Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium.

abstract：:Heterotrimeric G proteins are known to function as messengers in numerous signal transduction pathways. The null mutation of RGA (rice heterotrimeric G protein alpha subunit), which encodes the alpha subunit of heterotrimeric G protein in rice, causes severe dwarfism and reduced responsiveness to gibberellic acid in r...

journal_title：Cell research

authors： Wang L,Xu YY,Ma QB,Li D,Xu ZH,Chong K

更新日期：2006-12-01 00:00:00

abstract：:Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in ...

journal_title：Cell research

authors： Zhu S,Wang G,Lei X,Flavell RA

更新日期：2016-04-01 00:00:00

abstract：:Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic ...

journal_title：Cell research

authors： Pan T

更新日期：2018-04-01 00:00:00

abstract：:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...

journal_title：Cell research

authors： Li W,Jiang K,Wei W,Shi Y,Ding S

更新日期：2013-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further...

journal_title：Cell research

authors： Ma X,Huang J,Yang L,Yang Y,Li W,Xue L

更新日期：2012-02-01 00:00:00

abstract：:Missense mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) cause the majority of familial and some sporadic forms of Parkinson's disease (PD). The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underlies neurotoxicity, promoting the development of LRRK2 kinase inhibitors as therapeutics. Many potent...

journal_title：Cell research

authors： Schaffner A,Li X,Gomez-Llorente Y,Leandrou E,Memou A,Clemente N,Yao C,Afsari F,Zhi L,Pan N,Morohashi K,Hua X,Zhou MM,Wang C,Zhang H,Chen SG,Elliott CJ,Rideout H,Ubarretxena-Belandia I,Yue Z

更新日期：2019-04-01 00:00:00

abstract：:There are remarkable disparities among patients of different races with prostate cancer; however, the mechanism underlying this difference remains unclear. Here, we present a comprehensive landscape of the transcriptome profiles of 14 primary prostate cancers and their paired normal counterparts from the Chinese popul...

journal_title：Cell research

authors： Ren S,Peng Z,Mao JH,Yu Y,Yin C,Gao X,Cui Z,Zhang J,Yi K,Xu W,Chen C,Wang F,Guo X,Lu J,Yang J,Wei M,Tian Z,Guan Y,Tang L,Xu C,Wang L,Gao X,Tian W,Wang J,Yang H,Wang J,Sun Y

更新日期：2012-05-01 00:00:00

abstract：:One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al...

journal_title：Cell research

authors： Bach I

更新日期：2012-11-01 00:00:00

abstract：:Leptin is the protein product encoded by the obese (ob) gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic, and diabetic. Since the cloning of leptin in 1994, our knowledge in body ...

journal_title：Cell research

authors： Huang L,Li C

更新日期：2000-06-01 00:00:00

abstract：:The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab induces immune-mediated long-term control of metastatic melanoma in a fraction of patients. Although ipilimumab undoubtedly exerts its therapeutic effects via immunostimulation, thus far clinically useful, immunologically relevant biomarkers th...

journal_title：Cell research

authors： Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger

更新日期：2015-02-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Wang MS,Thakur M,Peng MS,Jiang Y,Frantz LAF,Li M,Zhang JJ,Wang S,Peters J,Otecko NO,Suwannapoom C,Guo X,Zheng ZQ,Esmailizadeh A,Hirimuthugoda NY,Ashari H,Suladari S,Zein MSA,Kusza S,Sohrabi S,Kharrati-Koopaee H,

更新日期：2020-09-01 00:00:00

abstract：:A monoclonal antibody, LC-1, recognizing lung cancer associated common antigens was obtained in authors' laboratory. Its single chain Fv fragment (ScFv) named LC-1 ScFv was constructed based on recombinant phage displayed techniques. For expression on cell membrane, LC-1 ScFv was cloned into pDisplay vector, which dir...

journal_title：Cell research

authors： Chen L,Li G,Tang L,Wang J,Ge XR

更新日期：2002-03-01 00:00:00

abstract：:High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...

journal_title：Cell research

authors： Cutri BA,Hime NJ,Nicholls SJ

更新日期：2006-10-01 00:00:00

abstract：:Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that t...

journal_title：Cell research

authors： Yan J,Chen SA,Local A,Liu T,Qiu Y,Dorighi KM,Preissl S,Rivera CM,Wang C,Ye Z,Ge K,Hu M,Wysocka J,Ren B

更新日期：2018-02-01 00:00:00

abstract：:The functional roles of memory B and T lymphocytes underlie the phenomenal success of prophylactic vaccinations, which have decreased morbidities and mortalities from infectious diseases globally over the last 50 years. However, it is becoming increasingly appreciated that memory cells are also capable of mediating th...

journal_title：Cell research

authors： DiSpirito JR,Shen H

更新日期：2010-01-01 00:00:00

abstract：:While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this p...

journal_title：Cell research

authors： Kong LW,Ding XY,Kitani H,Shiurba R,Jing NH

更新日期：1999-12-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammali...

journal_title：Cell research

authors： Simonet T,Zaragosi LE,Philippe C,Lebrigand K,Schouteden C,Augereau A,Bauwens S,Ye J,Santagostino M,Giulotto E,Magdinier F,Horard B,Barbry P,Waldmann R,Gilson E

更新日期：2011-07-01 00:00:00

abstract：:Implantation involves complex signaling networks, which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy. The recent work by Zhang et al. published in Cell Research, identifies the transcriptional regulator, Rbpj, as essential for uterine c...

journal_title：Cell research

authors： Robinson JF,Fisher SJ

更新日期：2014-09-01 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated genes (cas) are essential components of an adaptive immune system that protects bacteria and archaea from viral infection. Now a recent paper published in Cell Research suggests that the Type I-F immune system in Pseudomonas aerugi...

journal_title：Cell research

authors： Wiedenheft B,Bondy-Denomy J

更新日期：2017-02-01 00:00:00

abstract：:Wor1 (white-opaque switching regulator 1) is a master regulator of the white-opaque switching in Candida albicans, an opportunistic human fungal pathogen, and is associated with its pathogenicity and commensality. Wor1 contains a conserved DNA-binding region at the N-terminus, consisting of two conserved segments (WOP...

journal_title：Cell research

authors： Zhang S,Zhang T,Yan M,Ding J,Chen J

更新日期：2014-09-01 00:00:00

abstract：:Airway epithelial cells are key initial innate immune responders in the fight against respiratory viruses, primarily via the secretion of antiviral and proinflammatory cytokines that act in an autocrine/paracrine fashion to trigger the establishment of an antiviral state. It is currently thought that the early antivir...

journal_title：Cell research

authors： Fink K,Martin L,Mukawera E,Chartier S,De Deken X,Brochiero E,Miot F,Grandvaux N

更新日期：2013-05-01 00:00:00

abstract：:Macrophages are important innate immune cells with functions in tissue repair and remodeling, induction and resolution of inflammation, as well as elimination of invading pathogens. In a recent study, Schmidt and colleagues describe the open epigenetic landscape of the human inflammatory macrophages, and the transcrip...

journal_title：Cell research

authors： Netea MG,Joosten LA

更新日期：2016-02-01 00:00:00

abstract：:Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monitor bHLH protein-protein interactions under various physiological conditions. Tissue-specific bHLH activators, ...

journal_title：Cell research

authors： Wang C,Bian W,Xia C,Zhang T,Guillemot F,Jing N

更新日期：2006-06-01 00:00:00

abstract：:The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interaction between Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showed Ese-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by a...

journal_title：Cell research

authors： Yaniw D,Hu J

更新日期：2005-06-01 00:00:00

abstract：:Accumulating evidence indicates that the mesenchymal-epithelial transition (MET) and epithelial-mesenchymal transition (EMT) are basic mechanisms for cell fate conversion and may help us understand both physiologic and pathologic processes such as development and carcinogenesis. Here, we further suggest that mammalian...

journal_title：Cell research

authors： Zheng H,Hutchins AP,Pan G,Li Y,Pei D,Pei G

更新日期：2014-10-01 00:00:00

abstract：:N6-methyladenine (N6-mA) of DNA is an emerging epigenetic mark in mammalian genome. Levels of N6-mA undergo drastic fluctuation during early embryogenesis, indicative of active regulation. Here we show that the 2-oxoglutarate-dependent oxygenase ALKBH1 functions as a nuclear eraser of N6-mA in unpairing regions (e.g.,...

journal_title：Cell research

authors： Zhang M,Yang S,Nelakanti R,Zhao W,Liu G,Li Z,Liu X,Wu T,Xiao A,Li H

更新日期：2020-03-01 00:00:00

abstract：:The tumor suppressor PTEN controls a variety of biological processes including cell proliferation, growth, migration, and death. As a master cellular regulator, PTEN itself is also subjected to deliberated regulation to ensure its proper function. Defects in PTEN regulation have a profound impact on carcinogenesis. In...

journal_title：Cell research

authors： Wang X,Jiang X

更新日期：2008-08-01 00:00:00

abstract：:The full-length cDNA of Pinellia ternata agglutinin (PTA) was cloned from inflorescences using RACE-PCR. Through comparative analysis of PTA gene (pta) and its deduced amino acid sequence with those of other Araceae species, pta was found to encode a precursor lectin with signal peptide and to have extensive homology ...

journal_title：Cell research

authors： Yao JH,Zhao XY,Liao ZH,Lin J,Chen ZH,Chen F,Song J,Sun XF,Tang KX

更新日期：2003-08-01 00:00:00

abstract：:The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this re...

journal_title：Cell research

authors： Zarubin T,Han J

更新日期：2005-01-01 00:00:00