The presence of ANP in rat peritoneal mast cells.

abstract：:Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fiber of kinetochore. Using immunoelectron microscopy, here we show that TTK is present at the nuclear pore adjace...

journal_title：Cell research

authors： Dou Z,Sawagechi A,Zhang J,Luo H,Brako L,Yao XB

更新日期：2003-12-01 00:00:00

abstract：:Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable individuals, pSNMs have never been identified at whole-genome scale largely due to technical difficulties an...

journal_title：Cell research

authors： Huang AY,Xu X,Ye AY,Wu Q,Yan L,Zhao B,Yang X,He Y,Wang S,Zhang Z,Gu B,Zhao HQ,Wang M,Gao H,Gao G,Zhang Z,Yang X,Wu X,Zhang Y,Wei L

更新日期：2014-11-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder often considered to be the third most common muscular dystrophy. Deletions reducing the copy number of the D4Z4 repeat in the distal end of the 4q arm are the main genetic cause of the disease. The recently highlighted research has identified a ...

journal_title：Cell research

authors： Vizoso M,Esteller M

更新日期：2012-10-01 00:00:00

abstract：:Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedback loop to promote i...

journal_title：Cell research

authors： Zhou Y,Li M,Xue Y,Li Z,Wen W,Liu X,Ma Y,Zhang L,Shen Z,Cao X

更新日期：2019-08-01 00:00:00

abstract：:By screening tobacco cDNA library with MCK1 as a probe, we isolated a cDNA clone NtCPK5 (accession number AY971376), which encodes a typical calcium-dependent protein kinase. Sequence analyses indicated that NtCPK5 is related to both CPKs and CRKs superfamilies and has all of the three conserved domains of CPKs. The b...

journal_title：Cell research

authors： Wang Y,Zhang M,Ke K,Lu YT

更新日期：2005-08-01 00:00:00

abstract：:The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights...

journal_title：Cell research

authors： Yuan HX,Guan KL

更新日期：2016-03-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:Brassinosteroids (BRs) are essential steroid hormones that have crucial roles in plant growth and development. BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1). In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl te...

journal_title：Cell research

authors： Wang J,Jiang J,Wang J,Chen L,Fan SL,Wu JW,Wang X,Wang ZX

更新日期：2014-11-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) carries out tumor suppressor activity in epithelial and lymphoid cells, whereas telomerase is required for most cancers. Although the molecular mechanisms by which TGF-beta acts as a tumor suppressor are yet to be fully established, a link between TGFb and its tumor suppresso...

journal_title：Cell research

authors： Li H,Xu D,Toh BH,Liu JP

更新日期：2006-02-01 00:00:00

abstract：:Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that...

journal_title：Cell research

authors： Hou P,Yang K,Jia P,Liu L,Lin Y,Li Z,Li J,Chen S,Guo S,Pan J,Wu J,Peng H,Zeng W,Li C,Liu Y,Guo D

更新日期：2021-01-01 00:00:00

abstract：:Calcium-dependent proteolytic calpains are implicated in a variety of physiological processes, as well as pathologies associated with calcium overload. However, the mechanism by which calpain is activated remains elusive since intracellular calcium levels under physiological conditions do not reach the high concentrat...

journal_title：Cell research

authors： Metwally E,Zhao G,Wang Q,Zhang YQ

更新日期：2020-08-26 00:00:00

abstract：:The year of 2013 marked the 50th anniversary of C de Duve's coining of the term "autophagy" for the degradation process of cytoplasmic constituents in the lysosome/vacuole. This year we regretfully lost this great scientist, who contributed much during the early years of research to the field of autophagy. Soon after ...

journal_title：Cell research

authors： Ohsumi Y

更新日期：2014-01-01 00:00:00

abstract：:Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...

journal_title：Cell research

authors： Zhang Q,Meng Y,Zhang L,Chen J,Zhu D

更新日期：2009-03-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in m...

journal_title：Cell research

authors： Wang M,Yang L,Sheng X,Chen W,Tang H,Sheng H,Xi B,Zang YQ

更新日期：2011-09-01 00:00:00

abstract：:The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...

journal_title：Cell research

authors： Zhang Z,Wang M,Xie D,Huang Z,Zhang L,Yang Y,Ma D,Li W,Zhou Q,Yang YG,Wang XJ

更新日期：2018-11-01 00:00:00

abstract：:Wor1 (white-opaque switching regulator 1) is a master regulator of the white-opaque switching in Candida albicans, an opportunistic human fungal pathogen, and is associated with its pathogenicity and commensality. Wor1 contains a conserved DNA-binding region at the N-terminus, consisting of two conserved segments (WOP...

journal_title：Cell research

authors： Zhang S,Zhang T,Yan M,Ding J,Chen J

更新日期：2014-09-01 00:00:00

abstract：:In mice treated with antibiotics to deplete commensal microbiota, there is a significant overhaul of host cellular disposition and function with CX3CR1+ mononuclear phagocytic cells carrying pathogenic and non-pathogenic administered bacteria to the (messenteric lymph node) MLN, resulting in T cell stimulation and IgA...

journal_title：Cell research

authors： Dasgupta S,Kasper DL

更新日期：2013-05-01 00:00:00

abstract：:The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...

journal_title：Cell research

authors： Lv X,Han Z,Chen H,Yang B,Yang X,Xia Y,Pan C,Fu L,Zhang S,Han H,Wu M,Zhou Z,Zhang L,Li L,Wei G,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:Morphologically, caveolae and lipid rafts are two different membrane structures. They are often reported to share similar lipid and protein compositions, and are considered to be two subtypes of membrane lipid microdomains. By modifying sucrose density gradient flotation centrifugation, which is used to isolate lipid ...

journal_title：Cell research

authors： Yao Y,Hong S,Zhou H,Yuan T,Zeng R,Liao K

更新日期：2009-04-01 00:00:00

abstract：:Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors, mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding prot...

journal_title：Cell research

authors： Fan G,Hutnick L

更新日期：2005-04-01 00:00:00

abstract：:Plant responses to developmental and environmental cues are often mediated by calcium (Ca(2+)) signals that are transmitted by diverse calcium sensors. The calcineurin B-like (CBL) protein family represents calcium sensors that decode calcium signals through specific interactions with a group of CBL-interacting protei...

journal_title：Cell research

authors： Tang RJ,Liu H,Yang Y,Yang L,Gao XS,Garcia VJ,Luan S,Zhang HX

更新日期：2012-12-01 00:00:00

abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...

journal_title：Cell research

authors： Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger

更新日期：2015-02-01 00:00:00

abstract：:In the present article, we report that DR4 or DR5 overexpression dramatically activates the release of the inflammatory cytokines IL-8, TNF-alpha, CCL20, MIP-2 and MIP-1beta in an NF-kappaB-dependent manner in 293T, MDA-MB-231 and HCT-116 cells. We showed that death receptor-mediated signals were extracellular domain-...

journal_title：Cell research

authors： Tang W,Wang W,Zhang Y,Liu S,Liu Y,Zheng D

更新日期：2009-06-01 00:00:00

abstract：:Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembra...

journal_title：Cell research

authors： Wang Q,Teng J,Shen B,Zhang W,Guo Y,Su X,Zhang C,Yu AC,Chen J

更新日期：2010-06-01 00:00:00

abstract：:The partitioning-defective 3 (Par3), a key component in the conserved Par3/Par6/aPKC complex, plays fundamental roles in cell polarity. Herein we report the identification of Ku70 and Ku80 as novel Par3-interacting proteins through an in vitro binding assay followed by liquid chromatography-tandem mass spectrometry. K...

journal_title：Cell research

authors： Fang L,Wang Y,Du D,Yang G,Tak Kwok T,Kai Kong S,Chen B,Chen DJ,Chen Z

更新日期：2007-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Wang MS,Thakur M,Peng MS,Jiang Y,Frantz LAF,Li M,Zhang JJ,Wang S,Peters J,Otecko NO,Suwannapoom C,Guo X,Zheng ZQ,Esmailizadeh A,Hirimuthugoda NY,Ashari H,Suladari S,Zein MSA,Kusza S,Sohrabi S,Kharrati-Koopaee H,

更新日期：2020-09-01 00:00:00

abstract：:Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...

journal_title：Cell research

authors： He XB,Yan YC,Li YP,Koide SS

更新日期：2003-04-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00

abstract：:Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial c...

journal_title：Cell research

authors： Kang Y,Wang F,Feng J,Yang D,Yang X,Yan X

更新日期：2006-03-01 00:00:00

abstract：:Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive ...

journal_title：Cell research

authors： Gao R,Liang X,Cheedipudi S,Cordero J,Jiang X,Zhang Q,Caputo L,Günther S,Kuenne C,Ren Y,Bhattacharya S,Yuan X,Barreto G,Chen Y,Braun T,Evans SM,Sun Y,Dobreva G

更新日期：2019-06-01 00:00:00