Cloning of rat sp56, the homologue of mouse sperm ZP3 receptor-sp56.

abstract：:Bone-marrow-derived mesenchymal stem cells (MSCs) have been shown to possess immunosuppressive properties, e.g., by inhibiting T cell proliferation. Activated T cells can also enhance the immunosuppression ability of MSCs. The precise mechanisms underlying MSC-mediated immunosuppression remain largely undefined, altho...

journal_title：Cell research

authors： Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N

更新日期：2008-08-01 00:00:00

abstract：:T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity in autoimmune neuroinflammation but not in experimental colitis. Although STAT5 promotes regulatory T cell generation and imm...

journal_title：Cell research

authors： Sheng W,Yang F,Zhou Y,Yang H,Low PY,Kemeny DM,Tan P,Moh A,Kaplan MH,Zhang Y,Fu XY

更新日期：2014-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell research

authors： Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

更新日期：2020-06-01 00:00:00

abstract：:Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial d...

journal_title：Cell research

authors： Gan Z,Fu T,Kelly DP,Vega RB

更新日期：2018-10-01 00:00:00

abstract：:In order to analyze the mechanism of immuno-modulation by LPS on murine peritoneal suppressor macrophages, we have, using RNase protection assay, checked the changes of mRNA expression pattern of several cytokine genes during the immuno-modulation. It has been found that, after treating peritoneal suppressor macrophag...

journal_title：Cell research

authors： Feng WG,Chang ZL

更新日期：1998-12-01 00:00:00

abstract：:Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fiber of kinetochore. Using immunoelectron microscopy, here we show that TTK is present at the nuclear pore adjace...

journal_title：Cell research

authors： Dou Z,Sawagechi A,Zhang J,Luo H,Brako L,Yao XB

更新日期：2003-12-01 00:00:00

abstract：:The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms involved in chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind to mammali...

journal_title：Cell research

authors： Simonet T,Zaragosi LE,Philippe C,Lebrigand K,Schouteden C,Augereau A,Bauwens S,Ye J,Santagostino M,Giulotto E,Magdinier F,Horard B,Barbry P,Waldmann R,Gilson E

更新日期：2011-07-01 00:00:00

abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder often considered to be the third most common muscular dystrophy. Deletions reducing the copy number of the D4Z4 repeat in the distal end of the 4q arm are the main genetic cause of the disease. The recently highlighted research has identified a ...

journal_title：Cell research

authors： Vizoso M,Esteller M

更新日期：2012-10-01 00:00:00

abstract：:Over the past four years, the field of the innate immune response has been highly influenced by the discovery of the IkappaB kinase (IKK)-related kinases, TANK Binding Kinase 1 (TBK1) and IKKi, which regulate the activity of interferon regulatory factor (IRF)-3/IRF-7 and NF-kappaB transcription factors. More recently,...

journal_title：Cell research

authors： Clément JF,Meloche S,Servant MJ

更新日期：2008-09-01 00:00:00

abstract：:UV-B (280-315 nm) is an integral part of solar radiation and can act either as a stress inducer or as a developmental signal. In recent years, increasing attention has been paid to the low-fluence UV-B-induced photomorphogenic response and several key players in this response have been identified, which include UVR8 (...

journal_title：Cell research

authors： Jiang L,Wang Y,Li QF,Björn LO,He JX,Li SS

更新日期：2012-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) diss...

journal_title：Cell research

authors： Sang QX

更新日期：1998-09-01 00:00:00

abstract：:Phosphatidylinositol 3-phosphate (PI3P) plays essential roles in vesicular trafficking, organelle biogenesis and autophagy. Two class III phosphatidylinositol 3-kinase (PI3KC3) complexes have been identified in mammals, the ATG14L complex (PI3KC3-C1) and the UVRAG complex (PI3KC3-C2). PI3KC3-C1 is crucial for autophag...

journal_title：Cell research

authors： Ma M,Liu JJ,Li Y,Huang Y,Ta N,Chen Y,Fu H,Ye MD,Ding Y,Huang W,Wang J,Dong MQ,Yu L,Wang HW

更新日期：2017-08-01 00:00:00

abstract：:The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...

journal_title：Cell research

authors： Zhang Z,Wang M,Xie D,Huang Z,Zhang L,Yang Y,Ma D,Li W,Zhou Q,Yang YG,Wang XJ

更新日期：2018-11-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC) comprises various molecular subgroups with unclear identities and currently has few targeted treatment options. Our previous study identified protein C receptor (Procr) as a surface marker on mammary stem cells (MaSCs) locate...

journal_title：Cell research

authors： Wang D,Hu X,Liu C,Jia Y,Bai Y,Cai C,Wang J,Bai L,Yang R,Lin C,Liu YR,Li S,Qiao F,Yao L,Chen L,Ge G,Jiang H,Li D,Li L,Chen J,Shao ZM,Zeng YA

更新日期：2019-10-01 00:00:00

abstract：:CRISPR-Cas9 and CRISPR-Cpf1 systems have been successfully harnessed for genome editing. In the CRISPR-Cas9 system, the preordered A-form RNA seed sequence and preformed protein PAM-interacting cleft are essential for Cas9 to form a DNA recognition-competent structure. Whether the CRISPR-Cpf1 system employs a similar ...

journal_title：Cell research

authors： Gao P,Yang H,Rajashankar KR,Huang Z,Patel DJ

更新日期：2016-08-01 00:00:00

abstract：:Using two-colour flow cytometry >200 antibodies submitted to the 8th International Workshop of Human Leukocyte Differentiation Antigens (HLDA8) have been analyzed for their reactivity with resting and activated CD203c+ basophils. Four antibodies either non-reactive or weakly reactive with resting basophils exhibited a...

journal_title：Cell research

authors： Hennersdorf F,Florian S,Jakob A,Baumgärtner K,Sonneck K,Nordheim A,Biedermann T,Valent P,Bühring HJ

更新日期：2005-05-01 00:00:00

abstract：:DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site thr...

journal_title：Cell research

authors： Lai F,Shiekhattar R

更新日期：2014-03-01 00:00:00

abstract：:The aneuploid with isochromosome or telochromosome is ideal material for exploring the position of centromere in lingkage map. For obtaining these aneuploids in rice, the primary trisomics from triplo-1 to triplo-12 and the aneuploids derived from a triploid of indica rice variety Zhongxian 3037 were carefully investi...

journal_title：Cell research

authors： Cheng ZK,Yu HX,Yan CJ,Zhu LH,Gu MH

更新日期：1997-06-01 00:00:00

abstract：:Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing a...

journal_title：Cell research

authors： Fan XQ,Guo YJ

更新日期：2001-03-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:The Wnt/β-catenin pathway plays important roles in the differentiation of multiple cell types, including mesenchymal stem cells. Using a cell-based chemical screening assay with a synthetic chemical library of 270 000 compounds, we identified the compound SKL2001 as a novel agonist of the Wnt/β-catenin pathway and unc...

journal_title：Cell research

authors： Gwak J,Hwang SG,Park HS,Choi SR,Park SH,Kim H,Ha NC,Bae SJ,Han JK,Kim DE,Cho JW,Oh S

更新日期：2012-01-01 00:00:00

abstract：:Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase...

journal_title：Cell research

authors： Li BZ,Huang Z,Cui QY,Song XH,Du L,Jeltsch A,Chen P,Li G,Li E,Xu GL

更新日期：2011-08-01 00:00:00

abstract：:Human polymorphonuclear leukocytes (PMN) have been reported to completely lack of DNA-dependent protein kinase (DNA-PK) which is composed of Ku protein and the catalytic subunit DNA-PKcs, needed for nonhomologous end-joining (NHEJ) of DNA double-strand breaks. Promyelocytic HL-60 cells express a variant form of Ku res...

journal_title：Cell research

authors： Sallmyr A,Miller A,Gabdoulkhakova A,Safronova V,Henriksson G,Bredberg A

更新日期：2004-08-01 00:00:00

abstract：:While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation...

journal_title：Cell research

authors： Covarrubias A,Byles V,Horng T

更新日期：2013-08-01 00:00:00

abstract：:CCAAT/enhancer binding protein alpha (C/EBPalpha) is a transcriptional regulatory factor that inhibits cell proliferation, and alternative translational initiation produces two polypeptides, C/EBPalphap30 and C/EBPalphap42. By expression profiling, it was revealed that C/EBPalphap30 specifically inhibited a unique set...

journal_title：Cell research

authors： Wang C,Chen X,Wang Y,Gong J,Hu G

更新日期：2007-04-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a core component of raptor-mTOR (mTORC1) and rictor-mTOR (mTORC2) complexes that control diverse cellular processes. Both mTORC1 and mTORC2 regulate several elements downstream of type I insulin-like growth factor receptor (IGF-IR) and insulin receptor (InsR). However, it is unk...

journal_title：Cell research

authors： Yin Y,Hua H,Li M,Liu S,Kong Q,Shao T,Wang J,Luo Y,Wang Q,Luo T,Jiang Y

更新日期：2016-01-01 00:00:00

abstract：:The rice Eui (ELONGATED UPPERMOST INTERNODE) gene encodes a cytochrome P450 monooxygenase that deactivates bioactive gibberellins (GAs). In this study, we investigated controlled expression of the Eui gene and its role in plant development. We found that Eui was differentially induced by exogenous GAs and that the Eui...

journal_title：Cell research

authors： Zhang Y,Zhu Y,Peng Y,Yan D,Li Q,Wang J,Wang L,He Z

更新日期：2008-03-01 00:00:00

abstract：:Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking. As sorting nexin (SNX) molecules are essential components of the retromer complex, we hypot...

journal_title：Cell research

authors： Zhang P,Wu Y,Belenkaya TY,Lin X

更新日期：2011-12-01 00:00:00

abstract：:Immunization with inactivated autoreactive T cells is an effective therapeutic approach to ameliorating autoimmune diseases, while the underlying mechanisms that regulate autoreactive T cells are not completely understood. This study tested the hypothesis that T-cell vaccination (TCV) inhibits autoimmune diabetes in m...

journal_title：Cell research

authors： Wang M,Yang L,Sheng X,Chen W,Tang H,Sheng H,Xi B,Zang YQ

更新日期：2011-09-01 00:00:00

abstract：:Mammalian cell totipotency is a subject that has fascinated scientists for generations. A long lasting question whether some of the somatic cells retains totipotency was answered by the cloning of Dolly at the end of the 20th century. The dawn of the 21st has brought forward great expectations in harnessing the power ...

journal_title：Cell research

authors： Pan GJ,Chang ZY,Schöler HR,Pei D

更新日期：2002-12-01 00:00:00