Abstract:
:The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein)-retinoic acid receptor alpha. The PML protein localises to a subnuclear structure called the PML nuclear domain (PML-ND), of which PML is the essential structural component. In APL, PML-NDs are disrupted, thus implicating these structures in the pathogenesis of this leukaemia. Unexpectedly, recent studies indicate that PML and the PML-ND play a tumour suppressive role in several different types of human neoplasms in addition to APL. Because of PML's extreme versatility and involvement in multiple cellular pathways, understanding the mechanisms underlying its function, and therefore role in tumour suppression, has been a challenging task. In this review, we attempt to critically appraise the more recent advances in this field and propose new avenues of investigation.
journal_name
Cell Resjournal_title
Cell researchauthors
Salomoni P,Ferguson BJ,Wyllie AH,Rich Tdoi
10.1038/cr.2008.58subject
Has Abstractpub_date
2008-06-01 00:00:00pages
622-40issue
6eissn
1001-0602issn
1748-7838pii
cr200858journal_volume
18pub_type
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