Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

abstract：:Mitochondria have long been considered to be the powerhouse of the living cell, generating energy in the form of the molecule ATP via the process of oxidative phosphorylation. In the past 20 years, it has been recognised that they also play an important role in the implementation of apoptosis, or programmed cell death...

journal_title：Cell research

authors： Xu W,Charles IG,Moncada S

更新日期：2005-01-01 00:00:00

abstract：:High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...

journal_title：Cell research

authors： Cutri BA,Hime NJ,Nicholls SJ

更新日期：2006-10-01 00:00:00

abstract：:Mechanical deformability is known to increase during cancer progression. Now Ma et al. identify a therapeutic strategy that targets deformable cells by microparticle-based drug delivery. ...

journal_title：Cell research

authors： Hamann J,Overholtzer M

更新日期：2016-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and has been shown to be closely associated with various malignancies. Here, we present a complete atomic model of EBV, including the icosahedral capsid, the dodecameric portal and the capsid-associated tegument complex (CATC). Our in situ porta...

journal_title：Cell research

authors： Li Z,Zhang X,Dong L,Pang J,Xu M,Zhong Q,Zeng MS,Yu X

更新日期：2020-10-01 00:00:00

abstract：:Previously, mouse bone marrow-derived stem cells (MSC) treated with the unspecific DNA methyltransferase inhibitor 5-azacytidine were reported to differentiate into cardiomyocytes. The aim of the present study was to investigate the efficiency of a similar differentiation strategy in human mononuclear cells obtained f...

journal_title：Cell research

authors： Balana B,Nicoletti C,Zahanich I,Graf EM,Christ T,Boxberger S,Ravens U

更新日期：2006-12-01 00:00:00

abstract：:Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited a...

journal_title：Cell research

authors： Hennersdorf F,Florian S,Jakob A,Baumgärtner K,Sonneck K,Nordheim A,Biedermann T,Valent P,Bühring HJ

更新日期：2005-05-01 00:00:00

abstract：:CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

journal_title：Cell research

authors： Wang C,Chen X,Wang Y,Gong J,Hu G

更新日期：2007-04-01 00:00:00

abstract：:LRP16 was previously identified as an estrogen-induced gene in breast cancer cells. The responsiveness of LRP16 to estrogen and its functional effects in endometrial cancer (EC) cells are still unclear. Here, we show that the mRNA level and promoter activity of the LRP16 gene were significantly increased by 17beta-est...

journal_title：Cell research

authors： Meng YG,Han WD,Zhao YL,Huang K,Si YL,Wu ZQ,Mu YM

更新日期：2007-10-01 00:00:00

abstract：:Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical pathway that mediates inflammatory responses, and the non-canonical pathway that is involved in immune cell differentiation and maturation and secondary lymphoid organogenesis. The former is dependent on the IκB kinase adaptor ...

journal_title：Cell research

authors： Shih VF,Tsui R,Caldwell A,Hoffmann A

更新日期：2011-01-01 00:00:00

abstract：:Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here,...

journal_title：Cell research

authors： Zheng Q,Hou J,Zhou Y,Yang Y,Xie B,Cao X

更新日期：2015-10-01 00:00:00

abstract：:The nucleotide sequence deduced from the amino acid sequence of the scorpion insectotoxin AaIT was chemically synthesized and was expressed in Escherichia coli. The authenticity of this in vitro expressed peptide was confirmed by N-terminal peptide sequencing. Two groups of bioassays, artificial diet incorporation ass...

journal_title：Cell research

authors： Ji SJ,Liu F,Li EQ,Zhu YX

更新日期：2002-06-01 00:00:00

abstract：:Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V disrupts the struct...

journal_title：Cell research

authors： Wu B,Hur S

更新日期：2013-06-01 00:00:00

abstract：:A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin....

journal_title：Cell research

authors： Odoardi F,Neuhuber W,Flügel A

更新日期：2014-09-01 00:00:00

abstract：:SRC-3/AIB1 (steroid receptor coactivator 3/amplified in breast cancer 1) is an authentic oncogene that contributes to the development of drug resistance and poor disease-free survival in cancer patients. Autophagy is also an important cell death mechanism that has tumor suppressor function. In this study, we identifie...

journal_title：Cell research

authors： Wu MY,Fu J,Xu J,O'Malley BW,Wu RC

更新日期：2012-06-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:Platelets play an essential role in hemostasis and atherothrombosis. Owing to their short storage time, there is constant demand for this life-saving blood component. In this study, we report that it is feasible to generate functional megakaryocytes and platelets from human embryonic stem cells (hESCs) on a large scal...

journal_title：Cell research

authors： Lu SJ,Li F,Yin H,Feng Q,Kimbrel EA,Hahm E,Thon JN,Wang W,Italiano JE,Cho J,Lanza R

更新日期：2011-03-01 00:00:00

abstract：:This article profiles current status of spread and control of HIV/AIDS in China. China has a significant population of MSM (men who have sex with men) and they have been becoming very much alive in many ways since 1990s due to recent social changes. Some surveys indicate that great many of MSM are engaged in high-risk...

journal_title：Cell research

authors： Zhang BC,Chu QS

更新日期：2005-11-01 00:00:00

abstract：:Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feedin...

journal_title：Cell research

authors： Zhou Z,Li X,Liu J,Dong L,Chen Q,Liu J,Kong H,Zhang Q,Qi X,Hou D,Zhang L,Zhang G,Liu Y,Zhang Y,Li J,Wang J,Chen X,Wang H,Zhang J,Chen H,Zen K,Zhang CY

更新日期：2015-01-01 00:00:00

abstract：:Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find ...

journal_title：Cell research

authors： Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:Craniofacial anomalies (CFAs) characterized by birth defects of skull and facial bones are the most frequent congenital disease. Genomic analysis has identified multiple genes responsible for CFAs; however, the underlying genetic mechanisms for the majority of CFAs remain largely unclear. Our previous study revealed t...

journal_title：Cell research

authors： Shao R,Liu J,Yan G,Zhang J,Han Y,Guo J,Xu Z,Yuan Z,Liu J,Malumbres M,Wan L,Wei W,Zou W

更新日期：2016-06-01 00:00:00

abstract：:Mouse cloning from fertilized eggs can assist development of approaches for the production of "genetically tailored" human embryonic stem (ES) cell lines that are not constrained by the limitations of oocyte availability. However, to date only zygotes have been successfully used as recipients of nuclei from terminally...

journal_title：Cell research

authors： Riaz A,Zhao X,Dai X,Li W,Liu L,Wan H,Yu Y,Wang L,Zhou Q

更新日期：2011-05-01 00:00:00

abstract：:In 2006, the "wall came down" that limited the experimental conversion of differentiated cells into the pluripotent state. In a landmark report, Shinya Yamanaka's group described that a handful of transcription factors (Oct4, Sox2, Klf4 and c-Myc) can convert a differentiated cell back to pluripotency over the course ...

journal_title：Cell research

authors： Papp B,Plath K

更新日期：2011-03-01 00:00:00

abstract：:International non-governmental organizations were among the first international actors that responded to the emergence of AIDS crisis in China. Since 1994, the number of international non-governmental organizations and charitable foundations working in AIDS related issue areas in China has grown steadily and substanti...

journal_title：Cell research

authors： Wu FS

更新日期：2005-11-01 00:00:00

abstract：:Polyamines are implicated in regulating various developmental processes in plants, but their exact roles and how they govern these processes still remain elusive. We report here an Arabidopsis bushy and dwarf mutant, bud2, which results from the complete deletion of one member of the small gene family that encodes S-a...

journal_title：Cell research

authors： Ge C,Cui X,Wang Y,Hu Y,Fu Z,Zhang D,Cheng Z,Li J

更新日期：2006-05-01 00:00:00

abstract：:Postzygotic single-nucleotide mutations (pSNMs) have been studied in cancer and a few other overgrowth human disorders at whole-genome scale and found to play critical roles. However, in clinically unremarkable individuals, pSNMs have never been identified at whole-genome scale largely due to technical difficulties an...

journal_title：Cell research

authors： Huang AY,Xu X,Ye AY,Wu Q,Yan L,Zhao B,Yang X,He Y,Wang S,Zhang Z,Gu B,Zhao HQ,Wang M,Gao H,Gao G,Zhang Z,Yang X,Wu X,Zhang Y,Wei L

更新日期：2014-11-01 00:00:00

abstract：:Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive drug target. Here, we developed a split luciferase complementation-based high-throughput screening assay to id...

journal_title：Cell research

authors： Li Z,Brecher M,Deng YQ,Zhang J,Sakamuru S,Liu B,Huang R,Koetzner CA,Allen CA,Jones SA,Chen H,Zhang NN,Tian M,Gao F,Lin Q,Banavali N,Zhou J,Boles N,Xia M,Kramer LD,Qin CF,Li H

更新日期：2017-08-01 00:00:00

abstract：:The mixed lineage kinase domain-like (MLKL) protein is a key factor in tumor necrosis factor-induced necroptosis. Recent studies on necroptosis execution revealed a commitment role of MLKL in membrane disruption. However, our knowledge of how MLKL functions on membrane remains very limited. Here we demonstrate that ML...

journal_title：Cell research

authors： Xia B,Fang S,Chen X,Hu H,Chen P,Wang H,Gao Z

更新日期：2016-05-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are introduced in cells by ionizing radiation and reactive oxygen species. In addition, they are commonly generated during V(D)J recombination, an essential aspect of the developing immune system. Failure to effectively repair these DSBs can result in chromosome breakage, cell death, on...

journal_title：Cell research

authors： Weterings E,Chen DJ

更新日期：2008-01-01 00:00:00

abstract：:In quorum sensing (QS) process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 (AI-2), a QS signaling molecule proposed to be involved in interspecies communication, is produced by many species of gram-negative ...

journal_title：Cell research

authors： Xue T,Zhao L,Sun H,Zhou X,Sun B

更新日期：2009-11-01 00:00:00

abstract：:MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis. QKI5 recognizes a distal QKI response element and recruits Micr...

journal_title：Cell research

authors： Wang F,Song W,Zhao H,Ma Y,Li Y,Zhai D,Pi J,Si Y,Xu J,Dong L,Su R,Zhang M,Zhu Y,Ren X,Miao F,Liu W,Li F,Zhang J,He A,Shan G,Hui J,Wang L,Yu J

更新日期：2017-03-01 00:00:00