Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.

abstract：:Aging is associated with many complex diseases. Reliable prediction of the aging process is important for assessing the risks of aging-associated diseases. However, despite intense research, so far there is no reliable aging marker. Here we addressed this problem by examining whether human 3D facial imaging features c...

journal_title：Cell research

authors： Chen W,Qian W,Wu G,Chen W,Xian B,Chen X,Cao Y,Green CD,Zhao F,Tang K,Han JD

更新日期：2015-05-01 00:00:00

abstract：:Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AI...

journal_title：Cell research

authors： Donjerković D,Scott DW

更新日期：2000-09-01 00:00:00

abstract：:In searching for differentially expressed genes in human uterine leiomyomas (ULs), suppression subtractive hybridization was used to construct an UL up-regulated library, which turned out to represent 88 genes. After two rounds of screening by reverse Northern analysis, twenty genes were proved to be up-regulated, inc...

journal_title：Cell research

authors： Li B,Zhang YL

更新日期：2002-09-01 00:00:00

abstract：:DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pathways is subject to regulation by multiple other factors that are not well understood. We have propos...

journal_title：Cell research

authors： Borges HL,Linden R,Wang JY

更新日期：2008-01-01 00:00:00

abstract：:Previously, mouse bone marrow-derived stem cells (MSC) treated with the unspecific DNA methyltransferase inhibitor 5-azacytidine were reported to differentiate into cardiomyocytes. The aim of the present study was to investigate the efficiency of a similar differentiation strategy in human mononuclear cells obtained f...

journal_title：Cell research

authors： Balana B,Nicoletti C,Zahanich I,Graf EM,Christ T,Boxberger S,Ravens U

更新日期：2006-12-01 00:00:00

abstract：:High-density lipoproteins (HDLs) have been well established to protect against the development of atherosclerotic cardiovascular disease. It has become apparent that in addition to the promotion of reverse cholesterol transport, HDLs possess a number of additional functional properties that may contribute to their ben...

journal_title：Cell research

authors： Cutri BA,Hime NJ,Nicholls SJ

更新日期：2006-10-01 00:00:00

abstract：:UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (...

journal_title：Cell research

authors： Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SS

更新日期：2012-06-01 00:00:00

abstract：:Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical fo...

journal_title：Cell research

authors： Geng YJ

更新日期：2001-12-01 00:00:00

abstract：:Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipula...

journal_title：Cell research

authors： Li W,Jiang K,Wei W,Shi Y,Ding S

更新日期：2013-01-01 00:00:00

abstract：:Amyloid-beta (Abeta) peptide, the primary constituent of senile plaques in Alzheimer's disease (AD), is generated by beta-secretase- and gamma-secretase-mediated sequential proteolysis of the amyloid precursor protein (APP). The aspartic protease, beta -site APP cleavage enzyme (BACE), has been identified as the main ...

journal_title：Cell research

authors： Zou L,Wang Z,Shen L,Bao GB,Wang T,Kang JH,Pei G

更新日期：2007-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions as an oncogene and has a role in tumorigenesis, in part through regulation of the tumor suppressor gene tropomyosin 1 (TPM1)...

journal_title：Cell research

authors： Zhu S,Wu H,Wu F,Nie D,Sheng S,Mo YY

更新日期：2008-03-01 00:00:00

abstract：:The Hippo pathway is a signal transduction pathway that regulates organ growth, stem cell biology, regeneration and cancer. Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel connections to cell-cell junctions, regulation by vesicle traffic...

journal_title：Cell research

authors： Moya IM,Halder G

更新日期：2014-02-01 00:00:00

abstract：:During meiotic cell division, proper chromosome synapsis and accurate repair of DNA double strand breaks (DSBs) are required to maintain genomic integrity, loss of which leads to apoptosis or meiotic defects. The mechanisms underlying meiotic chromosome synapsis, DSB repair and apoptosis are not fully understood. Here...

journal_title：Cell research

authors： Xu J,Sun X,Jing Y,Wang M,Liu K,Jian Y,Yang M,Cheng Z,Yang C

更新日期：2012-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) diss...

journal_title：Cell research

authors： Sang QX

更新日期：1998-09-01 00:00:00

abstract：:Macrophages are important innate immune cells with functions in tissue repair and remodeling, induction and resolution of inflammation, as well as elimination of invading pathogens. In a recent study, Schmidt and colleagues describe the open epigenetic landscape of the human inflammatory macrophages, and the transcrip...

journal_title：Cell research

authors： Netea MG,Joosten LA

更新日期：2016-02-01 00:00:00

abstract：:Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy, particularly autophagic degradation of cellular iron storage proteins (a process known as ferritinophagy), in ferroptosis. ...

journal_title：Cell research

authors： Gao M,Monian P,Pan Q,Zhang W,Xiang J,Jiang X

更新日期：2016-09-01 00:00:00

abstract：:KDR (kinase insert domain receptor) phosphorylation induces several effects which lead eventually to cell proliferation and survival. The precise mechanisms by which KDR, once it is activated, communicates with the nucleus are starting to be understood but have not yet been completely unravelled. Two in vitro studies ...

journal_title：Cell research

authors： Blazquez C,Cook N,Micklem K,Harris AL,Gatter KC,Pezzella F

更新日期：2006-01-01 00:00:00

abstract：:Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...

journal_title：Cell research

authors： Achilleos A,Trainor PA

更新日期：2012-02-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is highly related to mi...

journal_title：Cell research

authors： Wang J,Song X,Zhang D,Chen X,Li X,Sun Y,Li C,Song Y,Ding Y,Ren R,Harrington EH,Hu LA,Zhong W,Xu C,Huang X,Wang HW,Ma Y

更新日期：2020-05-01 00:00:00

abstract：:The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interaction between Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showed Ese-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by a...

journal_title：Cell research

authors： Yaniw D,Hu J

更新日期：2005-06-01 00:00:00

abstract：:Amycolatopsis mediterranei is used for industry-scale production of rifamycin, which plays a vital role in antimycobacterial therapy. As the first sequenced genome of the genus Amycolatopsis, the chromosome of strain U32 comprising 10,236,715 base pairs, is one of the largest prokaryotic genomes ever sequenced so far....

journal_title：Cell research

authors： Zhao W,Zhong Y,Yuan H,Wang J,Zheng H,Wang Y,Cen X,Xu F,Bai J,Han X,Lu G,Zhu Y,Shao Z,Yan H,Li C,Peng N,Zhang Z,Zhang Y,Lin W,Fan Y,Qin Z,Hu Y,Zhu B,Wang S,Ding X,Zhao GP

更新日期：2010-10-01 00:00:00

abstract：:NF-κBs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-κB activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the N...

journal_title：Cell research

authors： Zheng C,Yin Q,Wu H

更新日期：2011-01-01 00:00:00

abstract：:Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane-associated E3 ubiquitin ligase and its RING finger domain is required for the ubiquitin ligase activity. Immu...

journal_title：Cell research

authors： Zhang Q,Meng Y,Zhang L,Chen J,Zhu D

更新日期：2009-03-01 00:00:00

abstract：:The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the un...

journal_title：Cell research

authors： Lv X,Han Z,Chen H,Yang B,Yang X,Xia Y,Pan C,Fu L,Zhang S,Han H,Wu M,Zhou Z,Zhang L,Li L,Wei G,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:Toll-Like Receptors (TLRs) play critical roles in the early innate immune response to invading pathogens by sensing microorganisms; a number of accessory molecules have been shown to assist microbial recognition by TLRs. In a recent paper in Cell Research, Yang et al. demonstrate that Mex3B is associated with TLR3 in ...

journal_title：Cell research

authors： Zhu S,Wang G,Lei X,Flavell RA

更新日期：2016-04-01 00:00:00

abstract：:Human cytosolic NADP-IDH (IDH1) has recently been found to be involved in tumorigenesis. Notably, the tumor-derived IDH1 mutations identified so far mainly occur at Arg132, and mutation R132H is the most prevalent one. This mutation impairs the oxidative IDH activity of the enzyme, but renders a new reduction function...

journal_title：Cell research

authors： Yang B,Zhong C,Peng Y,Lai Z,Ding J

更新日期：2010-11-01 00:00:00

abstract：:The partitioning-defective 3 (Par3), a key component in the conserved Par3/Par6/aPKC complex, plays fundamental roles in cell polarity. Herein we report the identification of Ku70 and Ku80 as novel Par3-interacting proteins through an in vitro binding assay followed by liquid chromatography-tandem mass spectrometry. K...

journal_title：Cell research

authors： Fang L,Wang Y,Du D,Yang G,Tak Kwok T,Kai Kong S,Chen B,Chen DJ,Chen Z

更新日期：2007-02-01 00:00:00

abstract：:There is strong relationship between melanocortin-1 receptor (MC1R) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val6...

journal_title：Cell research

authors： Peng S,Lu XM,Luo HR,Xiang-Yu JG,Zhang YP

更新日期：2001-03-01 00:00:00

abstract：:Type I interferon (IFN) production plays pivotal roles in host antiviral innate immune responses, but an excessive production of type I IFN leads to the development of immunopathological conditions. Investigations on the regulatory mechanisms underlying host type I IFN production are currently of great interest. Here,...

journal_title：Cell research

authors： Zheng Q,Hou J,Zhou Y,Yang Y,Xie B,Cao X

更新日期：2015-10-01 00:00:00