wang Z,Shen L,Bao GB,Wang T,Kang JH,Pei G

更新日期：2007-05-01 00:00:00

abstract：:Wor1 (white-opaque switching regulator 1) is a master regulator of the white-opaque switching in Candida albicans, an opportunistic human fungal pathogen, and is associated with its pathogenicity and commensality. Wor1 contains a conserved DNA-binding region at the N-terminus, consisting of two conserved segments (WOP...

journal_title：Cell research

authors： Zhang S,Zhang T,Yan M,Ding J,Chen J

更新日期：2014-09-01 00:00:00

abstract：:Efficient generation of functional human vascular endothelial cells and smooth muscle cells from pluripotent stem cells is an extensively studied topic and of great interest in the stem cell field. Though thought to be technically complex and difficult, substantial progress has been made towards this direction. Here w...

journal_title：Cell research

authors： Yi F,Qu J,Liu GH,Izpisua Belmonte JC

更新日期：2013-01-01 00:00:00

abstract：:The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here we demonstrate that ML...

journal_title：Cell research

authors： Xia B,Fang S,Chen X,Hu H,Chen P,Wang H,Gao Z

更新日期：2016-05-01 00:00:00

abstract：:This article profiles current status of spread and control of HIV/AIDS in China. China has a significant population of MSM (men who have sex with men) and they have been becoming very much alive in many ways since 1990s due to recent social changes. Some surveys indicate that great many of MSM are engaged in high-risk...

journal_title：Cell research

authors： Zhang BC,Chu QS

更新日期：2005-11-01 00:00:00

abstract：:Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feedin...

journal_title：Cell research

authors： Zhou Z,Li X,Liu J,Dong L,Chen Q,Liu J,Kong H,Zhang Q,Qi X,Hou D,Zhang L,Zhang G,Liu Y,Zhang Y,Li J,Wang J,Chen X,Wang H,Zhang J,Chen H,Zen K,Zhang CY

更新日期：2015-01-01 00:00:00

abstract：:Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long lasting question whether some of the somatic cells retains totipotency was answered by the cloning of Dolly at the end of the 20th century. The dawn of the 21st has brought forward great expectations in harnessing the power ...

journal_title：Cell research

authors： Pan GJ,Chang ZY,Schöler HR,Pei D

更新日期：2002-12-01 00:00:00

abstract：:The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be converted to liver progenitor-like cel...

journal_title：Cell research

authors： Fu GB,Huang WJ,Zeng M,Zhou X,Wu HP,Liu CC,Wu H,Weng J,Zhang HD,Cai YC,Ashton C,Ding M,Tang D,Zhang BH,Gao Y,Yu WF,Zhai B,He ZY,Wang HY,Yan HX

更新日期：2019-01-01 00:00:00

abstract：:Human cytosolic NADP-IDH (IDH1) has recently been found to be involved in tumorigenesis. Notably, the tumor-derived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function...

journal_title：Cell research

authors： Yang B,Zhong C,Peng Y,Lai Z,Ding J

更新日期：2010-11-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder often considered to be the third most common muscular dystrophy. Deletions reducing the copy number of the D4Z4 repeat in the distal end of the 4q arm are the main genetic cause of the disease. The recently highlighted research has identified a ...

journal_title：Cell research

authors： Vizoso M,Esteller M

更新日期：2012-10-01 00:00:00

abstract：:The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein)-retinoic acid receptor alpha. The PML protein localises to a subnuclear structure called the PML nuclear domain (PML-ND), of which PML is the...

journal_title：Cell research

authors： Salomoni P,Ferguson BJ,Wyllie AH,Rich T

更新日期：2008-06-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:Brassinosteroids (BRs) are essential steroid hormones that have crucial roles in plant growth and development. BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1). In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl te...

journal_title：Cell research

authors： Wang J,Jiang J,Wang J,Chen L,Fan SL,Wu JW,Wang X,Wang ZX

更新日期：2014-11-01 00:00:00

abstract：:Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy, particularly autophagic degradation of cellular iron storage proteins (a process known as ferritinophagy), in ferroptosis. ...

journal_title：Cell research

authors： Gao M,Monian P,Pan Q,Zhang W,Xiang J,Jiang X

更新日期：2016-09-01 00:00:00

abstract：:A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin....

journal_title：Cell research

authors： Odoardi F,Neuhuber W,Flügel A

更新日期：2014-09-01 00:00:00

abstract：:It is well documented that g-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABAA and GABAB receptors were present in testis and sperm, and might mediate the acrosome reaction induced by GABA and progesterone. GABA transporter I (GAT1) also existed in testis and sperm, bu...

journal_title：Cell research

authors： Hu JH,Zhang JF,Ma YH,Jiang J,Yang N,Li XB,Yu Chi ZG,Fei J,Guo LH

更新日期：2004-02-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00

abstract：:Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous circRNAs coding for proteins. ...

journal_title：Cell research

authors： Schneider T,Bindereif A

更新日期：2017-06-01 00:00:00

abstract：:While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this p...

journal_title：Cell research

authors： Kong LW,Ding XY,Kitani H,Shiurba R,Jing NH

更新日期：1999-12-01 00:00:00

abstract：:In order to analyze the mechanism of immuno-modulation by LPS on murine peritoneal suppressor macrophages, we have, using RNase protection assay, checked the changes of mRNA expression pattern of several cytokine genes during the immuno-modulation. It has been found that, after treating peritoneal suppressor macrophag...

journal_title：Cell research

authors： Feng WG,Chang ZL

更新日期：1998-12-01 00:00:00