Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.

abstract：:Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex formation is regulated is unclear. Here, we show that Dapper1 (Dpr1) acts as a critical regulator of the ...

journal_title：Cell research

authors： Ma B,Cao W,Li W,Gao C,Qi Z,Zhao Y,Du J,Xue H,Peng J,Wen J,Chen H,Ning Y,Huang L,Zhang H,Gao X,Yu L,Chen YG

更新日期：2014-08-01 00:00:00

abstract：:Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk between tumor and stromal cells. However, how PGE2-mediated signaling modulates t...

journal_title：Cell research

authors： Li P,Shan JX,Chen XH,Zhang D,Su LP,Huang XY,Yu BQ,Zhi QM,Li CL,Wang YQ,Tomei S,Cai Q,Ji J,Li JF,Chouchane L,Yu YY,Sun FZ,Xu ZH,Liu BY,Zhu ZG

更新日期：2015-05-01 00:00:00

abstract：:A recent paper published in Nature reports sensory nerve fibers in the skin that give local immune cells important instructions for the organization of an immune response; in this particular case the cooperation between the nervous and immune systems had disastrous consequences, namely an auto-destruction of the skin....

journal_title：Cell research

authors： Odoardi F,Neuhuber W,Flügel A

更新日期：2014-09-01 00:00:00

abstract：:circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic...

journal_title：Cell research

authors： Guarnerio J,Zhang Y,Cheloni G,Panella R,Mae Katon J,Simpson M,Matsumoto A,Papa A,Loretelli C,Petri A,Kauppinen S,Garbutt C,Nielsen GP,Deshpande V,Castillo-Martin M,Cordon-Cardo C,Dimitrios S,Clohessy JG,Batish M,Pan

更新日期：2019-08-01 00:00:00

abstract：:Naïve CD4 T cells can differentiate into at least two different types of T helpers, Th1 and Th2 cells. Th2 cells, capable of producing IL-4, IL-5 and IL-13, are involved in humoral immunity against extracellular pathogens and in the induction of asthma and other allergic diseases. In this review, we summarize recent r...

journal_title：Cell research

authors： Zhu J,Yamane H,Cote-Sierra J,Guo L,Paul WE

更新日期：2006-01-01 00:00:00

abstract：:Our previous study has demonstrated that CD146 molecule is a biomarker on vascular endothelium, which is involved in angiogenesis and tumor growth. However the mechanism behind is not clear. Here we have for the first time developed a novel CD146 blockade system using CD146 siRNA to study its function on endothelial c...

journal_title：Cell research

authors： Kang Y,Wang F,Feng J,Yang D,Yang X,Yan X

更新日期：2006-03-01 00:00:00

abstract：:In searching for differentially expressed genes in human uterine leiomyomas (ULs), suppression subtractive hybridization was used to construct an UL up-regulated library, which turned out to represent 88 genes. After two rounds of screening by reverse Northern analysis, twenty genes were proved to be up-regulated, inc...

journal_title：Cell research

authors： Li B,Zhang YL

更新日期：2002-09-01 00:00:00

abstract：:In mice treated with antibiotics to deplete commensal microbiota, there is a significant overhaul of host cellular disposition and function with CX3CR1+ mononuclear phagocytic cells carrying pathogenic and non-pathogenic administered bacteria to the (messenteric lymph node) MLN, resulting in T cell stimulation and IgA...

journal_title：Cell research

authors： Dasgupta S,Kasper DL

更新日期：2013-05-01 00:00:00

abstract：:The neurodegenerative polyglutamine diseases are caused by an expansion of unstable polyglutamine repeats in various disease proteins. Although these mutant proteins are expressed ubiquitously in neuronal and non-neuronal cells, they cause selective degeneration of specific neuronal populations. Recently, increasing e...

journal_title：Cell research

authors： Bradford JW,Li S,Li XJ

更新日期：2010-04-01 00:00:00

abstract：:The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin...

journal_title：Cell research

authors： Han JD

更新日期：2008-02-01 00:00:00

abstract：:Gonad development requires a coordinated soma-germline interaction that ensures renewal and differentiation of germline and somatic stem cells to ultimately produce mature gametes. The Drosophila tumour suppressor gene discs large (dlg) encodes a septate junction protein functioning during epithelial polarization, asy...

journal_title：Cell research

authors： Papagiannouli F,Mechler BM

更新日期：2009-10-01 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a core component of raptor-mTOR (mTORC1) and rictor-mTOR (mTORC2) complexes that control diverse cellular processes. Both mTORC1 and mTORC2 regulate several elements downstream of type I insulin-like growth factor receptor (IGF-IR) and insulin receptor (InsR). However, it is unk...

journal_title：Cell research

authors： Yin Y,Hua H,Li M,Liu S,Kong Q,Shao T,Wang J,Luo Y,Wang Q,Luo T,Jiang Y

更新日期：2016-01-01 00:00:00

abstract：:The formation of long-term memory is critical for learning ability and social behaviors of humans and animals, yet its underlying mechanisms are largely unknown. We found that the efficacy of hippocampus-dependent memory consolidation is regulated by METTL3, an RNA N6-methyladenosine (m6A) methyltransferase, through p...

journal_title：Cell research

authors： Zhang Z,Wang M,Xie D,Huang Z,Zhang L,Yang Y,Ma D,Li W,Zhou Q,Yang YG,Wang XJ

更新日期：2018-11-01 00:00:00

abstract：:Brassinosteroids (BRs) are essential steroid hormones that have crucial roles in plant growth and development. BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1). In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl te...

journal_title：Cell research

authors： Wang J,Jiang J,Wang J,Chen L,Fan SL,Wu JW,Wang X,Wang ZX

更新日期：2014-11-01 00:00:00

abstract：:Wnt/β-catenin signaling is essential for the initiation of dorsal-ventral patterning during vertebrate embryogenesis. Maternal β-catenin accumulates in dorsal marginal nuclei during cleavage stages, but its critical target genes essential for dorsalization are silent until mid-blastula transition (MBT). Here, we find ...

journal_title：Cell research

authors： Wei S,Dai M,Liu Z,Ma Y,Shang H,Cao Y,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:Spontaneous Ca2+ oscillations in vascular smooth muscle cells have been modeled using a single Ca2+ pool. This report describes spontaneous Ca2+ oscillations dependent on two separate Ca2+ sources for the nuclear versus cytoplasmic compartments. Changes in free intracellular Ca2+ were monitored with ratiometric Ca2+- ...

journal_title：Cell research

authors： Fedoryak OD,Searls Y,Smirnova IV,Burns DM,Stehno-Bittel L

更新日期：2004-10-01 00:00:00

abstract：:Calcium-dependent proteolytic calpains are implicated in a variety of physiological processes, as well as pathologies associated with calcium overload. However, the mechanism by which calpain is activated remains elusive since intracellular calcium levels under physiological conditions do not reach the high concentrat...

journal_title：Cell research

authors： Metwally E,Zhao G,Wang Q,Zhang YQ

更新日期：2020-08-26 00:00:00

abstract：:Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic ...

journal_title：Cell research

authors： Pan T

更新日期：2018-04-01 00:00:00

abstract：:MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabditis elegans. In this paper, we show that a mutant Arabidopsis plant carrying the putative disrupted AtMSH5...

journal_title：Cell research

authors： Lu X,Liu X,An L,Zhang W,Sun J,Pei H,Meng H,Fan Y,Zhang C

更新日期：2008-05-01 00:00:00

abstract：:Craniofacial anomalies (CFAs) characterized by birth defects of skull and facial bones are the most frequent congenital disease. Genomic analysis has identified multiple genes responsible for CFAs; however, the underlying genetic mechanisms for the majority of CFAs remain largely unclear. Our previous study revealed t...

journal_title：Cell research

authors： Shao R,Liu J,Yan G,Zhang J,Han Y,Guo J,Xu Z,Yuan Z,Liu J,Malumbres M,Wan L,Wei W,Zou W

更新日期：2016-06-01 00:00:00

abstract：:Neural crest (NC) cells are a migratory cell population synonymous with vertebrate evolution. They generate a wide variety of cell and tissue types during embryonic and adult development including cartilage and bone, connective tissue, pigment and endocrine cells as well as neurons and glia amongst many others. Such i...

journal_title：Cell research

authors： Achilleos A,Trainor PA

更新日期：2012-02-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) participate in the processes of postnatal neovascularization and re-endothelialization in response to tissue ischemia and endothelial injury. The level of EPCs present has been found to be directly associated with the outcome of cardiovascular diseases, and could be regulated by sti...

journal_title：Cell research

authors： Yin T,Ma X,Zhao L,Cheng K,Wang H

更新日期：2008-07-01 00:00:00

abstract：:Interleukin (IL)-8 is a potent neutrophil chemotactic factor and a crucial mediator in neutrophil-dependent inflammation. Various cell types produce IL-8, either in response to external stimuli such as cytokines or bacterial infection, or after malignant transformation. Anti-IL-8 strategies have been considered for an...

journal_title：Cell research

authors： Cao HB,Wang A,Martin B,Koehler DR,Zeitlin PL,Tanawell AK,Hu J

更新日期：2005-02-01 00:00:00

abstract：:Pluripotent stem cells (PSCs) harbor constitutive DNA replication stress during their rapid proliferation and the consequent genome instability hampers their applications in regenerative medicine. It is therefore important to understand the regulatory mechanisms of replication stress response in PSCs. Here, we report ...

journal_title：Cell research

authors： Zhao B,Zhang W,Cun Y,Li J,Liu Y,Gao J,Zhu H,Zhou H,Zhang R,Zheng P

更新日期：2018-01-01 00:00:00

abstract：:Why stem cell numbers decline with age is a major question in regenerative biology and medicine. Skeletal muscle has emerged as a powerful paradigm to address this issue. Recently, genetic and cell marking strategies were used to uncover a new and causal relationship between muscle stem cells and differentiated fibers...

journal_title：Cell research

authors： Tajbakhsh S

更新日期：2013-04-01 00:00:00

abstract：:Human gastric cancer MKN-45 cells were transfected with pULB 3238, a plasmid carrying MVMp NS-1 gene with its original P4 promoter replaced by the glucocorticoid inducible promoter MMTV-LTR. After the integration and expression of NS-1 gene, some of the transfectants died, while others remained alive, but the growth f...

journal_title：Cell research

authors： Shen XZ,Tsung HC,Yang YW,Yang QH,Xiao SD

更新日期：1997-12-01 00:00:00

abstract：:While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2 ...

journal_title：Cell research

authors： Wu R,Li A,Sun B,Sun JG,Zhang J,Zhang T,Chen Y,Xiao Y,Gao Y,Zhang Q,Ma J,Yang X,Liao Y,Lai WY,Qi X,Wang S,Shu Y,Wang HL,Wang F,Yang YG,Yuan Z

更新日期：2019-01-01 00:00:00

abstract：:The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can be achieved in the heart in situ, and suggest a novel, regenerative ...

journal_title：Cell research

authors： Xu H,Yi BA,Chien KR

更新日期：2012-11-01 00:00:00

abstract：:Kinesins are microtubule-based motors involved in various intracellular transports. Neurons, flagellated cells, and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins. Here, we report silkworm posterior silkgland (PSG), specialized cells with an extensive endomembra...

journal_title：Cell research

authors： Wang Q,Teng J,Shen B,Zhang W,Guo Y,Su X,Zhang C,Yu AC,Chen J

更新日期：2010-06-01 00:00:00

abstract：:Interactions are the essence of all biomolecules because they cannot fulfill their roles without interacting with other molecules. Hence, mapping the interactions of biomolecules can be useful for understanding their roles and functions. Furthermore, the development of molecular based systems biology requires an under...

journal_title：Cell research

authors： Figeys D

更新日期：2008-07-01 00:00:00