Abstract:
:Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in the endosomes and promotes dsRNA binding and proteolytic processing of TLR3, suggesting that Mex3B acts as a coreceptor of TLR3 in response to dsRNA.
journal_name
Cell Resjournal_title
Cell researchauthors
Zhu S,Wang G,Lei X,Flavell RAdoi
10.1038/cr.2016.29subject
Has Abstractpub_date
2016-04-01 00:00:00pages
391-2issue
4eissn
1001-0602issn
1748-7838pii
cr201629journal_volume
26pub_type
评论,杂志文章相关文献
CELL RESEARCH文献大全abstract::Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through high-throughput screening, we discovered that CCDC50 functions as a previously unknown autophagy receptor that...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-020-0362-1
更新日期:2021-01-01 00:00:00
abstract::In quorum sensing (QS) process, bacteria regulate gene expression by utilizing small signaling molecules called autoinducers in response to a variety of environmental cues. Autoinducer 2 (AI-2), a QS signaling molecule proposed to be involved in interspecies communication, is produced by many species of gram-negative ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2009.91
更新日期:2009-11-01 00:00:00
abstract::Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.135
更新日期:2012-02-01 00:00:00
abstract::EKLF is an erythroid-specific, zinc finger-containing transcription factor essential for the activation of the mammalian beta globin gene in erythroid cells of definitive lineage. We have prepared a polyclonal anti-mouse EKLF antibody suitable for Western blotting and immunoprecipitation (IP) qualities, and used it to...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310045
更新日期:2006-04-01 00:00:00
abstract::Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2012.11
更新日期:2012-02-01 00:00:00
abstract::The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0092-9
更新日期:2018-11-01 00:00:00
abstract::Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive drug target. Here, we developed a split luciferase complementation-based high-throughput screening assay to id...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.88
更新日期:2017-08-01 00:00:00
abstract::Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig, namely AM67. Based on the cDNA sequence of mouse sp56, we designed a pair of primer to amplify its homologue from rat testis cDNA. Using RT-PCR, two fragments of...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290156
更新日期:2003-04-01 00:00:00
abstract::Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2008.285
更新日期:2009-03-01 00:00:00
abstract::Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2012.182
更新日期:2013-01-01 00:00:00
abstract::Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10,236,715 base pairs, is one of the largest prokaryotic genomes ever sequenced so far....
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2010.87
更新日期:2010-10-01 00:00:00
abstract::A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290182
更新日期:2003-10-01 00:00:00
abstract::Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fract...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290350
更新日期:2005-10-01 00:00:00
abstract::The 5' fragment (1 647 bp) of the cotton glucuronosyltransferase gene (GhGlcAT1) was transcriptionally fused to the beta-glucuronidase (GUS) gene, and functionally analyzed for important regulatory regions controlling gene expression in transgenic tobacco plants. GUS activity analysis revealed that the full-length pro...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310119
更新日期:2007-02-01 00:00:00
abstract::Vascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of the central nervous system. It is known that neural cells can regulate brain vascular integrity. However, due to the high complexity of neurovascular interactions involved, understanding o...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2017.62
更新日期:2017-07-01 00:00:00
abstract::Previously, mouse bone marrow-derived stem cells (MSC) treated with the unspecific DNA methyltransferase inhibitor 5-azacytidine were reported to differentiate into cardiomyocytes. The aim of the present study was to investigate the efficiency of a similar differentiation strategy in human mononuclear cells obtained f...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310116
更新日期:2006-12-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) carries out tumor suppressor activity in epithelial and lymphoid cells, whereas telomerase is required for most cancers. Although the molecular mechanisms by which TGF-beta acts as a tumor suppressor are yet to be fully established, a link between TGFb and its tumor suppresso...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/sj.cr.7310023
更新日期:2006-02-01 00:00:00
abstract::Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in m...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.74
更新日期:2011-09-01 00:00:00
abstract::Various factors/pathways including hormonal regulation have been suggested to control herpes simplex virus type 1 (HSV-1) latency and reactivation. Our computer analysis identified a DNA repeat containing thyroid hormone-responsive elements (TRE) in the regulatory region of HSV-1 latency-associated transcript (LAT). T...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2010.50
更新日期:2010-05-01 00:00:00
abstract::DNA hydrolysis is a biochemical process often associated with different forms of cell death, including apoptosis. In a recent paper published in Cell Discovery, Du et al. report that synaptic acetylcholinesterase (AChE-S) shows an unexpected enzymatic activity as DNase switched on after cytotoxic insults. ...
journal_title:Cell research
pub_type: 评论,杂志文章
doi:10.1038/cr.2015.52
更新日期:2015-06-01 00:00:00
abstract::Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellul...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290284
更新日期:2005-03-01 00:00:00
abstract::Amyloid-beta (Abeta) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated by beta-secretase- and gamma-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic protease, beta -site APP cleavage enzyme (BACE), has been identified as the main ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2007.5
更新日期:2007-05-01 00:00:00
abstract::Carotenoids, a class of natural pigments found in all photosynthetic organisms, are involved in a variety of physiological processes, including coloration, photoprotection, biosynthesis of abscisic acid (ABA) and chloroplast biogenesis. Although carotenoid biosynthesis has been well studied biochemically, the genetic ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2007.37
更新日期:2007-05-01 00:00:00
abstract::Neural stem cells (NSCs) constitute the cellular basis for embryonic brain development and neurogenesis. The process is regulated by NSC niche including neighbor cells such as vascular and glial cells. Since both vascular and glial cells secrete vascular endothelial growth factor (VEGF) and basic fibroblast growth fac...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7310126
更新日期:2007-01-01 00:00:00
abstract::While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/s41422-018-0113-8
更新日期:2019-01-01 00:00:00
abstract::The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insigh...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/sj.cr.7290208
更新日期:2004-04-01 00:00:00
abstract::Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2011.92
更新日期:2011-08-01 00:00:00
abstract::Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapper1 (Dpr1) acts as a critical regulator of the ...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/cr.2014.84
更新日期:2014-08-01 00:00:00
abstract::Transforming growth factor-beta utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions. These non-canonical, non-Smad pathways are activated directly by ligand-occupied receptors to reinforce, attenuate, or otherwise modulate downstream cellular res...
journal_title:Cell research
pub_type: 杂志文章,评审
doi:10.1038/cr.2008.328
更新日期:2009-01-01 00:00:00
abstract::There is strong relationship between melanocortin-1 receptor (MC1R) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val6...
journal_title:Cell research
pub_type: 杂志文章
doi:10.1038/sj.cr.7290070
更新日期:2001-03-01 00:00:00